DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SPOP_SBC_1

Location: 3449:3453

E3 ligase: SPOP

DEGRON score: 0.9952

ASA_SCORE: 85.04

COIL: 0.8642

CONS_SCORE: 0.8457

DSS_SCORE: 0.6581

HELIX: 0.0158

FCONS_SCORE: 1.4956

RIG_SCORE: 0.6394

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A3443V	TCGA-91-6831	LUAD	TCGA	PTSTT	DEG_SPOP_SBC_1	0.1667
p.A3443V	DO23753	LUAD	ICGC	PTSTT	DEG_SPOP_SBC_1	0.1667
p.S3447I	TCGA-EY-A215	UCEC	TCGA	PTSTT	DEG_SPOP_SBC_1	0.2778
p.S3447I	DO42665	UCEC	ICGC	PTSTT	DEG_SPOP_SBC_1	0.2778
p.P3440S	TCGA-GN-A26C	SKCM	TCGA	PTSTT	DEG_SPOP_SBC_1	0.0833
p.P3440S	DO37782	SKCM	ICGC	PTSTT	DEG_SPOP_SBC_1	0.0833
p.S3451A	TCGA-Q9-A6FW	ESCA	TCGA	PTSTT	DEG_SPOP_SBC_1	0.7588
p.S3447T	DO228483	BRCA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.2778
p.S3447T	SIDM00377	Other Sarcomas	GDSC	PTSTT	DEG_SPOP_SBC_1	0.2778
p.S3447T	SIDM00568	Gastric Carcinoma	GDSC	PTSTT	DEG_SPOP_SBC_1	0.2778
p.S3447T	SIDM00556	Neuroblastoma	GDSC	PTSTT	DEG_SPOP_SBC_1	0.2778
p.S3447T	SIDM00817	Kidney Carcinoma	GDSC	PTSTT	DEG_SPOP_SBC_1	0.2778
p.S3447T	SIDM01180	Hepatocellular Carcinoma	GDSC	PTSTT	DEG_SPOP_SBC_1	0.2778
p.S3447T	SKN	soft_tissue	COSMIC	PTSTT	DEG_SPOP_SBC_1	0.2778
p.S3447T	OCUM-1	stomach	COSMIC	PTSTT	DEG_SPOP_SBC_1	0.2778
p.S3447T	SNU-387	liver	COSMIC	PTSTT	DEG_SPOP_SBC_1	0.2778
p.S3447T	KP-N-YN	autonomic_ganglia	COSMIC	PTSTT	DEG_SPOP_SBC_1	0.2778
p.T3458A	DO223009	ESCA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.1944
p.P3459L	DO222521	MELA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.1667
p.T3453S	SIDM01126	Small Cell Lung Carcinoma	GDSC	PTSTT	DEG_SPOP_SBC_1	0.6005
p.T3453S	SIDM01147	Gastric Carcinoma	GDSC	PTSTT	DEG_SPOP_SBC_1	0.6005
p.S3457N	SIDM00654	Small Cell Lung Carcinoma	GDSC	PTSTT	DEG_SPOP_SBC_1	0.2222
p.T3441A	SIDM00290	Gastric Carcinoma	GDSC	PTSTT	DEG_SPOP_SBC_1	0.1111
p.T3441A	ACH-000847	Gastric Cancer	CCLE	PTSTT	DEG_SPOP_SBC_1	0.1111
p.T3441A	HGC-27	stomach	COSMIC	PTSTT	DEG_SPOP_SBC_1	0.1111
p.P3459A	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	PTSTT	DEG_SPOP_SBC_1	0.1667
p.P3459A	ACH-000694	Esophageal Cancer	CCLE	PTSTT	DEG_SPOP_SBC_1	0.1667
p.P3459A	TE-9	oesophagus	COSMIC	PTSTT	DEG_SPOP_SBC_1	0.1667
p.S3461L	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	PTSTT	DEG_SPOP_SBC_1	0.1111
p.S3461L	ACH-000694	Esophageal Cancer	CCLE	PTSTT	DEG_SPOP_SBC_1	0.1111
p.S3461L	TE-9	oesophagus	COSMIC	PTSTT	DEG_SPOP_SBC_1	0.1111
p.G3456E	ACH-001982	Metastasis	CCLE	PTSTT	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75175	CCR4-NOT transcription complex subunit 3	DEG_SPOP_SBC_1	261:265	PTSTT	SPOP	0.9957	More...
O95274	Ly6/PLAUR domain-containing protein 3	DEG_SPOP_SBC_1	265:269	PTSTT	SPOP	0.6057	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1269:1273	PTSTT	SPOP	0.8061	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3449:3453	PTSTT	SPOP	0.9952	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1539:1543	PTSTT	SPOP	0.9933	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1932:1936	PTSTT	SPOP	0.7189	More...
Q8IZF6	Adhesion G-protein coupled receptor G4	DEG_SPOP_SBC_1	638:642	PTSTT	SPOP	0.5747	More...
Q8NFY4	Semaphorin-6D	DEG_SPOP_SBC_1	573:577	PTSTT	SPOP	0.9915	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	741:745	PTSTT	SPOP	0.9471	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	810:814	PTSTT	SPOP	0.9461	More...
Q96LM5	Uncharacterized protein C4orf45	DEG_SPOP_SBC_1	9:13	PTSTT	SPOP	0.8223	More...
Q9H2X6	Homeodomain-interacting protein kinase 2	DEG_SPOP_SBC_1	795:799	PTSTT	SPOP	0.9575	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	1885:1889	PTSTT	SPOP	0.9877	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	2005:2009	PTSTT	SPOP	0.9831	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	2046:2050	PTSTT	SPOP	0.9546	More...
Q9UBL0	cAMP-regulated phosphoprotein 21	DEG_SPOP_SBC_1	647:651	PTSTT	SPOP	0.7583	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTSTT

Degron related mutations and impact score

Drug responses associated with MUC17 mutations

All proteins holding degron of PTSTT