DegronMD

Uniprot ID: Q8NFY4

Source protein: Semaphorin-6D

Source gene: SEMA6D

Class: DEG_SPOP_SBC_1

Location: 573:577

E3 ligase: SPOP

DEGRON score: 0.9915

ASA_SCORE: 81.96

COIL: 0.9196

CONS_SCORE: 0.365

DSS_SCORE: 0.4183

HELIX: 0.0244

FCONS_SCORE: 0.8351

RIG_SCORE: 0.7453

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T574A	TCGA-BG-A222	UCEC	TCGA	PTSTT	DEG_SPOP_SBC_1	0.6028
p.T574A	DO42977	UCEC	ICGC	PTSTT	DEG_SPOP_SBC_1	0.6028
p.A563V	TCGA-DF-A2KU	UCEC	TCGA	PTSTT	DEG_SPOP_SBC_1	0.0556
p.A563V	DO223286	UCEC	ICGC	PTSTT	DEG_SPOP_SBC_1	0.0556
p.G585V	DO224693	BRCA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.1111
p.K586T	DO233193	GACA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.0833
p.K586T	DO233694	GACA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.0833
p.K586T	DO233874	GACA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.0833
p.K586T	DO38296	STAD	ICGC	PTSTT	DEG_SPOP_SBC_1	0.0833
p.D584N	DO52073	HNSC	ICGC	PTSTT	DEG_SPOP_SBC_1	0.1389
p.K586M	DO26092	LUAD	ICGC	PTSTT	DEG_SPOP_SBC_1	0.0833
p.M581I	DO51291	SKCM	ICGC	PTSTT	DEG_SPOP_SBC_1	0.3333
p.S587F	DO51783	STAD	ICGC	PTSTT	DEG_SPOP_SBC_1	0.0556
p.K586R	DO38241	STAD	ICGC	PTSTT	DEG_SPOP_SBC_1	0.0833
p.S574Y	DO41542	UCEC	ICGC	PTSTT	DEG_SPOP_SBC_1	0.712
p.T580I	DO42665	UCEC	ICGC	PTSTT	DEG_SPOP_SBC_1	0.25
p.I571S	SIDM00845	Burkitt's Lymphoma	GDSC	PTSTT	DEG_SPOP_SBC_1	0.2778
p.T574P	SIDM00845	Burkitt's Lymphoma	GDSC	PTSTT	DEG_SPOP_SBC_1	0.5919
p.T574P	SIDM00035	Thyroid Gland Carcinoma	GDSC	PTSTT	DEG_SPOP_SBC_1	0.5919
p.T574P	ACH-000786	Lymphoma	CCLE	PTSTT	DEG_SPOP_SBC_1	0.5919
p.G584D	SIDM00217	Colorectal Carcinoma	GDSC	PTSTT	DEG_SPOP_SBC_1	0.1389
p.G584D	ACH-000999	Colon/Colorectal Cancer	CCLE	PTSTT	DEG_SPOP_SBC_1	0.1389
p.G584D	SNU-1040	large_intestine	COSMIC	PTSTT	DEG_SPOP_SBC_1	0.1389
p.Q576K	KS-1	central_nervous_system	COSMIC	PTSTT	DEG_SPOP_SBC_1	0.6944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75175	CCR4-NOT transcription complex subunit 3	DEG_SPOP_SBC_1	261:265	PTSTT	SPOP	0.9957	More...
O95274	Ly6/PLAUR domain-containing protein 3	DEG_SPOP_SBC_1	265:269	PTSTT	SPOP	0.6057	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1269:1273	PTSTT	SPOP	0.8061	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3449:3453	PTSTT	SPOP	0.9952	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1539:1543	PTSTT	SPOP	0.9933	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1932:1936	PTSTT	SPOP	0.7189	More...
Q8IZF6	Adhesion G-protein coupled receptor G4	DEG_SPOP_SBC_1	638:642	PTSTT	SPOP	0.5747	More...
Q8NFY4	Semaphorin-6D	DEG_SPOP_SBC_1	573:577	PTSTT	SPOP	0.9915	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	741:745	PTSTT	SPOP	0.9471	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	810:814	PTSTT	SPOP	0.9461	More...
Q96LM5	Uncharacterized protein C4orf45	DEG_SPOP_SBC_1	9:13	PTSTT	SPOP	0.8223	More...
Q9H2X6	Homeodomain-interacting protein kinase 2	DEG_SPOP_SBC_1	795:799	PTSTT	SPOP	0.9575	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	1885:1889	PTSTT	SPOP	0.9877	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	2005:2009	PTSTT	SPOP	0.9831	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	2046:2050	PTSTT	SPOP	0.9546	More...
Q9UBL0	cAMP-regulated phosphoprotein 21	DEG_SPOP_SBC_1	647:651	PTSTT	SPOP	0.7583	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons