DegronMD

Uniprot ID: Q5THR3

Source protein: EF-hand calcium-binding domain-containing protein 6

Source gene: EFCAB6

Class: DEG_SCF_FBW7_1

Location: 1292:1298

E3 ligase: FBXW7

DEGRON score: 0.9748

ASA_SCORE: 75.5286

COIL: 0.9194

CONS_SCORE: 0.2977

DSS_SCORE: 0.6638

HELIX: 0.025

FCONS_SCORE: 0.962

RIG_SCORE: 0.6066

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1306L	TCGA-32-2632	GBM	TCGA	PCTPAST	DEG_SCF_FBW7_1	0.1111
p.A1296S	TCGA-A5-A0G2	UCEC	TCGA	PCTPAST	DEG_SCF_FBW7_1	0.6477
p.Q1289H	TCGA-EE-A20F	SKCM	TCGA	PCTPAST	DEG_SCF_FBW7_1	0.25
p.S1288L	TCGA-EY-A1GI	UCEC	TCGA	PCTPAST	DEG_SCF_FBW7_1	0.2222
p.S1288L	SIDM00469	Pancreatic Carcinoma	GDSC	PCTPAST	DEG_SCF_FBW7_1	0.2222
p.S1288L	ACH-000320	Pancreatic Cancer	CCLE	PCTPAST	DEG_SCF_FBW7_1	0.2222
p.S1288L	ACH-002066	Sarcoma	CCLE	PCTPAST	DEG_SCF_FBW7_1	0.2222
p.S1288L	PSN1	pancreas	COSMIC	PCTPAST	DEG_SCF_FBW7_1	0.2222
p.P1292L	TCGA-FW-A3R5	SKCM	TCGA	PCTPAST	DEG_SCF_FBW7_1	0.6471
p.R1288Q	DO51214	BRCA	ICGC	PCTPAST	DEG_SCF_FBW7_1	0.2222
p.R1288Q	DO222427	BTCA	ICGC	PCTPAST	DEG_SCF_FBW7_1	0.2222
p.R1289C	DO8842	COAD	ICGC	PCTPAST	DEG_SCF_FBW7_1	0.25
p.V1304I	DO9964	COAD	ICGC	PCTPAST	DEG_SCF_FBW7_1	0.1667
p.V1304I	DO9530	COAD	ICGC	PCTPAST	DEG_SCF_FBW7_1	0.1667
p.Y1294C	DO52438	COCA	ICGC	PCTPAST	DEG_SCF_FBW7_1	0.7087
p.S1293R	DO229041	LICA	ICGC	PCTPAST	DEG_SCF_FBW7_1	0.7427
p.R1289S	DO26553	LUSC	ICGC	PCTPAST	DEG_SCF_FBW7_1	0.25
p.D1306N	DO37881	SKCM	ICGC	PCTPAST	DEG_SCF_FBW7_1	0.1111
p.R1289H	DO47469	SKCM	ICGC	PCTPAST	DEG_SCF_FBW7_1	0.25
p.R1289H	DO38551	STAD	ICGC	PCTPAST	DEG_SCF_FBW7_1	0.25
p.R1289H	DB	haematopoietic_and_lymphoid_tissue	COSMIC	PCTPAST	DEG_SCF_FBW7_1	0.25
p.H1282R	DO41536	UCEC	ICGC	PCTPAST	DEG_SCF_FBW7_1	0.0556
p.A1305T	DO41235	UCEC	ICGC	PCTPAST	DEG_SCF_FBW7_1	0.1389
p.A1296V	SIDM01617	Endometrial Carcinoma	GDSC	PCTPAST	DEG_SCF_FBW7_1	0.5825
p.A1296V	ACH-000994	Endometrial/Uterine Cancer	CCLE	PCTPAST	DEG_SCF_FBW7_1	0.5825
p.P1284L	ACH-001408	Bladder Cancer	CCLE	PCTPAST	DEG_SCF_FBW7_1	0.1111
p.R1288W	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	PCTPAST	DEG_SCF_FBW7_1	0.2222
p.R1288W	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	PCTPAST	DEG_SCF_FBW7_1	0.2222
p.R1285K	COLO-792	skin	COSMIC	PCTPAST	DEG_SCF_FBW7_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PCTPAST

Degron related mutations and impact score

Drug responses associated with EFCAB6 mutations

All proteins holding degron of PCTPAST

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5THR3	EF-hand calcium-binding domain-containing protein 6	DEG_SCF_FBW7_1	1292:1298	PCTPAST	FBXW7	0.9748	More...