DegronMD

Uniprot ID: Q9H2E6

Source protein: Semaphorin-6A

Source gene: SEMA6A

Class: DEG_SCF_FBW7_1

Location: 755:761

E3 ligase: FBXW7

DEGRON score: 0.9956

ASA_SCORE: 64.8714

COIL: 0.905

CONS_SCORE: 0.4569

DSS_SCORE: 0.6798

HELIX: 0.04

FCONS_SCORE: 1.1512

RIG_SCORE: 0.6513

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P756L	TCGA-64-5774	LUAD	TCGA	LPTPEST	DEG_SCF_FBW7_1	0.6471
p.P756L	DO24770	LUAD	ICGC	LPTPEST	DEG_SCF_FBW7_1	0.6471
p.D751Y	TCGA-A5-A0G2	UCEC	TCGA	LPTPEST	DEG_SCF_FBW7_1	0.2222
p.D751Y	DO41235	UCEC	ICGC	LPTPEST	DEG_SCF_FBW7_1	0.2222
p.T761A	TCGA-A6-5661	COAD	TCGA	LPTPEST	DEG_SCF_FBW7_1	0.7139
p.T761A	DO8634	COAD	ICGC	LPTPEST	DEG_SCF_FBW7_1	0.7139
p.P758L	TCGA-BR-8485	STAD	TCGA	LPTPEST	DEG_SCF_FBW7_1	0.7582
p.P758L	DO47823	STAD	ICGC	LPTPEST	DEG_SCF_FBW7_1	0.7582
p.A754V	TCGA-ER-A3PL	SKCM	TCGA	LPTPEST	DEG_SCF_FBW7_1	0.3056
p.A754V	DO37495	SKCM	ICGC	LPTPEST	DEG_SCF_FBW7_1	0.3056
p.A745S	TCGA-F1-6874	STAD	TCGA	LPTPEST	DEG_SCF_FBW7_1	0.0556
p.A745S	TCGA-Q1-A5R2	CESC	TCGA	LPTPEST	DEG_SCF_FBW7_1	0.0556
p.A745S	DO49003	CESC	ICGC	LPTPEST	DEG_SCF_FBW7_1	0.0556
p.A745S	DO38201	STAD	ICGC	LPTPEST	DEG_SCF_FBW7_1	0.0556
p.P770S	TCGA-LG-A6GG	LIHC	TCGA	LPTPEST	DEG_SCF_FBW7_1	0.0833
p.P770S	DO49699	LIHC	ICGC	LPTPEST	DEG_SCF_FBW7_1	0.0833
p.L752P	TCGA-WS-AB45	COAD	TCGA	LPTPEST	DEG_SCF_FBW7_1	0.25
p.L752P	DO51734	COAD	ICGC	LPTPEST	DEG_SCF_FBW7_1	0.25
p.R768Q	DO222842	COCA	ICGC	LPTPEST	DEG_SCF_FBW7_1	0.1389
p.A750T	SIDM01307	Colorectal Carcinoma	GDSC	LPTPEST	DEG_SCF_FBW7_1	0.1944
p.A750T	SIDM00781	Colorectal Carcinoma	GDSC	LPTPEST	DEG_SCF_FBW7_1	0.1944
p.A750T	SIDM00780	Colorectal Carcinoma	GDSC	LPTPEST	DEG_SCF_FBW7_1	0.1944
p.A750T	SNU-C2B	large_intestine	COSMIC	LPTPEST	DEG_SCF_FBW7_1	0.1944
p.K748N	SIDM00571	Pancreatic Carcinoma	GDSC	LPTPEST	DEG_SCF_FBW7_1	0.1389
p.K748N	KP-3	pancreas	COSMIC	LPTPEST	DEG_SCF_FBW7_1	0.1389
p.P756R	ACH-000852	Lung Cancer	CCLE	LPTPEST	DEG_SCF_FBW7_1	0.6401
p.P756R	NCI-H1435	lung	COSMIC	LPTPEST	DEG_SCF_FBW7_1	0.6401
p.L764V	ACH-001715	Bone Cancer	CCLE	LPTPEST	DEG_SCF_FBW7_1	0.25
p.L764V	CAL-72	bone	COSMIC	LPTPEST	DEG_SCF_FBW7_1	0.25
p.T757P	ACH-002237	Bile Duct Cancer	CCLE	LPTPEST	DEG_SCF_FBW7_1	0.8142
p.L755P	MDA-MB-415	breast	COSMIC	LPTPEST	DEG_SCF_FBW7_1	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NFY4	Semaphorin-6D	DEG_SCF_FBW7_1	771:777	LPTPEST	FBXW7	0.9976	More...
Q9H2E6	Semaphorin-6A	DEG_SCF_FBW7_1	755:761	LPTPEST	FBXW7	0.9956	More...
Q9H3T2	Semaphorin-6C	DEG_SCF_FBW7_1	698:704	LPTPEST	FBXW7	0.9984	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LPTPEST

Degron related mutations and impact score

Drug responses associated with SEMA6A mutations

All proteins holding degron of LPTPEST