DegronMD

Uniprot ID: Q02505

Source protein: Mucin-3A

Source gene: MUC3A

Class: DEG_SCF_FBW7_1

Location: 2573:2580

E3 ligase: FBXW7

DEGRON score: 0.9933

ASA_SCORE: 105.9625

COIL: 0.9654

CONS_SCORE: 0

DSS_SCORE: 0.5031

HELIX: 0.0083

FCONS_SCORE: 0

RIG_SCORE: 0.7272

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I2573L	SIDM01483	Melanoma	GDSC	IPETPTQT	DEG_SCF_FBW7_1	0.6063
p.I2573L	SIDM00768	Non-Small Cell Lung Carcinoma	GDSC	IPETPTQT	DEG_SCF_FBW7_1	0.6063
p.I2573L	COLO-741	large_intestine	COSMIC	IPETPTQT	DEG_SCF_FBW7_1	0.6063
p.I2573L	NCI-H1869	lung	COSMIC	IPETPTQT	DEG_SCF_FBW7_1	0.6063
p.I2570N	SIDM01001	Breast Carcinoma	GDSC	IPETPTQT	DEG_SCF_FBW7_1	0.25
p.S2565F	SIDM00140	Melanoma	GDSC	IPETPTQT	DEG_SCF_FBW7_1	0.1111
p.S2565F	COLO-792	skin	COSMIC	IPETPTQT	DEG_SCF_FBW7_1	0.1111

Showing 1 to 7 of 7 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02505	Mucin-3A	DEG_SCF_FBW7_1	2573:2580	IPETPTQT	FBXW7	0.9933	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons