DegronMD - Q96LM5(C4orf45)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T12N	TCGA-5U-AB0D	THYM	TCGA	PTSTT	DEG_SPOP_SBC_1	9:13	Mutation altering degron motif	0.7055
p.Q17E	TCGA-66-2785	LUSC	TCGA	PTSTT	DEG_SPOP_SBC_1	9:13	Mutation rewiring degron network	0.2222
p.Q17E	DO26520	LUSC	ICGC	PTSTT	DEG_SPOP_SBC_1	9:13	Mutation rewiring degron network	0.2222
p.I19V	TCGA-AX-A1CE	UCEC	TCGA	PTSTT	DEG_SPOP_SBC_1	9:13	Mutation rewiring degron network	0.1667
p.I19V	DO42280	UCEC	ICGC	PTSTT	DEG_SPOP_SBC_1	9:13	Mutation rewiring degron network	0.1667
p.M18I	TCGA-BF-AAP7	SKCM	TCGA	PTSTT	DEG_SPOP_SBC_1	9:13	Mutation rewiring degron network	0.1944
p.M18I	DO219472	SKCM	ICGC	PTSTT	DEG_SPOP_SBC_1	9:13	Mutation rewiring degron network	0.1944
p.K16N	TCGA-MI-A75I	LIHC	TCGA	PTSTT	DEG_SPOP_SBC_1	9:13	Mutation substituting flanking lysine	0.3611
p.K16N	DO49712	LIHC	ICGC	PTSTT	DEG_SPOP_SBC_1	9:13	Mutation substituting flanking lysine	0.3611
p.A2T	TCGA-VQ-A8P2	STAD	TCGA	PTSTT	DEG_SPOP_SBC_1	9:13	Mutation substituting flanking lysine	0.25
p.A2T	DO51761	STAD	ICGC	PTSTT	DEG_SPOP_SBC_1	9:13	Mutation substituting flanking lysine	0.25
p.I19T	DO222780	BTCA	ICGC	PTSTT	DEG_SPOP_SBC_1	9:13	Mutation rewiring degron network	0.1667
p.V4I	SIDM00783	Colorectal Carcinoma	GDSC	PTSTT	DEG_SPOP_SBC_1	9:13	Mutation rewiring degron network	0.1944

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons