DegronMD

Uniprot ID: Q8NFY4

Source protein: Semaphorin-6D

Source gene: SEMA6D

Class: DEG_SCF_FBW7_1

Location: 771:777

E3 ligase: FBXW7

DEGRON score: 0.9976

ASA_SCORE: 62.2

COIL: 0.8894

CONS_SCORE: 0.4353

DSS_SCORE: 0.7381

HELIX: 0.084

FCONS_SCORE: 1.1175

RIG_SCORE: 0.6393

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H761D	TCGA-38-4631	LUAD	TCGA	LPTPEST	DEG_SCF_FBW7_1	0.0556
p.Q764K	TCGA-38-4631	LUAD	TCGA	LPTPEST	DEG_SCF_FBW7_1	0.1389
p.A770S	TCGA-AN-A0FK	BRCA	TCGA	LPTPEST	DEG_SCF_FBW7_1	0.3056
p.A770S	SIDM01573	Plasma Cell Myeloma	GDSC	LPTPEST	DEG_SCF_FBW7_1	0.3056
p.A770S	ACH-000576	Myeloma	CCLE	LPTPEST	DEG_SCF_FBW7_1	0.3056
p.L780R	TCGA-AZ-4614	COAD	TCGA	LPTPEST	DEG_SCF_FBW7_1	0.25
p.L780R	SIDM01293	Colorectal Carcinoma	GDSC	LPTPEST	DEG_SCF_FBW7_1	0.25
p.P765L	TCGA-B5-A0JY	UCEC	TCGA	LPTPEST	DEG_SCF_FBW7_1	0.1667
p.E775G	TCGA-BR-7704	STAD	TCGA	LPTPEST	DEG_SCF_FBW7_1	0.6087
p.S780L	DO52444	COCA	ICGC	LPTPEST	DEG_SCF_FBW7_1	0.25
p.L768R	DO234259	ESAD	ICGC	LPTPEST	DEG_SCF_FBW7_1	0.25
p.A765D	DO13863	GBM	ICGC	LPTPEST	DEG_SCF_FBW7_1	0.1667
p.L768V	DO11878	GBM	ICGC	LPTPEST	DEG_SCF_FBW7_1	0.25
p.T777M	DO22237	LGG	ICGC	LPTPEST	DEG_SCF_FBW7_1	0.7423
p.T777M	T-T	oesophagus	COSMIC	LPTPEST	DEG_SCF_FBW7_1	0.7423
p.T777M	FADU	upper_aerodigestive_tract	COSMIC	LPTPEST	DEG_SCF_FBW7_1	0.7423
p.N781K	DO22994	LIHC	ICGC	LPTPEST	DEG_SCF_FBW7_1	0.2222
p.N781K	DO22857	LIHC	ICGC	LPTPEST	DEG_SCF_FBW7_1	0.2222
p.D774Y	DO23814	LUAD	ICGC	LPTPEST	DEG_SCF_FBW7_1	0.7325
p.N776S	DO23705	LUAD	ICGC	LPTPEST	DEG_SCF_FBW7_1	0.7069
p.T772I	DO41903	UCEC	ICGC	LPTPEST	DEG_SCF_FBW7_1	0.7078
p.R762Q	SIDM00773	Non-Cancerous	GDSC	LPTPEST	DEG_SCF_FBW7_1	0.0833
p.R762Q	SIDM00049	Colorectal Carcinoma	GDSC	LPTPEST	DEG_SCF_FBW7_1	0.0833
p.P765H	SIDM01136	Pancreatic Carcinoma	GDSC	LPTPEST	DEG_SCF_FBW7_1	0.1667
p.P765H	ACH-000417	Pancreatic Cancer	CCLE	LPTPEST	DEG_SCF_FBW7_1	0.1667
p.P765H	PANC-08-13	pancreas	COSMIC	LPTPEST	DEG_SCF_FBW7_1	0.1667
p.P766S	SIDM01089	B-Cell Non-Hodgkin's Lymphoma	GDSC	LPTPEST	DEG_SCF_FBW7_1	0.1944
p.P766S	ACH-000371	Lymphoma	CCLE	LPTPEST	DEG_SCF_FBW7_1	0.1944
p.P766S	RL	haematopoietic_and_lymphoid_tissue	COSMIC	LPTPEST	DEG_SCF_FBW7_1	0.1944
p.P774S	SIDM01577	Plasma Cell Myeloma	GDSC	LPTPEST	DEG_SCF_FBW7_1	0.6752
p.P774S	ACH-000889	Myeloma	CCLE	LPTPEST	DEG_SCF_FBW7_1	0.6752
p.A770T	ACH-002287	Colon/Colorectal Cancer	CCLE	LPTPEST	DEG_SCF_FBW7_1	0.3056
p.A770T	NCI-H630	large_intestine	COSMIC	LPTPEST	DEG_SCF_FBW7_1	0.3056
p.H767Y	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	LPTPEST	DEG_SCF_FBW7_1	0.2222
p.T764M	T-T	oesophagus	COSMIC	LPTPEST	DEG_SCF_FBW7_1	0.1389
p.T764M	FADU	upper_aerodigestive_tract	COSMIC	LPTPEST	DEG_SCF_FBW7_1	0.1389
p.T783M	T-T	oesophagus	COSMIC	LPTPEST	DEG_SCF_FBW7_1	0.2778
p.T783M	FADU	upper_aerodigestive_tract	COSMIC	LPTPEST	DEG_SCF_FBW7_1	0.2778
p.A784T	SW48	large_intestine	COSMIC	LPTPEST	DEG_SCF_FBW7_1	0.1389
p.H761Y	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	LPTPEST	DEG_SCF_FBW7_1	0.0556
p.A771T	SW48	large_intestine	COSMIC	LPTPEST	DEG_SCF_FBW7_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NFY4	Semaphorin-6D	DEG_SCF_FBW7_1	771:777	LPTPEST	FBXW7	0.9976	More...
Q9H2E6	Semaphorin-6A	DEG_SCF_FBW7_1	755:761	LPTPEST	FBXW7	0.9956	More...
Q9H3T2	Semaphorin-6C	DEG_SCF_FBW7_1	698:704	LPTPEST	FBXW7	0.9984	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LPTPEST

Degron related mutations and impact score

Drug responses associated with SEMA6D mutations

All proteins holding degron of LPTPEST