DegronMD

Uniprot ID: Q99607

Source protein: ETS-related transcription factor Elf-4

Source gene: ELF4

Class: DEG_SCF_FBW7_2

Location: 607:614

E3 ligase: FBXW7

DEGRON score: 0.7704

ASA_SCORE: 67.7125

COIL: 0.6658

CONS_SCORE: 0.3034

DSS_SCORE: 0.5465

HELIX: 0.0744

FCONS_SCORE: 1.163

RIG_SCORE: 0.7422

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G620C	TCGA-44-8117	LUAD	TCGA	VGLTPVAE	DEG_SCF_FBW7_2	0.1667
p.G620C	DO24028	LUAD	ICGC	VGLTPVAE	DEG_SCF_FBW7_2	0.1667
p.S623Y	TCGA-DD-A3A3	LIHC	TCGA	VGLTPVAE	DEG_SCF_FBW7_2	0.0833
p.S623Y	DO44878	LIHC	ICGC	VGLTPVAE	DEG_SCF_FBW7_2	0.0833
p.P601T	DO229018	LICA	ICGC	VGLTPVAE	DEG_SCF_FBW7_2	0.1667
p.L615I	DO229032	LICA	ICGC	VGLTPVAE	DEG_SCF_FBW7_2	0.3056
p.L617F	SIDM00683	Prostate Carcinoma	GDSC	VGLTPVAE	DEG_SCF_FBW7_2	0.25
p.L617F	ACH-000977	lymph_node	CCLE	VGLTPVAE	DEG_SCF_FBW7_2	0.25
p.L617F	LNCaP-Clone-FGC	prostate	COSMIC	VGLTPVAE	DEG_SCF_FBW7_2	0.25
p.L616F	LNCaP-Clone-FGC	prostate	COSMIC	VGLTPVAE	DEG_SCF_FBW7_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99607	ETS-related transcription factor Elf-4	DEG_SCF_FBW7_2	607:614	VGLTPVAE	FBXW7	0.7704	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons