DegronMD

Uniprot ID: Q9UBL0

Source protein: cAMP-regulated phosphoprotein 21

Source gene: ARPP21

Class: DEG_SPOP_SBC_1

Location: 647:651

E3 ligase: SPOP

DEGRON score: 0.7583

ASA_SCORE: 68.72

COIL: 0.82

CONS_SCORE: 0.4557

DSS_SCORE: 0.5023

HELIX: 0.129

FCONS_SCORE: 0.9072

RIG_SCORE: 0.683

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T652M	TCGA-29-1701	OV	TCGA	PTSTT	DEG_SPOP_SBC_1	0.3056
p.T652M	TCGA-75-6203	LUAD	TCGA	PTSTT	DEG_SPOP_SBC_1	0.3056
p.T652M	TCGA-AX-A2HC	UCEC	TCGA	PTSTT	DEG_SPOP_SBC_1	0.3056
p.T652M	DO25887	LUAD	ICGC	PTSTT	DEG_SPOP_SBC_1	0.3056
p.T652M	DO29830	OV	ICGC	PTSTT	DEG_SPOP_SBC_1	0.3056
p.T652M	DO41572	UCEC	ICGC	PTSTT	DEG_SPOP_SBC_1	0.3056
p.G645D	TCGA-A5-A0G1	UCEC	TCGA	PTSTT	DEG_SPOP_SBC_1	0.2778
p.G645D	DO42472	UCEC	ICGC	PTSTT	DEG_SPOP_SBC_1	0.2778
p.P660L	TCGA-AA-A01Z	COAD	TCGA	PTSTT	DEG_SPOP_SBC_1	0.0833
p.P660L	DO8392	COAD	ICGC	PTSTT	DEG_SPOP_SBC_1	0.0833
p.P660L	DO222778	COCA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.0833
p.R656W	TCGA-FU-A3HZ	CESC	TCGA	PTSTT	DEG_SPOP_SBC_1	0.1944
p.R656W	DO6308	CESC	ICGC	PTSTT	DEG_SPOP_SBC_1	0.1944
p.R656W	SIDM00438	B-Lymphoblastic Leukemia	GDSC	PTSTT	DEG_SPOP_SBC_1	0.1944
p.R656W	MN-60	haematopoietic_and_lymphoid_tissue	COSMIC	PTSTT	DEG_SPOP_SBC_1	0.1944
p.P643T	TCGA-G4-6309	COAD	TCGA	PTSTT	DEG_SPOP_SBC_1	0.2222
p.P643T	DO7810	COAD	ICGC	PTSTT	DEG_SPOP_SBC_1	0.2222
p.Q654K	TCGA-VQ-A8PD	STAD	TCGA	PTSTT	DEG_SPOP_SBC_1	0.25
p.Q654K	DO51768	STAD	ICGC	PTSTT	DEG_SPOP_SBC_1	0.25
p.T651A	TCGA-VQ-A91D	STAD	TCGA	PTSTT	DEG_SPOP_SBC_1	0.7139
p.T651A	DO51783	STAD	ICGC	PTSTT	DEG_SPOP_SBC_1	0.7139
p.M637I	DO229009	LICA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.0556
p.P660R	SIDM00960	Colorectal Carcinoma	GDSC	PTSTT	DEG_SPOP_SBC_1	0.0833
p.P660R	CL-40	large_intestine	COSMIC	PTSTT	DEG_SPOP_SBC_1	0.0833
p.P643S	SIDM00007	Other Solid Cancers	GDSC	PTSTT	DEG_SPOP_SBC_1	0.2222
p.P643S	MCC13	skin	COSMIC	PTSTT	DEG_SPOP_SBC_1	0.2222
p.M657K	ACH-000296	Colon/Colorectal Cancer	CCLE	PTSTT	DEG_SPOP_SBC_1	0.1667
p.P659R	ACH-000798	Colon/Colorectal Cancer	CCLE	PTSTT	DEG_SPOP_SBC_1	0.1111
p.P659R	CL-40	large_intestine	COSMIC	PTSTT	DEG_SPOP_SBC_1	0.1111
p.P642S	ACH-001550	Skin Cancer	CCLE	PTSTT	DEG_SPOP_SBC_1	0.1944
p.P642S	MCC13	skin	COSMIC	PTSTT	DEG_SPOP_SBC_1	0.1944
p.R655W	ACH-002275	Leukemia	CCLE	PTSTT	DEG_SPOP_SBC_1	0.2222
p.R655W	MN-60	haematopoietic_and_lymphoid_tissue	COSMIC	PTSTT	DEG_SPOP_SBC_1	0.2222
p.G644C	SW13	adrenal_gland	COSMIC	PTSTT	DEG_SPOP_SBC_1	0.25
p.R647K	KYSE-150	oesophagus	COSMIC	PTSTT	DEG_SPOP_SBC_1	0.7237
p.A654P	A4-Fuk	haematopoietic_and_lymphoid_tissue	COSMIC	PTSTT	DEG_SPOP_SBC_1	0.25
p.G645C	SW13	adrenal_gland	COSMIC	PTSTT	DEG_SPOP_SBC_1	0.2778
p.P640R	CL-40	large_intestine	COSMIC	PTSTT	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75175	CCR4-NOT transcription complex subunit 3	DEG_SPOP_SBC_1	261:265	PTSTT	SPOP	0.9957	More...
O95274	Ly6/PLAUR domain-containing protein 3	DEG_SPOP_SBC_1	265:269	PTSTT	SPOP	0.6057	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1269:1273	PTSTT	SPOP	0.8061	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3449:3453	PTSTT	SPOP	0.9952	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1539:1543	PTSTT	SPOP	0.9933	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1932:1936	PTSTT	SPOP	0.7189	More...
Q8IZF6	Adhesion G-protein coupled receptor G4	DEG_SPOP_SBC_1	638:642	PTSTT	SPOP	0.5747	More...
Q8NFY4	Semaphorin-6D	DEG_SPOP_SBC_1	573:577	PTSTT	SPOP	0.9915	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	741:745	PTSTT	SPOP	0.9471	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	810:814	PTSTT	SPOP	0.9461	More...
Q96LM5	Uncharacterized protein C4orf45	DEG_SPOP_SBC_1	9:13	PTSTT	SPOP	0.8223	More...
Q9H2X6	Homeodomain-interacting protein kinase 2	DEG_SPOP_SBC_1	795:799	PTSTT	SPOP	0.9575	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	1885:1889	PTSTT	SPOP	0.9877	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	2005:2009	PTSTT	SPOP	0.9831	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	2046:2050	PTSTT	SPOP	0.9546	More...
Q9UBL0	cAMP-regulated phosphoprotein 21	DEG_SPOP_SBC_1	647:651	PTSTT	SPOP	0.7583	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTSTT

Degron related mutations and impact score

Drug responses associated with ARPP21 mutations

All proteins holding degron of PTSTT