DegronMD

Uniprot ID: Q02505

Source protein: Mucin-3A

Source gene: MUC3A

Class: DEG_SPOP_SBC_1

Location: 2541:2545

E3 ligase: SPOP

DEGRON score: 0.9689

ASA_SCORE: 83.42

COIL: 0.9118

CONS_SCORE: 0

DSS_SCORE: 0.5389

HELIX: 0.0108

FCONS_SCORE: 0

RIG_SCORE: 0.6763

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T2544I	SIDM01943	Colorectal Carcinoma	GDSC	VGTTS	DEG_SPOP_SBC_1	0.7078
p.V2551L	SIDM01004	Chronic Myelogenous Leukemia	GDSC	VGTTS	DEG_SPOP_SBC_1	0.1667
p.V2551L	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	VGTTS	DEG_SPOP_SBC_1	0.1667
p.S2538L	SIDM01175	Other Sarcomas	GDSC	VGTTS	DEG_SPOP_SBC_1	0.25
p.S2538L	SW684	soft_tissue	COSMIC	VGTTS	DEG_SPOP_SBC_1	0.25
p.S2545C	SIDM00923	Cervical Carcinoma	GDSC	VGTTS	DEG_SPOP_SBC_1	0.8652
p.S2545C	Ca-Ski	cervix	COSMIC	VGTTS	DEG_SPOP_SBC_1	0.8652
p.S2534I	SIDM01178	Other Solid Cancers	GDSC	VGTTS	DEG_SPOP_SBC_1	0.1389
p.V2541E	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	VGTTS	DEG_SPOP_SBC_1	0.7693
p.V2541E	H513	pleura	COSMIC	VGTTS	DEG_SPOP_SBC_1	0.7693
p.T2544S	SIDM00875	Breast Carcinoma	GDSC	VGTTS	DEG_SPOP_SBC_1	0.6005
p.T2544S	SIDM00844	Burkitt's Lymphoma	GDSC	VGTTS	DEG_SPOP_SBC_1	0.6005

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02505	Mucin-3A	DEG_SPOP_SBC_1	2541:2545	VGTTS	SPOP	0.9689	More...
Q2TAL8	Transcriptional regulator QRICH1	DEG_SPOP_SBC_1	362:366	VGTTS	SPOP	0.9982	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	6306:6310	VGTTS	SPOP	0.9653	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10107:10111	VGTTS	SPOP	0.976	More...
Q8TF05	Serine/threonine-protein phosphatase 4 regulatory subunit 1	DEG_SPOP_SBC_1	438:442	VGTTS	SPOP	0.9657	More...
Q9H195	Mucin-3B	DEG_SPOP_SBC_1	454:458	VGTTS	SPOP	0.9836	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons