DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
VGTTS
Uniprot ID:
Q9H195
Source protein:
Mucin-3B
Source gene:
MUC3B
Class:
DEG_SPOP_SBC_1
Location:
454:458
E3 ligase:
SPOP
DEGRON score:
0.9836
ASA_SCORE:
83.78
COIL:
0.9514
CONS_SCORE:
0.4065
DSS_SCORE:
0.5444
HELIX:
0.0124
FCONS_SCORE:
0.9813
RIG_SCORE:
0.6645
Degron related mutations and impact score
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Mutation
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Degron
Degron class
Impact score
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Drug responses associated with MUC3B mutations
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Cancer
Mutation (In Degron?)
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Drug
IC50
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All proteins holding degron of VGTTS
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
6306:6310
VGTTS
SPOP
0.9653
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
10107:10111
VGTTS
SPOP
0.976
More...
Q02505
Mucin-3A
DEG_SPOP_SBC_1
2541:2545
VGTTS
SPOP
0.9689
More...
Q9H195
Mucin-3B
DEG_SPOP_SBC_1
454:458
VGTTS
SPOP
0.9836
More...
Q8TF05
Serine/threonine-protein phosphatase 4 regulatory subunit 1
DEG_SPOP_SBC_1
438:442
VGTTS
SPOP
0.9657
More...
Q2TAL8
Transcriptional regulator QRICH1
DEG_SPOP_SBC_1
362:366
VGTTS
SPOP
0.9982
More...
Showing 1 to 6 of 6 entries
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