DegronMD

Uniprot ID: Q8NFY4

Source protein: Semaphorin-6D

Source gene: SEMA6D

Class: DEG_SIAH_1

Location: 824:832

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9437

ASA_SCORE: 48.7444

COIL: 0.7654

CONS_SCORE: 0.3549

DSS_SCORE: 0.5253

HELIX: 0.0702

FCONS_SCORE: 0.9421

RIG_SCORE: 0.6781

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D836Y	TCGA-05-4418	LUAD	TCGA	IPSAIVLPN	DEG_SIAH_1	0.2222
p.L830V	TCGA-14-0866	GBM	TCGA	IPSAIVLPN	DEG_SIAH_1	0.5654
p.P818S	TCGA-18-5592	LUSC	TCGA	IPSAIVLPN	DEG_SIAH_1	0.1667
p.P818S	TCGA-DU-A6S3	LGG	TCGA	IPSAIVLPN	DEG_SIAH_1	0.1667
p.A827D	TCGA-19-5956	GBM	TCGA	IPSAIVLPN	DEG_SIAH_1	0.7793
p.N838S	TCGA-50-5049	LUAD	TCGA	IPSAIVLPN	DEG_SIAH_1	0.1667
p.T834I	TCGA-D1-A17Q	UCEC	TCGA	IPSAIVLPN	DEG_SIAH_1	0.2778
p.T839M	TCGA-DU-6392	LGG	TCGA	IPSAIVLPN	DEG_SIAH_1	0.1389
p.T839M	SIDM00322	Esophageal Squamous Cell Carcinoma	GDSC	IPSAIVLPN	DEG_SIAH_1	0.1389
p.T839M	SIDM00860	Head and Neck Carcinoma	GDSC	IPSAIVLPN	DEG_SIAH_1	0.1389
p.T839M	FADU	upper_aerodigestive_tract	COSMIC	IPSAIVLPN	DEG_SIAH_1	0.1389
p.T839M	T-T	oesophagus	COSMIC	IPSAIVLPN	DEG_SIAH_1	0.1389
p.P831H	DO8842	COAD	ICGC	IPSAIVLPN	DEG_SIAH_1	0.7694
p.M840I	DO8264	COAD	ICGC	IPSAIVLPN	DEG_SIAH_1	0.1111
p.G836E	DO26444	LUSC	ICGC	IPSAIVLPN	DEG_SIAH_1	0.2222
p.M840V	DO27937	ORCA	ICGC	IPSAIVLPN	DEG_SIAH_1	0.1111
p.N828T	DO42745	UCEC	ICGC	IPSAIVLPN	DEG_SIAH_1	0.7055
p.H823Y	SIDM00946	T-Lymphoblastic Leukemia	GDSC	IPSAIVLPN	DEG_SIAH_1	0.3056
p.H823Y	ACH-000981	Leukemia	CCLE	IPSAIVLPN	DEG_SIAH_1	0.3056
p.H823Y	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	IPSAIVLPN	DEG_SIAH_1	0.3056
p.L834Q	HT55	large_intestine	COSMIC	IPSAIVLPN	DEG_SIAH_1	0.2778
p.S829N	KYAE-1	oesophagus	COSMIC	IPSAIVLPN	DEG_SIAH_1	0.7069
p.S816N	KYAE-1	oesophagus	COSMIC	IPSAIVLPN	DEG_SIAH_1	0.1111
p.S835N	KYAE-1	oesophagus	COSMIC	IPSAIVLPN	DEG_SIAH_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NFY4	Semaphorin-6D	DEG_SIAH_1	824:832	IPSAIVLPN	SIAH1,SIAH2,SIAH3	0.9437	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons