DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 10107:10111

E3 ligase: SPOP

DEGRON score: 0.976

ASA_SCORE: 76

COIL: 0.812

CONS_SCORE: 0

DSS_SCORE: 0.4822

HELIX: 0.016

FCONS_SCORE: 0

RIG_SCORE: 0.6433

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E10115Q	TCGA-E7-A6ME	BLCA	TCGA	VGTTS	DEG_SPOP_SBC_1	0.2222
p.E10115Q	DO51874	BLCA	ICGC	VGTTS	DEG_SPOP_SBC_1	0.2222
p.G10108E	TCGA-EE-A17Y	SKCM	TCGA	VGTTS	DEG_SPOP_SBC_1	0.6087
p.G10108E	TCGA-EE-A3AA	SKCM	TCGA	VGTTS	DEG_SPOP_SBC_1	0.6087
p.G10108E	DO222632	MELA	ICGC	VGTTS	DEG_SPOP_SBC_1	0.6087
p.G10108E	DO37571	SKCM	ICGC	VGTTS	DEG_SPOP_SBC_1	0.6087
p.G10108E	DO47459	SKCM	ICGC	VGTTS	DEG_SPOP_SBC_1	0.6087
p.G10108E	SIDM00190	Melanoma	GDSC	VGTTS	DEG_SPOP_SBC_1	0.6087
p.G10108E	CP66-MEL	skin	COSMIC	VGTTS	DEG_SPOP_SBC_1	0.6087
p.H10097Y	TCGA-EE-A29E	SKCM	TCGA	VGTTS	DEG_SPOP_SBC_1	0.0556
p.H10097Y	DO222644	MELA	ICGC	VGTTS	DEG_SPOP_SBC_1	0.0556
p.H10097Y	DO222753	MELA	ICGC	VGTTS	DEG_SPOP_SBC_1	0.0556
p.H10097Y	DO37831	SKCM	ICGC	VGTTS	DEG_SPOP_SBC_1	0.0556
p.H10097R	TCGA-F1-6177	STAD	TCGA	VGTTS	DEG_SPOP_SBC_1	0.0556
p.H10097R	DO38727	STAD	ICGC	VGTTS	DEG_SPOP_SBC_1	0.0556
p.T10109N	TCGA-FJ-A3ZE	BLCA	TCGA	VGTTS	DEG_SPOP_SBC_1	0.7055
p.T10109N	DO484	BLCA	ICGC	VGTTS	DEG_SPOP_SBC_1	0.7055
p.S10118F	TCGA-GN-A266	SKCM	TCGA	VGTTS	DEG_SPOP_SBC_1	0.1389
p.S10118F	DO37432	SKCM	ICGC	VGTTS	DEG_SPOP_SBC_1	0.1389
p.M10102I	TCGA-IB-A5SP	PAAD	TCGA	VGTTS	DEG_SPOP_SBC_1	0.1944
p.M10102I	DO46635	PAAD	ICGC	VGTTS	DEG_SPOP_SBC_1	0.1944
p.S10099F	DO220856	MELA	ICGC	VGTTS	DEG_SPOP_SBC_1	0.1111
p.P10098S	DO222632	MELA	ICGC	VGTTS	DEG_SPOP_SBC_1	0.0833
p.V10104M	SIDM00186	Kidney Carcinoma	GDSC	VGTTS	DEG_SPOP_SBC_1	0.25
p.V10104M	ACH-002151	Kidney Cancer	CCLE	VGTTS	DEG_SPOP_SBC_1	0.25
p.V10104M	LB2241-RCC	kidney	COSMIC	VGTTS	DEG_SPOP_SBC_1	0.25
p.Y10117H	SIDM00501	Oral Cavity Carcinoma	GDSC	VGTTS	DEG_SPOP_SBC_1	0.1667
p.Y10117H	ACH-001332	Head and Neck Cancer	CCLE	VGTTS	DEG_SPOP_SBC_1	0.1667
p.Y10117H	BICR78	upper_aerodigestive_tract	COSMIC	VGTTS	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02505	Mucin-3A	DEG_SPOP_SBC_1	2541:2545	VGTTS	SPOP	0.9689	More...
Q2TAL8	Transcriptional regulator QRICH1	DEG_SPOP_SBC_1	362:366	VGTTS	SPOP	0.9982	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	6306:6310	VGTTS	SPOP	0.9653	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10107:10111	VGTTS	SPOP	0.976	More...
Q8TF05	Serine/threonine-protein phosphatase 4 regulatory subunit 1	DEG_SPOP_SBC_1	438:442	VGTTS	SPOP	0.9657	More...
Q9H195	Mucin-3B	DEG_SPOP_SBC_1	454:458	VGTTS	SPOP	0.9836	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VGTTS

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of VGTTS