DegronMD

Uniprot ID: Q02505

Source protein: Mucin-3A

Source gene: MUC3A

Class: DEG_SPOP_SBC_1

Location: 2860:2864

E3 ligase: SPOP

DEGRON score: 0.9693

ASA_SCORE: 98.58

COIL: 0.8928

CONS_SCORE: 0

DSS_SCORE: 0.5154

HELIX: 0.0126

FCONS_SCORE: 0

RIG_SCORE: 0.7939

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E2870D	SIDM00216	Colorectal Carcinoma	GDSC	VFTST	DEG_SPOP_SBC_1	0.1667
p.E2870D	SNU-175	large_intestine	COSMIC	VFTST	DEG_SPOP_SBC_1	0.1667
p.S2863R	SIDM00555	Glioblastoma	GDSC	VFTST	DEG_SPOP_SBC_1	0.7427
p.S2863R	KS-1	central_nervous_system	COSMIC	VFTST	DEG_SPOP_SBC_1	0.7427
p.P2856H	SIDM00927	Small Cell Lung Carcinoma	GDSC	VFTST	DEG_SPOP_SBC_1	0.2222
p.P2856H	NCI-H510A	lung	COSMIC	VFTST	DEG_SPOP_SBC_1	0.2222
p.T2871I	SIDM01133	Other Solid Cancers	GDSC	VFTST	DEG_SPOP_SBC_1	0.1389
p.V2860A	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	VFTST	DEG_SPOP_SBC_1	0.5825

DegronMD: protein-targeted degradation, mutation and drug response to degrons