DegronMD

Uniprot ID: Q8NFY4

Source protein: Semaphorin-6D

Source gene: SEMA6D

Class: DEG_APCC_DBOX_1

Location: 875:883

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9432

ASA_SCORE: 62.8222

COIL: 0.4367

CONS_SCORE: 0.3792

DSS_SCORE: 0.5787

HELIX: 0.5471

FCONS_SCORE: 1.0218

RIG_SCORE: 0.6981

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R871H	TCGA-73-4662	LUAD	TCGA	SRNTLNDLL	DEG_APCC_DBOX_1	0.2222
p.R871H	SIDM02013	Colorectal Carcinoma	GDSC	SRNTLNDLL	DEG_APCC_DBOX_1	0.2222
p.P893H	TCGA-AZ-4315	COAD	TCGA	SRNTLNDLL	DEG_APCC_DBOX_1	0.0556
p.N890T	TCGA-BS-A0UJ	UCEC	TCGA	SRNTLNDLL	DEG_APCC_DBOX_1	0.1389
p.R870W	TCGA-D1-A0ZO	UCEC	TCGA	SRNTLNDLL	DEG_APCC_DBOX_1	0.1944
p.S872Y	TCGA-D1-A17Q	UCEC	TCGA	SRNTLNDLL	DEG_APCC_DBOX_1	0.25
p.D874G	TCGA-DB-A64L	LGG	TCGA	SRNTLNDLL	DEG_APCC_DBOX_1	0.3056
p.P871L	DO816	BLCA	ICGC	SRNTLNDLL	DEG_APCC_DBOX_1	0.2222
p.R882Q	DO222817	BTCA	ICGC	SRNTLNDLL	DEG_APCC_DBOX_1	0.7329
p.R876I	DO8730	COAD	ICGC	SRNTLNDLL	DEG_APCC_DBOX_1	0.8102
p.R876I	ACH-001853	Bile Duct Cancer	CCLE	SRNTLNDLL	DEG_APCC_DBOX_1	0.8102
p.V891I	DO22295	LGG	ICGC	SRNTLNDLL	DEG_APCC_DBOX_1	0.1111
p.K881R	DO37871	SKCM	ICGC	SRNTLNDLL	DEG_APCC_DBOX_1	0.7237
p.P871S	DO37432	SKCM	ICGC	SRNTLNDLL	DEG_APCC_DBOX_1	0.2222
p.P870L	DO51286	SKCM	ICGC	SRNTLNDLL	DEG_APCC_DBOX_1	0.1944
p.S866L	DO43306	UCEC	ICGC	SRNTLNDLL	DEG_APCC_DBOX_1	0.1944
p.S866L	DO41572	UCEC	ICGC	SRNTLNDLL	DEG_APCC_DBOX_1	0.1944
p.S866L	DO41361	UCEC	ICGC	SRNTLNDLL	DEG_APCC_DBOX_1	0.1944
p.S866L	REH	haematopoietic_and_lymphoid_tissue	COSMIC	SRNTLNDLL	DEG_APCC_DBOX_1	0.1944
p.L867I	DO43041	UCEC	ICGC	SRNTLNDLL	DEG_APCC_DBOX_1	0.1111
p.S891N	SIDM00530	Esophageal Carcinoma	GDSC	SRNTLNDLL	DEG_APCC_DBOX_1	0.1111
p.S891N	ACH-001544	Esophageal Cancer	CCLE	SRNTLNDLL	DEG_APCC_DBOX_1	0.1111
p.S891N	KYAE-1	oesophagus	COSMIC	SRNTLNDLL	DEG_APCC_DBOX_1	0.1111
p.S872L	REH	haematopoietic_and_lymphoid_tissue	COSMIC	SRNTLNDLL	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NFY4	Semaphorin-6D	DEG_APCC_DBOX_1	875:883	SRNTLNDLL	APC,CDC20,FZR1	0.9432	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons