DegronMD

Uniprot ID: Q5THR3

Source protein: EF-hand calcium-binding domain-containing protein 6

Source gene: EFCAB6

Class: DEG_SCF_FBW7_1

Location: 1292:1298

E3 ligase: FBXW7

DEGRON score: 0.9748

ASA_SCORE: 75.5286

COIL: 0.9194

CONS_SCORE: 0.2977

DSS_SCORE: 0.6638

HELIX: 0.025

FCONS_SCORE: 0.962

RIG_SCORE: 0.6066

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1293R	DO229041	LICA	ICGC	PCTPAST	DEG_SCF_FBW7_1	0.7427
p.Y1294C	DO52438	COCA	ICGC	PCTPAST	DEG_SCF_FBW7_1	0.7087
p.A1296S	TCGA-A5-A0G2	UCEC	TCGA	PCTPAST	DEG_SCF_FBW7_1	0.6477
p.P1292L	TCGA-FW-A3R5	SKCM	TCGA	PCTPAST	DEG_SCF_FBW7_1	0.6471
p.A1296V	SIDM01617	Endometrial Carcinoma	GDSC	PCTPAST	DEG_SCF_FBW7_1	0.5825
p.A1296V	ACH-000994	Endometrial/Uterine Cancer	CCLE	PCTPAST	DEG_SCF_FBW7_1	0.5825
p.Q1289H	TCGA-EE-A20F	SKCM	TCGA	PCTPAST	DEG_SCF_FBW7_1	0.25
p.R1289C	DO8842	COAD	ICGC	PCTPAST	DEG_SCF_FBW7_1	0.25
p.R1289S	DO26553	LUSC	ICGC	PCTPAST	DEG_SCF_FBW7_1	0.25
p.R1289H	DO47469	SKCM	ICGC	PCTPAST	DEG_SCF_FBW7_1	0.25
p.R1289H	DO38551	STAD	ICGC	PCTPAST	DEG_SCF_FBW7_1	0.25
p.R1289H	DB	haematopoietic_and_lymphoid_tissue	COSMIC	PCTPAST	DEG_SCF_FBW7_1	0.25
p.S1288L	TCGA-EY-A1GI	UCEC	TCGA	PCTPAST	DEG_SCF_FBW7_1	0.2222
p.S1288L	SIDM00469	Pancreatic Carcinoma	GDSC	PCTPAST	DEG_SCF_FBW7_1	0.2222
p.S1288L	ACH-000320	Pancreatic Cancer	CCLE	PCTPAST	DEG_SCF_FBW7_1	0.2222
p.S1288L	ACH-002066	Sarcoma	CCLE	PCTPAST	DEG_SCF_FBW7_1	0.2222
p.S1288L	PSN1	pancreas	COSMIC	PCTPAST	DEG_SCF_FBW7_1	0.2222
p.R1288Q	DO51214	BRCA	ICGC	PCTPAST	DEG_SCF_FBW7_1	0.2222
p.R1288Q	DO222427	BTCA	ICGC	PCTPAST	DEG_SCF_FBW7_1	0.2222
p.R1288W	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	PCTPAST	DEG_SCF_FBW7_1	0.2222
p.R1288W	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	PCTPAST	DEG_SCF_FBW7_1	0.2222
p.V1304I	DO9964	COAD	ICGC	PCTPAST	DEG_SCF_FBW7_1	0.1667
p.V1304I	DO9530	COAD	ICGC	PCTPAST	DEG_SCF_FBW7_1	0.1667
p.A1305T	DO41235	UCEC	ICGC	PCTPAST	DEG_SCF_FBW7_1	0.1389
p.R1285K	COLO-792	skin	COSMIC	PCTPAST	DEG_SCF_FBW7_1	0.1389

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Drug responses associated with EFCAB6 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PCTPAST

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5THR3	EF-hand calcium-binding domain-containing protein 6	DEG_SCF_FBW7_1	1292:1298	PCTPAST	FBXW7	0.9748	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PCTPAST

Degron related mutations and impact score

Drug responses associated with EFCAB6 mutations

All proteins holding degron of PCTPAST