DegronMD

Uniprot ID: Q02505

Source protein: Mucin-3A

Source gene: MUC3A

Class: DEG_SCF_FBW7_1

Location: 518:524

E3 ligase: FBXW7

DEGRON score: 0.6531

ASA_SCORE: 87.4714

COIL: 0.9081

CONS_SCORE: 0.4534

DSS_SCORE: 0.3235

HELIX: 0.0216

FCONS_SCORE: 1

RIG_SCORE: 0.7626

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G514V	TCGA-44-6778	LUAD	TCGA	LSTPTSS	DEG_SCF_FBW7_1	0.2222
p.G514V	DO25603	LUAD	ICGC	LSTPTSS	DEG_SCF_FBW7_1	0.2222
p.L525I	TCGA-55-7995	LUAD	TCGA	LSTPTSS	DEG_SCF_FBW7_1	0.3056
p.L525I	DO228813	LICA	ICGC	LSTPTSS	DEG_SCF_FBW7_1	0.3056
p.L525I	DO45323	LUAD	ICGC	LSTPTSS	DEG_SCF_FBW7_1	0.3056
p.G515V	TCGA-64-5781	LUAD	TCGA	LSTPTSS	DEG_SCF_FBW7_1	0.25
p.G515V	DO23740	LUAD	ICGC	LSTPTSS	DEG_SCF_FBW7_1	0.25
p.C511Y	TCGA-90-7964	LUSC	TCGA	LSTPTSS	DEG_SCF_FBW7_1	0.1389
p.C511Y	DO27046	LUSC	ICGC	LSTPTSS	DEG_SCF_FBW7_1	0.1389
p.Q521P	TCGA-AP-A1DV	UCEC	TCGA	LSTPTSS	DEG_SCF_FBW7_1	0.7035
p.Q521P	DO43186	UCEC	ICGC	LSTPTSS	DEG_SCF_FBW7_1	0.7035
p.D512H	TCGA-CV-7414	HNSC	TCGA	LSTPTSS	DEG_SCF_FBW7_1	0.1667
p.D512H	DO15631	HNSC	ICGC	LSTPTSS	DEG_SCF_FBW7_1	0.1667
p.G527E	TCGA-D3-A8GK	SKCM	TCGA	LSTPTSS	DEG_SCF_FBW7_1	0.25
p.G527E	TCGA-HU-A4G6	STAD	TCGA	LSTPTSS	DEG_SCF_FBW7_1	0.25
p.G527E	DO50286	SKCM	ICGC	LSTPTSS	DEG_SCF_FBW7_1	0.25
p.G527E	DO47747	STAD	ICGC	LSTPTSS	DEG_SCF_FBW7_1	0.25
p.A523V	TCGA-DF-A2KR	UCEC	TCGA	LSTPTSS	DEG_SCF_FBW7_1	0.6936
p.A523V	DO223284	UCEC	ICGC	LSTPTSS	DEG_SCF_FBW7_1	0.6936
p.L525F	TCGA-EE-A2GR	SKCM	TCGA	LSTPTSS	DEG_SCF_FBW7_1	0.3056
p.L525F	DO37996	SKCM	ICGC	LSTPTSS	DEG_SCF_FBW7_1	0.3056
p.G527V	TCGA-MN-A4N5	LUAD	TCGA	LSTPTSS	DEG_SCF_FBW7_1	0.25
p.G527V	DO45332	LUAD	ICGC	LSTPTSS	DEG_SCF_FBW7_1	0.25
p.G527V	ACH-002295	Head and Neck Cancer	CCLE	LSTPTSS	DEG_SCF_FBW7_1	0.25
p.P526S	TCGA-W3-AA1O	SKCM	TCGA	LSTPTSS	DEG_SCF_FBW7_1	0.2778
p.P526S	DO51274	SKCM	ICGC	LSTPTSS	DEG_SCF_FBW7_1	0.2778
p.W517L	DO224566	LUSC	ICGC	LSTPTSS	DEG_SCF_FBW7_1	0.3056
p.W517L	DO231007	LUSC	ICGC	LSTPTSS	DEG_SCF_FBW7_1	0.3056
p.D512A	DO220890	MELA	ICGC	LSTPTSS	DEG_SCF_FBW7_1	0.1667
p.Q521H	ACH-000401	Skin Cancer	CCLE	LSTPTSS	DEG_SCF_FBW7_1	0.7582
p.Q519H	ACH-000775	Lung Cancer	CCLE	LSTPTSS	DEG_SCF_FBW7_1	0.7582
p.Q519H	ACH-002337	Lung Cancer	CCLE	LSTPTSS	DEG_SCF_FBW7_1	0.7582
p.R532H	ACH-000940	Endometrial/Uterine Cancer	CCLE	LSTPTSS	DEG_SCF_FBW7_1	0.1111
p.R532H	ACH-001517	Endometrial/Uterine Cancer	CCLE	LSTPTSS	DEG_SCF_FBW7_1	0.1111
p.D531N	ACH-000987	Skin Cancer	CCLE	LSTPTSS	DEG_SCF_FBW7_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LSTPTSS

Degron related mutations and impact score

Drug responses associated with MUC3A mutations

All proteins holding degron of LSTPTSS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02505	Mucin-3A	DEG_SCF_FBW7_1	518:524	LSTPTSS	FBXW7	0.6531	More...