DegronMD

Uniprot ID: Q8TF05

Source protein: Serine/threonine-protein phosphatase 4 regulatory subunit 1

Source gene: PPP4R1

Class: DEG_SPOP_SBC_1

Location: 438:442

E3 ligase: SPOP

DEGRON score: 0.9657

ASA_SCORE: 69.2

COIL: 0.8836

CONS_SCORE: 0.3768

DSS_SCORE: 0.4941

HELIX: 0.0552

FCONS_SCORE: 1.0443

RIG_SCORE: 0.6771

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S432Y	TCGA-A5-A1OF	UCEC	TCGA	VGTTS	DEG_SPOP_SBC_1	0.1667
p.P436Q	TCGA-GN-A265	SKCM	TCGA	VGTTS	DEG_SPOP_SBC_1	0.2778
p.K431N	TCGA-IB-7651	PAAD	TCGA	VGTTS	DEG_SPOP_SBC_1	0.25
p.A429T	DO11854	GBM	ICGC	VGTTS	DEG_SPOP_SBC_1	0.0833
p.E434G	DO228338	MALY	ICGC	VGTTS	DEG_SPOP_SBC_1	0.2222
p.E434G	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	VGTTS	DEG_SPOP_SBC_1	0.2222
p.E451G	SIDM00948	Burkitt's Lymphoma	GDSC	VGTTS	DEG_SPOP_SBC_1	0.0833
p.E451G	ACH-002232	Lymphoma	CCLE	VGTTS	DEG_SPOP_SBC_1	0.0833
p.E451G	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	VGTTS	DEG_SPOP_SBC_1	0.0833
p.L446R	BT-20	breast	COSMIC	VGTTS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02505	Mucin-3A	DEG_SPOP_SBC_1	2541:2545	VGTTS	SPOP	0.9689	More...
Q2TAL8	Transcriptional regulator QRICH1	DEG_SPOP_SBC_1	362:366	VGTTS	SPOP	0.9982	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	6306:6310	VGTTS	SPOP	0.9653	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10107:10111	VGTTS	SPOP	0.976	More...
Q8TF05	Serine/threonine-protein phosphatase 4 regulatory subunit 1	DEG_SPOP_SBC_1	438:442	VGTTS	SPOP	0.9657	More...
Q9H195	Mucin-3B	DEG_SPOP_SBC_1	454:458	VGTTS	SPOP	0.9836	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons