DegronMD

Uniprot ID: Q5THR3

Source protein: EF-hand calcium-binding domain-containing protein 6

Source gene: EFCAB6

Class: DEG_SCF_FBW7_1

Location: 713:719

E3 ligase: FBXW7

DEGRON score: 0.6473

ASA_SCORE: 86.2429

COIL: 0.91

CONS_SCORE: 0.3191

DSS_SCORE: 0.6716

HELIX: 0.0571

FCONS_SCORE: 0.8861

RIG_SCORE: 0.5856

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S719C	TCGA-85-7699	LUSC	TCGA	PPTPSKS	DEG_SCF_FBW7_1	0.7541
p.P706S	TCGA-A5-A0G1	UCEC	TCGA	PPTPSKS	DEG_SCF_FBW7_1	0.1389
p.A728T	TCGA-A5-A0G2	UCEC	TCGA	PPTPSKS	DEG_SCF_FBW7_1	0.0833
p.S723I	TCGA-EK-A2PI	CESC	TCGA	PPTPSKS	DEG_SCF_FBW7_1	0.2222
p.V721M	TCGA-G4-6309	COAD	TCGA	PPTPSKS	DEG_SCF_FBW7_1	0.2778
p.D728H	DO51863	BLCA	ICGC	PPTPSKS	DEG_SCF_FBW7_1	0.0833
p.E706G	DO14403	HNSC	ICGC	PPTPSKS	DEG_SCF_FBW7_1	0.1389
p.R717C	DO45382	LUAD	ICGC	PPTPSKS	DEG_SCF_FBW7_1	0.8301
p.G711S	DO218872	SKCA	ICGC	PPTPSKS	DEG_SCF_FBW7_1	0.2778
p.R718Q	DO50299	SKCM	ICGC	PPTPSKS	DEG_SCF_FBW7_1	0.7329
p.G726D	DO51254	SKCM	ICGC	PPTPSKS	DEG_SCF_FBW7_1	0.1389
p.D728G	DO42568	UCEC	ICGC	PPTPSKS	DEG_SCF_FBW7_1	0.0833
p.D728G	Mo-T	haematopoietic_and_lymphoid_tissue	COSMIC	PPTPSKS	DEG_SCF_FBW7_1	0.0833
p.D728E	SNU-1040	large_intestine	COSMIC	PPTPSKS	DEG_SCF_FBW7_1	0.0833
p.I720M	NCI-H1836	lung	COSMIC	PPTPSKS	DEG_SCF_FBW7_1	0.3056
p.G713D	EW-1	bone	COSMIC	PPTPSKS	DEG_SCF_FBW7_1	0.7198

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5THR3	EF-hand calcium-binding domain-containing protein 6	DEG_SCF_FBW7_1	713:719	PPTPSKS	FBXW7	0.6473	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons