DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
VGTTS
Uniprot ID:
Q9H195
Source protein:
Mucin-3B
Source gene:
MUC3B
Class:
DEG_SPOP_SBC_1
Location:
454:458
E3 ligase:
SPOP
DEGRON score:
0.9836
ASA_SCORE:
83.78
COIL:
0.9514
CONS_SCORE:
0.4065
DSS_SCORE:
0.5444
HELIX:
0.0124
FCONS_SCORE:
0.9813
RIG_SCORE:
0.6645
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with MUC3B mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VGTTS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q02505
Mucin-3A
DEG_SPOP_SBC_1
2541:2545
VGTTS
SPOP
0.9689
More...
Q2TAL8
Transcriptional regulator QRICH1
DEG_SPOP_SBC_1
362:366
VGTTS
SPOP
0.9982
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
6306:6310
VGTTS
SPOP
0.9653
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
10107:10111
VGTTS
SPOP
0.976
More...
Q8TF05
Serine/threonine-protein phosphatase 4 regulatory subunit 1
DEG_SPOP_SBC_1
438:442
VGTTS
SPOP
0.9657
More...
Q9H195
Mucin-3B
DEG_SPOP_SBC_1
454:458
VGTTS
SPOP
0.9836
More...