DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SPOP_SBC_1

Location: 1269:1273

E3 ligase: SPOP

DEGRON score: 0.8061

ASA_SCORE: 90.84

COIL: 0.9242

CONS_SCORE: 0.5236

DSS_SCORE: 0.6392

HELIX: 0.0182

FCONS_SCORE: 1

RIG_SCORE: 0.656

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I1283M	TCGA-17-Z000	LUAD	TCGA	PTSTT	DEG_SPOP_SBC_1	0.0556
p.T1261A	TCGA-17-Z045	LUAD	TCGA	PTSTT	DEG_SPOP_SBC_1	0.1111
p.G1265V	TCGA-61-2102	OV	TCGA	PTSTT	DEG_SPOP_SBC_1	0.2222
p.G1265V	DO31939	OV	ICGC	PTSTT	DEG_SPOP_SBC_1	0.2222
p.S1274T	TCGA-AA-3697	COAD	TCGA	PTSTT	DEG_SPOP_SBC_1	0.3056
p.S1274T	DO8424	COAD	ICGC	PTSTT	DEG_SPOP_SBC_1	0.3056
p.S1274T	SIDM00831	Head and Neck Carcinoma	GDSC	PTSTT	DEG_SPOP_SBC_1	0.3056
p.S1274T	ACH-000207	Head and Neck Cancer	CCLE	PTSTT	DEG_SPOP_SBC_1	0.3056
p.S1274T	Detroit562	upper_aerodigestive_tract	COSMIC	PTSTT	DEG_SPOP_SBC_1	0.3056
p.L1279I	TCGA-AG-A002	READ	TCGA	PTSTT	DEG_SPOP_SBC_1	0.1667
p.A1263V	TCGA-EJ-7218	PRAD	TCGA	PTSTT	DEG_SPOP_SBC_1	0.1667
p.A1263V	DO51310	PRAD	ICGC	PTSTT	DEG_SPOP_SBC_1	0.1667
p.G1276E	TCGA-FS-A4F8	SKCM	TCGA	PTSTT	DEG_SPOP_SBC_1	0.25
p.G1276E	DO38117	SKCM	ICGC	PTSTT	DEG_SPOP_SBC_1	0.25
p.T1266S	TCGA-V1-A8WW	PRAD	TCGA	PTSTT	DEG_SPOP_SBC_1	0.25
p.T1266S	DO219365	PRAD	ICGC	PTSTT	DEG_SPOP_SBC_1	0.25
p.P1260R	DO222414	BTCA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.0833
p.T1262S	DO224735	COCA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.1389
p.T1262S	DO222553	COCA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.1389
p.T1262S	DO222737	COCA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.1389
p.T1262S	DO229013	COCA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.1389
p.T1262S	DO229016	COCA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.1389
p.S1277I	DO222553	COCA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.2222
p.S1277I	DO229013	COCA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.2222
p.S1277I	DO229016	COCA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.2222
p.S1277I	DO52365	LUSC	ICGC	PTSTT	DEG_SPOP_SBC_1	0.2222
p.E1275K	DO229456	SKCA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.2778
p.S1267R	SIDM00087	Plasma Cell Myeloma	GDSC	PTSTT	DEG_SPOP_SBC_1	0.2778
p.S1267R	SIDM00694	Other Solid Cancers	GDSC	PTSTT	DEG_SPOP_SBC_1	0.2778
p.S1267R	SIDM01409	Bladder Carcinoma	GDSC	PTSTT	DEG_SPOP_SBC_1	0.2778
p.S1282C	SIDM00653	Small Cell Lung Carcinoma	GDSC	PTSTT	DEG_SPOP_SBC_1	0.0833
p.S1282C	NCI-H1092	lung	COSMIC	PTSTT	DEG_SPOP_SBC_1	0.0833
p.L1268F	SIDM00665	Gastric Carcinoma	GDSC	PTSTT	DEG_SPOP_SBC_1	0.3056
p.L1268F	ACH-000616	Gastric Cancer	CCLE	PTSTT	DEG_SPOP_SBC_1	0.3056
p.L1268F	Hs746T	stomach	COSMIC	PTSTT	DEG_SPOP_SBC_1	0.3056
p.P1269A	SIDM00217	Colorectal Carcinoma	GDSC	PTSTT	DEG_SPOP_SBC_1	0.6392
p.P1269A	ACH-000999	Colon/Colorectal Cancer	CCLE	PTSTT	DEG_SPOP_SBC_1	0.6392
p.P1269A	SNU-1040	large_intestine	COSMIC	PTSTT	DEG_SPOP_SBC_1	0.6392
p.G1276R	ACH-002061	Leukemia	CCLE	PTSTT	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75175	CCR4-NOT transcription complex subunit 3	DEG_SPOP_SBC_1	261:265	PTSTT	SPOP	0.9957	More...
O95274	Ly6/PLAUR domain-containing protein 3	DEG_SPOP_SBC_1	265:269	PTSTT	SPOP	0.6057	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1269:1273	PTSTT	SPOP	0.8061	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3449:3453	PTSTT	SPOP	0.9952	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1539:1543	PTSTT	SPOP	0.9933	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1932:1936	PTSTT	SPOP	0.7189	More...
Q8IZF6	Adhesion G-protein coupled receptor G4	DEG_SPOP_SBC_1	638:642	PTSTT	SPOP	0.5747	More...
Q8NFY4	Semaphorin-6D	DEG_SPOP_SBC_1	573:577	PTSTT	SPOP	0.9915	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	741:745	PTSTT	SPOP	0.9471	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	810:814	PTSTT	SPOP	0.9461	More...
Q96LM5	Uncharacterized protein C4orf45	DEG_SPOP_SBC_1	9:13	PTSTT	SPOP	0.8223	More...
Q9H2X6	Homeodomain-interacting protein kinase 2	DEG_SPOP_SBC_1	795:799	PTSTT	SPOP	0.9575	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	1885:1889	PTSTT	SPOP	0.9877	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	2005:2009	PTSTT	SPOP	0.9831	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	2046:2050	PTSTT	SPOP	0.9546	More...
Q9UBL0	cAMP-regulated phosphoprotein 21	DEG_SPOP_SBC_1	647:651	PTSTT	SPOP	0.7583	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTSTT

Degron related mutations and impact score

Drug responses associated with MUC17 mutations

All proteins holding degron of PTSTT