DegronMD

Uniprot ID: Q6W4X9

Source protein: Mucin-6

Source gene: MUC6

Class: DEG_SPOP_SBC_1

Location: 1932:1936

E3 ligase: SPOP

DEGRON score: 0.7189

ASA_SCORE: 89.66

COIL: 0.8778

CONS_SCORE: 0.334

DSS_SCORE: 0.7082

HELIX: 0.0158

FCONS_SCORE: 1.1471

RIG_SCORE: 0.6313

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1946D	DO224744	COCA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.0556
p.T1922I	DO224817	COCA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.0556
p.T1922I	DO222800	COCA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.0556
p.H1942P	DO229010	COCA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.1667
p.H1942P	DO229013	COCA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.1667
p.H1942P	DO229016	COCA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.1667
p.H1942P	DO229003	COCA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.1667
p.H1942P	DO229005	COCA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.1667
p.N1937T	DO229010	COCA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.3056
p.N1937T	DO229013	COCA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.3056
p.N1937T	DO229003	COCA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.3056
p.N1937T	DO229268	THCA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.3056
p.K1941N	DO229010	COCA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.3056
p.K1941N	DO229013	COCA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.3056
p.K1941N	DO229003	COCA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.3056
p.S1934Y	SIDM00475	Ovarian Carcinoma	GDSC	PTSTT	DEG_SPOP_SBC_1	0.712
p.S1934Y	ACH-000091	Ovarian Cancer	CCLE	PTSTT	DEG_SPOP_SBC_1	0.712
p.S1934Y	OV-56	ovary	COSMIC	PTSTT	DEG_SPOP_SBC_1	0.712
p.T1945K	SIDM00121	T-Lymphoblastic Leukemia	GDSC	PTSTT	DEG_SPOP_SBC_1	0.0833
p.T1945K	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	PTSTT	DEG_SPOP_SBC_1	0.0833
p.G1946C	SNU-C5	large_intestine	COSMIC	PTSTT	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75175	CCR4-NOT transcription complex subunit 3	DEG_SPOP_SBC_1	261:265	PTSTT	SPOP	0.9957	More...
O95274	Ly6/PLAUR domain-containing protein 3	DEG_SPOP_SBC_1	265:269	PTSTT	SPOP	0.6057	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1269:1273	PTSTT	SPOP	0.8061	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3449:3453	PTSTT	SPOP	0.9952	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1539:1543	PTSTT	SPOP	0.9933	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1932:1936	PTSTT	SPOP	0.7189	More...
Q8IZF6	Adhesion G-protein coupled receptor G4	DEG_SPOP_SBC_1	638:642	PTSTT	SPOP	0.5747	More...
Q8NFY4	Semaphorin-6D	DEG_SPOP_SBC_1	573:577	PTSTT	SPOP	0.9915	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	741:745	PTSTT	SPOP	0.9471	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	810:814	PTSTT	SPOP	0.9461	More...
Q96LM5	Uncharacterized protein C4orf45	DEG_SPOP_SBC_1	9:13	PTSTT	SPOP	0.8223	More...
Q9H2X6	Homeodomain-interacting protein kinase 2	DEG_SPOP_SBC_1	795:799	PTSTT	SPOP	0.9575	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	1885:1889	PTSTT	SPOP	0.9877	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	2005:2009	PTSTT	SPOP	0.9831	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	2046:2050	PTSTT	SPOP	0.9546	More...
Q9UBL0	cAMP-regulated phosphoprotein 21	DEG_SPOP_SBC_1	647:651	PTSTT	SPOP	0.7583	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons