DegronMD

Uniprot ID: Q2TAL8

Source protein: Transcriptional regulator QRICH1

Source gene: QRICH1

Class: DEG_SPOP_SBC_1

Location: 362:366

E3 ligase: SPOP

DEGRON score: 0.9982

ASA_SCORE: 78.6

COIL: 0.837

CONS_SCORE: 0.4512

DSS_SCORE: 0.4833

HELIX: 0.1296

FCONS_SCORE: 0.8724

RIG_SCORE: 0.7488

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K353T	TCGA-EO-A3B0	UCEC	TCGA	VGTTS	DEG_SPOP_SBC_1	0.1944
p.K353T	DO219773	UCEC	ICGC	VGTTS	DEG_SPOP_SBC_1	0.1944
p.K369E	DO222884	COCA	ICGC	VGTTS	DEG_SPOP_SBC_1	0.3611

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02505	Mucin-3A	DEG_SPOP_SBC_1	2541:2545	VGTTS	SPOP	0.9689	More...
Q2TAL8	Transcriptional regulator QRICH1	DEG_SPOP_SBC_1	362:366	VGTTS	SPOP	0.9982	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	6306:6310	VGTTS	SPOP	0.9653	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10107:10111	VGTTS	SPOP	0.976	More...
Q8TF05	Serine/threonine-protein phosphatase 4 regulatory subunit 1	DEG_SPOP_SBC_1	438:442	VGTTS	SPOP	0.9657	More...
Q9H195	Mucin-3B	DEG_SPOP_SBC_1	454:458	VGTTS	SPOP	0.9836	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons