DegronMD

Uniprot ID: Q92954

Source protein: Proteoglycan 4

Source gene: PRG4

Class: DEG_SPOP_SBC_1

Location: 741:745

E3 ligase: SPOP

DEGRON score: 0.9471

ASA_SCORE: 96.66

COIL: 0.9576

CONS_SCORE: 0.161

DSS_SCORE: 0.7987

HELIX: 0.0176

FCONS_SCORE: 0.6836

RIG_SCORE: 0.5587

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C746S	DO229010	COCA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.3056
p.C746S	DO229013	COCA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.3056
p.C746S	DO229016	COCA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.3056
p.C746S	DO229003	COCA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.3056
p.C746S	DO229005	COCA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.3056
p.L733P	DO228945	LICA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.1111
p.L733P	DO224610	LUSC	ICGC	PTSTT	DEG_SPOP_SBC_1	0.1111
p.E740G	DO50827	LIRI	ICGC	PTSTT	DEG_SPOP_SBC_1	0.3056
p.A750T	SIDM00392	Melanoma	GDSC	PTSTT	DEG_SPOP_SBC_1	0.1944
p.A750T	SIDM00025	Head and Neck Carcinoma	GDSC	PTSTT	DEG_SPOP_SBC_1	0.1944
p.A750T	SIDM00789	Colorectal Carcinoma	GDSC	PTSTT	DEG_SPOP_SBC_1	0.1944
p.A750T	SIDM01168	Colorectal Carcinoma	GDSC	PTSTT	DEG_SPOP_SBC_1	0.1944
p.A750T	SIDM00966	Ovarian Carcinoma	GDSC	PTSTT	DEG_SPOP_SBC_1	0.1944
p.A750T	SIDM00112	Kidney Carcinoma	GDSC	PTSTT	DEG_SPOP_SBC_1	0.1944
p.A750T	SIDM00918	Ovarian Carcinoma	GDSC	PTSTT	DEG_SPOP_SBC_1	0.1944
p.T742A	ACH-002287	Colon/Colorectal Cancer	CCLE	PTSTT	DEG_SPOP_SBC_1	0.6028
p.T742A	NCI-H630	large_intestine	COSMIC	PTSTT	DEG_SPOP_SBC_1	0.6028
p.P732T	SK-MEL-30	skin	COSMIC	PTSTT	DEG_SPOP_SBC_1	0.0833
p.P732T	UACC-62	skin	COSMIC	PTSTT	DEG_SPOP_SBC_1	0.0833
p.P732T	JURL-MK1	haematopoietic_and_lymphoid_tissue	COSMIC	PTSTT	DEG_SPOP_SBC_1	0.0833
p.E731G	SK-MEL-30	skin	COSMIC	PTSTT	DEG_SPOP_SBC_1	0.1667
p.E731G	UACC-62	skin	COSMIC	PTSTT	DEG_SPOP_SBC_1	0.1667
p.E731G	JURL-MK1	haematopoietic_and_lymphoid_tissue	COSMIC	PTSTT	DEG_SPOP_SBC_1	0.1667
p.E747K	Sarc9371	bone	COSMIC	PTSTT	DEG_SPOP_SBC_1	0.2778
p.E745K	Sarc9371	bone	COSMIC	PTSTT	DEG_SPOP_SBC_1	0.7022
p.E731K	NCI-H1573	lung	COSMIC	PTSTT	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75175	CCR4-NOT transcription complex subunit 3	DEG_SPOP_SBC_1	261:265	PTSTT	SPOP	0.9957	More...
O95274	Ly6/PLAUR domain-containing protein 3	DEG_SPOP_SBC_1	265:269	PTSTT	SPOP	0.6057	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1269:1273	PTSTT	SPOP	0.8061	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3449:3453	PTSTT	SPOP	0.9952	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1539:1543	PTSTT	SPOP	0.9933	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1932:1936	PTSTT	SPOP	0.7189	More...
Q8IZF6	Adhesion G-protein coupled receptor G4	DEG_SPOP_SBC_1	638:642	PTSTT	SPOP	0.5747	More...
Q8NFY4	Semaphorin-6D	DEG_SPOP_SBC_1	573:577	PTSTT	SPOP	0.9915	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	741:745	PTSTT	SPOP	0.9471	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	810:814	PTSTT	SPOP	0.9461	More...
Q96LM5	Uncharacterized protein C4orf45	DEG_SPOP_SBC_1	9:13	PTSTT	SPOP	0.8223	More...
Q9H2X6	Homeodomain-interacting protein kinase 2	DEG_SPOP_SBC_1	795:799	PTSTT	SPOP	0.9575	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	1885:1889	PTSTT	SPOP	0.9877	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	2005:2009	PTSTT	SPOP	0.9831	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	2046:2050	PTSTT	SPOP	0.9546	More...
Q9UBL0	cAMP-regulated phosphoprotein 21	DEG_SPOP_SBC_1	647:651	PTSTT	SPOP	0.7583	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTSTT

Degron related mutations and impact score

Drug responses associated with PRG4 mutations

All proteins holding degron of PTSTT