DegronMD

Uniprot ID: Q9H3T2

Source protein: Semaphorin-6C

Source gene: SEMA6C

Class: DEG_SCF_FBW7_1

Location: 698:704

E3 ligase: FBXW7

DEGRON score: 0.9984

ASA_SCORE: 72.7714

COIL: 0.939

CONS_SCORE: 0.367

DSS_SCORE: 0.6046

HELIX: 0.0299

FCONS_SCORE: 1.0216

RIG_SCORE: 0.67

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R688Q	TCGA-DD-AADK	LIHC	TCGA	LPTPEST	DEG_SCF_FBW7_1	0.0556
p.R713L	DO12586	GBM	ICGC	LPTPEST	DEG_SCF_FBW7_1	0.0833
p.P708S	DO229211	THCA	ICGC	LPTPEST	DEG_SCF_FBW7_1	0.2222
p.P696L	SIDM01721	Non-Cancerous	GDSC	LPTPEST	DEG_SCF_FBW7_1	0.2778
p.H711R	ACH-000937	Leukemia	CCLE	LPTPEST	DEG_SCF_FBW7_1	0.1389
p.A696V	ACH-000983	Leukemia	CCLE	LPTPEST	DEG_SCF_FBW7_1	0.2778
p.R713H	ACH-000984	Endometrial/Uterine Cancer	CCLE	LPTPEST	DEG_SCF_FBW7_1	0.0833
p.P692L	ACH-001605	Brain Cancer	CCLE	LPTPEST	DEG_SCF_FBW7_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons