DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 6306:6310

E3 ligase: SPOP

DEGRON score: 0.9653

ASA_SCORE: 75.44

COIL: 0.8022

CONS_SCORE: 0

DSS_SCORE: 0.3708

HELIX: 0.0102

FCONS_SCORE: 0

RIG_SCORE: 0.6891

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P6297H	TCGA-06-5416	GBM	TCGA	VGTTS	DEG_SPOP_SBC_1	0.0833
p.P6297H	DO10880	GBM	ICGC	VGTTS	DEG_SPOP_SBC_1	0.0833
p.A6302E	TCGA-AG-A011	READ	TCGA	VGTTS	DEG_SPOP_SBC_1	0.2222
p.H6296Q	TCGA-BB-7870	HNSC	TCGA	VGTTS	DEG_SPOP_SBC_1	0.0556
p.H6296Q	DO14378	HNSC	ICGC	VGTTS	DEG_SPOP_SBC_1	0.0556
p.E6314K	TCGA-D3-A8GL	SKCM	TCGA	VGTTS	DEG_SPOP_SBC_1	0.2222
p.E6314K	TCGA-EE-A2MR	SKCM	TCGA	VGTTS	DEG_SPOP_SBC_1	0.2222
p.E6314K	TCGA-FS-A1ZK	SKCM	TCGA	VGTTS	DEG_SPOP_SBC_1	0.2222
p.E6314K	TCGA-W3-AA1V	SKCM	TCGA	VGTTS	DEG_SPOP_SBC_1	0.2222
p.E6314K	DO37819	SKCM	ICGC	VGTTS	DEG_SPOP_SBC_1	0.2222
p.E6314K	DO37474	SKCM	ICGC	VGTTS	DEG_SPOP_SBC_1	0.2222
p.E6314K	DO50287	SKCM	ICGC	VGTTS	DEG_SPOP_SBC_1	0.2222
p.E6314K	DO51276	SKCM	ICGC	VGTTS	DEG_SPOP_SBC_1	0.2222
p.Y6316C	TCGA-MV-A51V	BLCA	TCGA	VGTTS	DEG_SPOP_SBC_1	0.1667
p.Y6316C	DO474	BLCA	ICGC	VGTTS	DEG_SPOP_SBC_1	0.1667
p.V6306M	DO227709	COCA	ICGC	VGTTS	DEG_SPOP_SBC_1	0.7208
p.V6306M	DO227999	COCA	ICGC	VGTTS	DEG_SPOP_SBC_1	0.7208
p.V6306M	DO229003	COCA	ICGC	VGTTS	DEG_SPOP_SBC_1	0.7208
p.V6306M	DO229489	LAML	ICGC	VGTTS	DEG_SPOP_SBC_1	0.7208
p.V6306M	DO229505	LAML	ICGC	VGTTS	DEG_SPOP_SBC_1	0.7208
p.V6306M	DO23166	LINC	ICGC	VGTTS	DEG_SPOP_SBC_1	0.7208
p.V6306M	DO231056	LUSC	ICGC	VGTTS	DEG_SPOP_SBC_1	0.7208
p.T6301R	DO50885	LICA	ICGC	VGTTS	DEG_SPOP_SBC_1	0.1944
p.P6312L	SIDM00086	Kidney Carcinoma	GDSC	VGTTS	DEG_SPOP_SBC_1	0.2778
p.P6312L	ACH-002195	Kidney Cancer	CCLE	VGTTS	DEG_SPOP_SBC_1	0.2778
p.P6312L	RXF393	kidney	COSMIC	VGTTS	DEG_SPOP_SBC_1	0.2778
p.F6315L	SIDM00193	Colorectal Carcinoma	GDSC	VGTTS	DEG_SPOP_SBC_1	0.1944
p.F6315L	SIDM01503	Small Cell Lung Carcinoma	GDSC	VGTTS	DEG_SPOP_SBC_1	0.1944
p.F6315L	ACH-000844	Lung Cancer	CCLE	VGTTS	DEG_SPOP_SBC_1	0.1944
p.F6315L	ACH-000991	Colon/Colorectal Cancer	CCLE	VGTTS	DEG_SPOP_SBC_1	0.1944
p.F6315L	SNU-81	large_intestine	COSMIC	VGTTS	DEG_SPOP_SBC_1	0.1944
p.E6314G	ACH-001132	Lymphoma	CCLE	VGTTS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02505	Mucin-3A	DEG_SPOP_SBC_1	2541:2545	VGTTS	SPOP	0.9689	More...
Q2TAL8	Transcriptional regulator QRICH1	DEG_SPOP_SBC_1	362:366	VGTTS	SPOP	0.9982	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	6306:6310	VGTTS	SPOP	0.9653	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10107:10111	VGTTS	SPOP	0.976	More...
Q8TF05	Serine/threonine-protein phosphatase 4 regulatory subunit 1	DEG_SPOP_SBC_1	438:442	VGTTS	SPOP	0.9657	More...
Q9H195	Mucin-3B	DEG_SPOP_SBC_1	454:458	VGTTS	SPOP	0.9836	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VGTTS

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of VGTTS