DegronMD - Q8NFY4(SEMA6D)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D836Y	TCGA-05-4418	LUAD	TCGA	IPSAIVLPN	DEG_SIAH_1	824:832	Mutation rewiring degron network	0.2222
p.L830V	TCGA-14-0866	GBM	TCGA	IPSAIVLPN	DEG_SIAH_1	824:832	Mutation altering degron motif	0.5654
p.P818S	TCGA-18-5592	LUSC	TCGA	IPSAIVLPN	DEG_SIAH_1	824:832	Mutation rewiring degron network	0.1667
p.P818S	TCGA-DU-A6S3	LGG	TCGA	IPSAIVLPN	DEG_SIAH_1	824:832	Mutation rewiring degron network	0.1667
p.A827D	TCGA-19-5956	GBM	TCGA	IPSAIVLPN	DEG_SIAH_1	824:832	Mutation altering degron motif	0.7793
p.H761D	TCGA-38-4631	LUAD	TCGA	LPTPEST	DEG_SCF_FBW7_1	771:777	Mutation rewiring degron network	0.0556
p.Q764K	TCGA-38-4631	LUAD	TCGA	LPTPEST	DEG_SCF_FBW7_1	771:777	Mutation rewiring degron network	0.1389
p.N838S	TCGA-50-5049	LUAD	TCGA	IPSAIVLPN	DEG_SIAH_1	824:832	Mutation rewiring degron network	0.1667
p.R871H	TCGA-73-4662	LUAD	TCGA	SRNTLNDLL	DEG_APCC_DBOX_1	875:883	Mutation rewiring degron network	0.2222
p.R871H	SIDM02013	Colorectal Carcinoma	GDSC	SRNTLNDLL	DEG_APCC_DBOX_1	875:883	Mutation rewiring degron network	0.2222
p.I603T	TCGA-A3-3358	KIRC	TCGA	VSSSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.1389
p.S593Y	TCGA-AJ-A3EL	UCEC	TCGA	VSSSS	DEG_SPOP_SBC_1	592:596	Mutation altering degron motif	0.6009
p.A770S	TCGA-AN-A0FK	BRCA	TCGA	LPTPEST	DEG_SCF_FBW7_1	771:777	Mutation rewiring degron network	0.3056
p.A770S	SIDM01573	Plasma Cell Myeloma	GDSC	LPTPEST	DEG_SCF_FBW7_1	771:777	Mutation rewiring degron network	0.3056
p.A770S	ACH-000576	Myeloma	CCLE	LPTPEST	DEG_SCF_FBW7_1	771:777	Mutation rewiring degron network	0.3056
p.P893H	TCGA-AZ-4315	COAD	TCGA	SRNTLNDLL	DEG_APCC_DBOX_1	875:883	Mutation rewiring degron network	0.0556
p.L780R	TCGA-AZ-4614	COAD	TCGA	LPTPEST	DEG_SCF_FBW7_1	771:777	Mutation rewiring degron network	0.25
p.L780R	SIDM01293	Colorectal Carcinoma	GDSC	LPTPEST	DEG_SCF_FBW7_1	771:777	Mutation rewiring degron network	0.25
p.P765L	TCGA-B5-A0JY	UCEC	TCGA	LPTPEST	DEG_SCF_FBW7_1	771:777	Mutation rewiring degron network	0.1667
p.T574A	TCGA-BG-A222	UCEC	TCGA	PTSTT	DEG_SPOP_SBC_1	573:577	Mutation altering degron motif	0.6028
p.T574A	DO42977	UCEC	ICGC	PTSTT	DEG_SPOP_SBC_1	573:577	Mutation altering degron motif	0.6028
p.E775G	TCGA-BR-7704	STAD	TCGA	LPTPEST	DEG_SCF_FBW7_1	771:777	Mutation altering degron motif	0.6087
p.N890T	TCGA-BS-A0UJ	UCEC	TCGA	SRNTLNDLL	DEG_APCC_DBOX_1	875:883	Mutation rewiring degron network	0.1389
p.R870W	TCGA-D1-A0ZO	UCEC	TCGA	SRNTLNDLL	DEG_APCC_DBOX_1	875:883	Mutation rewiring degron network	0.1944
p.T834I	TCGA-D1-A17Q	UCEC	TCGA	IPSAIVLPN	DEG_SIAH_1	824:832	Mutation rewiring degron network	0.2778
p.S872Y	TCGA-D1-A17Q	UCEC	TCGA	SRNTLNDLL	DEG_APCC_DBOX_1	875:883	Mutation rewiring degron network	0.25
p.D874G	TCGA-DB-A64L	LGG	TCGA	SRNTLNDLL	DEG_APCC_DBOX_1	875:883	Mutation rewiring degron network	0.3056
p.A563V	TCGA-DF-A2KU	UCEC	TCGA	PTSTT	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.0556
p.A563V	DO223286	UCEC	ICGC	PTSTT	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.0556
p.T839M	TCGA-DU-6392	LGG	TCGA	IPSAIVLPN	DEG_SIAH_1	824:832	Mutation rewiring degron network	0.1389
p.T839M	SIDM00322	Esophageal Squamous Cell Carcinoma	GDSC	IPSAIVLPN	DEG_SIAH_1	824:832	Mutation rewiring degron network	0.1389
p.T839M	SIDM00860	Head and Neck Carcinoma	GDSC	IPSAIVLPN	DEG_SIAH_1	824:832	Mutation rewiring degron network	0.1389
p.T839M	FADU	upper aerodigestive tract	COSMIC	IPSAIVLPN	DEG_SIAH_1	824:832	Mutation rewiring degron network	0.1389
p.T839M	T-T	oesophagus	COSMIC	IPSAIVLPN	DEG_SIAH_1	824:832	Mutation rewiring degron network	0.1389
p.T599I	TCGA-EY-A215	UCEC	TCGA	VSSSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.25
p.M600I	TCGA-WE-A8ZX	SKCM	TCGA	VSSSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.2222
p.P871L	DO816	BLCA	ICGC	SRNTLNDLL	DEG_APCC_DBOX_1	875:883	Mutation rewiring degron network	0.2222
p.G585V	DO224693	BRCA	ICGC	PTSTT	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.1111
p.G585V	DO224693	BRCA	ICGC	VSSSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.1389
p.R882Q	DO222817	BTCA	ICGC	SRNTLNDLL	DEG_APCC_DBOX_1	875:883	Mutation altering degron motif	0.7329
p.P831H	DO8842	COAD	ICGC	IPSAIVLPN	DEG_SIAH_1	824:832	Mutation altering degron motif	0.7694
p.R876I	DO8730	COAD	ICGC	SRNTLNDLL	DEG_APCC_DBOX_1	875:883	Mutation altering degron motif	0.8102
p.R876I	ACH-001853	Bile Duct Cancer	CCLE	SRNTLNDLL	DEG_APCC_DBOX_1	875:883	Mutation altering degron motif	0.8102
p.M840I	DO8264	COAD	ICGC	IPSAIVLPN	DEG_SIAH_1	824:832	Mutation rewiring degron network	0.1111
p.S780L	DO52444	COCA	ICGC	LPTPEST	DEG_SCF_FBW7_1	771:777	Mutation rewiring degron network	0.25
p.L768R	DO234259	ESAD	ICGC	LPTPEST	DEG_SCF_FBW7_1	771:777	Mutation rewiring degron network	0.25
p.C605R	DO218693	GACA	ICGC	VSSSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.0833
p.K586T	DO233193	GACA	ICGC	PTSTT	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.0833
p.K586T	DO233193	GACA	ICGC	VSSSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.1667
p.K586T	DO233694	GACA	ICGC	PTSTT	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.0833
p.K586T	DO233694	GACA	ICGC	VSSSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.1667
p.K586T	DO233874	GACA	ICGC	PTSTT	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.0833
p.K586T	DO233874	GACA	ICGC	VSSSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.1667
p.K586T	DO38296	STAD	ICGC	PTSTT	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.0833
p.K586T	DO38296	STAD	ICGC	VSSSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.1667
p.A765D	DO13863	GBM	ICGC	LPTPEST	DEG_SCF_FBW7_1	771:777	Mutation rewiring degron network	0.1667
p.L768V	DO11878	GBM	ICGC	LPTPEST	DEG_SCF_FBW7_1	771:777	Mutation rewiring degron network	0.25
p.R603Q	DO14622	HNSC	ICGC	VSSSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.1389
p.D584N	DO52073	HNSC	ICGC	PTSTT	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.1389
p.D584N	DO52073	HNSC	ICGC	VSSSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.1111
p.V891I	DO22295	LGG	ICGC	SRNTLNDLL	DEG_APCC_DBOX_1	875:883	Mutation rewiring degron network	0.1111
p.T777M	DO22237	LGG	ICGC	LPTPEST	DEG_SCF_FBW7_1	771:777	Mutation altering degron motif	0.7423
p.T777M	T-T	oesophagus	COSMIC	LPTPEST	DEG_SCF_FBW7_1	771:777	Mutation altering degron motif	0.7423
p.T777M	FADU	upper aerodigestive tract	COSMIC	LPTPEST	DEG_SCF_FBW7_1	771:777	Mutation altering degron motif	0.7423
p.S591I	DO229018	LICA	ICGC	VSSSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.3056
p.D589Y	DO229037	LICA	ICGC	VSSSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.25
p.W595C	DO229037	LICA	ICGC	VSSSS	DEG_SPOP_SBC_1	592:596	Mutation altering degron motif	0.7
p.N781K	DO22994	LIHC	ICGC	LPTPEST	DEG_SCF_FBW7_1	771:777	Mutation rewiring degron network	0.2222
p.N781K	DO22857	LIHC	ICGC	LPTPEST	DEG_SCF_FBW7_1	771:777	Mutation rewiring degron network	0.2222
p.T600K	DO52320	LIHC	ICGC	VSSSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.2222
p.G591R	DO23364	LINC	ICGC	VSSSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.3056
p.S590P	DO45061	LINC	ICGC	VSSSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.2778
p.E592K	DO229177	LMS	ICGC	VSSSS	DEG_SPOP_SBC_1	592:596	Mutation altering degron motif	0.7022
p.D774Y	DO23814	LUAD	ICGC	LPTPEST	DEG_SCF_FBW7_1	771:777	Mutation altering degron motif	0.7325
p.N776S	DO23705	LUAD	ICGC	LPTPEST	DEG_SCF_FBW7_1	771:777	Mutation altering degron motif	0.7069
p.K586M	DO26092	LUAD	ICGC	PTSTT	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.0833
p.K586M	DO26092	LUAD	ICGC	VSSSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.1667
p.G836E	DO26444	LUSC	ICGC	IPSAIVLPN	DEG_SIAH_1	824:832	Mutation rewiring degron network	0.2222
p.E590D	DO27885	ORCA	ICGC	VSSSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.2778
p.M840V	DO27937	ORCA	ICGC	IPSAIVLPN	DEG_SIAH_1	824:832	Mutation rewiring degron network	0.1111
p.V601A	DO36556	READ	ICGC	VSSSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.1944
p.K881R	DO37871	SKCM	ICGC	SRNTLNDLL	DEG_APCC_DBOX_1	875:883	Mutation altering degron motif	0.7237
p.P871S	DO37432	SKCM	ICGC	SRNTLNDLL	DEG_APCC_DBOX_1	875:883	Mutation rewiring degron network	0.2222
p.P870L	DO51286	SKCM	ICGC	SRNTLNDLL	DEG_APCC_DBOX_1	875:883	Mutation rewiring degron network	0.1944
p.M581I	DO51291	SKCM	ICGC	PTSTT	DEG_SPOP_SBC_1	573:577	Mutation substituting flanking lysine	0.3333
p.S587F	DO51783	STAD	ICGC	PTSTT	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.0556
p.S587F	DO51783	STAD	ICGC	VSSSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.1944
p.K586R	DO38241	STAD	ICGC	PTSTT	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.0833
p.K586R	DO38241	STAD	ICGC	VSSSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.1667
p.S866L	DO43306	UCEC	ICGC	SRNTLNDLL	DEG_APCC_DBOX_1	875:883	Mutation substituting flanking lysine	0.1944
p.S866L	DO41572	UCEC	ICGC	SRNTLNDLL	DEG_APCC_DBOX_1	875:883	Mutation substituting flanking lysine	0.1944
p.S866L	DO41361	UCEC	ICGC	SRNTLNDLL	DEG_APCC_DBOX_1	875:883	Mutation substituting flanking lysine	0.1944
p.S866L	REH	haematopoietic and lymphoid tissue	COSMIC	SRNTLNDLL	DEG_APCC_DBOX_1	875:883	Mutation substituting flanking lysine	0.1944
p.L867I	DO43041	UCEC	ICGC	SRNTLNDLL	DEG_APCC_DBOX_1	875:883	Mutation rewiring degron network	0.1111
p.N594D	DO41638	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	592:596	Mutation altering degron motif	0.6932
p.S574Y	DO41542	UCEC	ICGC	PTSTT	DEG_SPOP_SBC_1	573:577	Mutation altering degron motif	0.712
p.T772I	DO41903	UCEC	ICGC	LPTPEST	DEG_SCF_FBW7_1	771:777	Mutation altering degron motif	0.7078
p.R594K	DO41235	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	592:596	Mutation altering degron motif	0.7237
p.N828T	DO42745	UCEC	ICGC	IPSAIVLPN	DEG_SIAH_1	824:832	Mutation altering degron motif	0.7055
p.T580I	DO42665	UCEC	ICGC	PTSTT	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.25
p.H823Y	SIDM00946	T-Lymphoblastic Leukemia	GDSC	IPSAIVLPN	DEG_SIAH_1	824:832	Mutation rewiring degron network	0.3056
p.H823Y	ACH-000981	Leukemia	CCLE	IPSAIVLPN	DEG_SIAH_1	824:832	Mutation rewiring degron network	0.3056
p.H823Y	DND-41	haematopoietic and lymphoid tissue	COSMIC	IPSAIVLPN	DEG_SIAH_1	824:832	Mutation rewiring degron network	0.3056
p.R762Q	SIDM00773	Non-Cancerous	GDSC	LPTPEST	DEG_SCF_FBW7_1	771:777	Mutation rewiring degron network	0.0833
p.R762Q	SIDM00049	Colorectal Carcinoma	GDSC	LPTPEST	DEG_SCF_FBW7_1	771:777	Mutation rewiring degron network	0.0833
p.I571S	SIDM00845	Burkitt's Lymphoma	GDSC	PTSTT	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.2778
p.T574P	SIDM00845	Burkitt's Lymphoma	GDSC	PTSTT	DEG_SPOP_SBC_1	573:577	Mutation altering degron motif	0.5919
p.T574P	SIDM00035	Thyroid Gland Carcinoma	GDSC	PTSTT	DEG_SPOP_SBC_1	573:577	Mutation altering degron motif	0.5919
p.T574P	ACH-000786	Lymphoma	CCLE	PTSTT	DEG_SPOP_SBC_1	573:577	Mutation altering degron motif	0.5919
p.P765H	SIDM01136	Pancreatic Carcinoma	GDSC	LPTPEST	DEG_SCF_FBW7_1	771:777	Mutation rewiring degron network	0.1667
p.P765H	ACH-000417	Pancreatic Cancer	CCLE	LPTPEST	DEG_SCF_FBW7_1	771:777	Mutation rewiring degron network	0.1667
p.P765H	PANC-08-13	pancreas	COSMIC	LPTPEST	DEG_SCF_FBW7_1	771:777	Mutation rewiring degron network	0.1667
p.S891N	SIDM00530	Esophageal Carcinoma	GDSC	SRNTLNDLL	DEG_APCC_DBOX_1	875:883	Mutation rewiring degron network	0.1111
p.S891N	ACH-001544	Esophageal Cancer	CCLE	SRNTLNDLL	DEG_APCC_DBOX_1	875:883	Mutation rewiring degron network	0.1111
p.S891N	KYAE-1	oesophagus	COSMIC	SRNTLNDLL	DEG_APCC_DBOX_1	875:883	Mutation rewiring degron network	0.1111
p.G584D	SIDM00217	Colorectal Carcinoma	GDSC	PTSTT	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.1389
p.G584D	SIDM00217	Colorectal Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.1111
p.G584D	ACH-000999	Colon/Colorectal Cancer	CCLE	PTSTT	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.1389
p.G584D	ACH-000999	Colon/Colorectal Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.1111
p.G584D	SNU-1040	large intestine	COSMIC	PTSTT	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.1389
p.G584D	SNU-1040	large intestine	COSMIC	VSSSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.1111
p.P766S	SIDM01089	B-Cell Non-Hodgkin's Lymphoma	GDSC	LPTPEST	DEG_SCF_FBW7_1	771:777	Mutation rewiring degron network	0.1944
p.P766S	ACH-000371	Lymphoma	CCLE	LPTPEST	DEG_SCF_FBW7_1	771:777	Mutation rewiring degron network	0.1944
p.P766S	RL	haematopoietic and lymphoid tissue	COSMIC	LPTPEST	DEG_SCF_FBW7_1	771:777	Mutation rewiring degron network	0.1944
p.P774S	SIDM01577	Plasma Cell Myeloma	GDSC	LPTPEST	DEG_SCF_FBW7_1	771:777	Mutation altering degron motif	0.6752
p.P774S	ACH-000889	Myeloma	CCLE	LPTPEST	DEG_SCF_FBW7_1	771:777	Mutation altering degron motif	0.6752
p.A770T	ACH-002287	Colon/Colorectal Cancer	CCLE	LPTPEST	DEG_SCF_FBW7_1	771:777	Mutation rewiring degron network	0.3056
p.A770T	NCI-H630	large intestine	COSMIC	LPTPEST	DEG_SCF_FBW7_1	771:777	Mutation rewiring degron network	0.3056
p.H767Y	DND-41	haematopoietic and lymphoid tissue	COSMIC	LPTPEST	DEG_SCF_FBW7_1	771:777	Mutation rewiring degron network	0.2222
p.T764M	T-T	oesophagus	COSMIC	LPTPEST	DEG_SCF_FBW7_1	771:777	Mutation rewiring degron network	0.1389
p.T764M	FADU	upper aerodigestive tract	COSMIC	LPTPEST	DEG_SCF_FBW7_1	771:777	Mutation rewiring degron network	0.1389
p.T783M	T-T	oesophagus	COSMIC	LPTPEST	DEG_SCF_FBW7_1	771:777	Mutation substituting flanking lysine	0.2778
p.T783M	FADU	upper aerodigestive tract	COSMIC	LPTPEST	DEG_SCF_FBW7_1	771:777	Mutation substituting flanking lysine	0.2778
p.Q595K	KS-1	central nervous system	COSMIC	VSSSS	DEG_SPOP_SBC_1	592:596	Mutation altering degron motif	0.6944
p.L599F	LS-1034	large intestine	COSMIC	VSSSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.25
p.L834Q	HT55	large intestine	COSMIC	IPSAIVLPN	DEG_SIAH_1	824:832	Mutation rewiring degron network	0.2778
p.A784T	SW48	large intestine	COSMIC	LPTPEST	DEG_SCF_FBW7_1	771:777	Mutation rewiring degron network	0.1389
p.H761Y	DND-41	haematopoietic and lymphoid tissue	COSMIC	LPTPEST	DEG_SCF_FBW7_1	771:777	Mutation rewiring degron network	0.0556
p.S829N	KYAE-1	oesophagus	COSMIC	IPSAIVLPN	DEG_SIAH_1	824:832	Mutation altering degron motif	0.7069
p.S816N	KYAE-1	oesophagus	COSMIC	IPSAIVLPN	DEG_SIAH_1	824:832	Mutation rewiring degron network	0.1111
p.Q589K	KS-1	central nervous system	COSMIC	VSSSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.25
p.S835N	KYAE-1	oesophagus	COSMIC	IPSAIVLPN	DEG_SIAH_1	824:832	Mutation rewiring degron network	0.25
p.A771T	SW48	large intestine	COSMIC	LPTPEST	DEG_SCF_FBW7_1	771:777	Mutation altering degron motif	0.7139
p.S872L	REH	haematopoietic and lymphoid tissue	COSMIC	SRNTLNDLL	DEG_APCC_DBOX_1	875:883	Mutation rewiring degron network	0.25
p.Q576K	KS-1	central nervous system	COSMIC	PTSTT	DEG_SPOP_SBC_1	573:577	Mutation altering degron motif	0.6944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SEMA6D

UniProt ID: Q8NFY4

Entrez ID: 80031

Protein name: Semaphorin-6D

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SEMA6D in