DegronMD - Q8TF05(PPP4R1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N513T	TCGA-49-AARN	LUAD	TCGA	TRKELEEMI	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.2778
p.N513T	TCGA-49-AARN	LUAD	TCGA	LEPHID	LIG_APCC_ABBA_1	514:519	Mutation rewiring degron network	0.3056
p.P494S	TCGA-78-7539	LUAD	TCGA	TRKELEEMI	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.0833
p.S432Y	TCGA-A5-A1OF	UCEC	TCGA	VGTTS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.1667
p.K524E	TCGA-D1-A174	UCEC	TCGA	LEPHID	LIG_APCC_ABBA_1	514:519	Mutation substituting flanking lysine	0.3056
p.P436Q	TCGA-GN-A265	SKCM	TCGA	VGTTS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.2778
p.K431N	TCGA-IB-7651	PAAD	TCGA	VGTTS	DEG_SPOP_SBC_1	438:442	Mutation substituting flanking lysine	0.25
p.I453V	DO234205	ESAD	ICGC	WRTPLPEID	DEG_APCC_DBOX_1	459:467	Mutation blocking phosphorylation signal	0.6111
p.I453V	DO234285	ESAD	ICGC	WRTPLPEID	DEG_APCC_DBOX_1	459:467	Mutation blocking phosphorylation signal	0.6111
p.A515V	DO233864	GACA	ICGC	LEPHID	LIG_APCC_ABBA_1	514:519	Mutation altering degron motif	0.6936
p.A429T	DO11854	GBM	ICGC	VGTTS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.0833
p.A516T	DO21571	LAML	ICGC	LEPHID	LIG_APCC_ABBA_1	514:519	Mutation altering degron motif	0.7139
p.S521R	DO229019	LICA	ICGC	TRKELEEMI	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.0556
p.S521R	DO229019	LICA	ICGC	LEPHID	LIG_APCC_ABBA_1	514:519	Mutation rewiring degron network	0.2778
p.S464R	DO229045	LICA	ICGC	WRTPLPEID	DEG_APCC_DBOX_1	459:467	Mutation altering degron motif	0.7427
p.N496T	DO218923	LUAD	ICGC	TRKELEEMI	DEG_APCC_DBOX_1	503:511	Mutation blocking phosphorylation signal	0.5833
p.P477S	DO26210	LUAD	ICGC	WRTPLPEID	DEG_APCC_DBOX_1	459:467	Mutation rewiring degron network	0.0556
p.E434G	DO228338	MALY	ICGC	VGTTS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.2222
p.E434G	DG-75	haematopoietic and lymphoid tissue	COSMIC	VGTTS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.2222
p.R518H	DO38427	STAD	ICGC	LEPHID	LIG_APCC_ABBA_1	514:519	Mutation altering degron motif	0.8244
p.R518H	DO43891	UCEC	ICGC	LEPHID	LIG_APCC_ABBA_1	514:519	Mutation altering degron motif	0.8244
p.E498D	DO229224	THCA	ICGC	TRKELEEMI	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.1944
p.K507E	DO40900	UCEC	ICGC	TRKELEEMI	DEG_APCC_DBOX_1	503:511	Mutation altering degron motif	0.7022
p.V523I	SIDM00985	Burkitt's Lymphoma	GDSC	LEPHID	LIG_APCC_ABBA_1	514:519	Mutation rewiring degron network	0.2222
p.V523I	SIDM00799	Glioblastoma	GDSC	LEPHID	LIG_APCC_ABBA_1	514:519	Mutation rewiring degron network	0.2222
p.H457Y	SIDM00336	Melanoma	GDSC	WRTPLPEID	DEG_APCC_DBOX_1	459:467	Mutation rewiring degron network	0.2778
p.H457Y	ACH-000881	Skin Cancer	CCLE	WRTPLPEID	DEG_APCC_DBOX_1	459:467	Mutation rewiring degron network	0.2778
p.E451G	SIDM00948	Burkitt's Lymphoma	GDSC	WRTPLPEID	DEG_APCC_DBOX_1	459:467	Mutation rewiring degron network	0.1111
p.E451G	SIDM00948	Burkitt's Lymphoma	GDSC	VGTTS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.0833
p.E451G	ACH-002232	Lymphoma	CCLE	WRTPLPEID	DEG_APCC_DBOX_1	459:467	Mutation rewiring degron network	0.1111
p.E451G	ACH-002232	Lymphoma	CCLE	VGTTS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.0833
p.E451G	DG-75	haematopoietic and lymphoid tissue	COSMIC	WRTPLPEID	DEG_APCC_DBOX_1	459:467	Mutation rewiring degron network	0.1111
p.E451G	DG-75	haematopoietic and lymphoid tissue	COSMIC	VGTTS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.0833
p.L463R	SIDM00893	Breast Carcinoma	GDSC	WRTPLPEID	DEG_APCC_DBOX_1	459:467	Mutation altering degron motif	0.8428
p.L463R	ACH-000536	Breast Cancer	CCLE	WRTPLPEID	DEG_APCC_DBOX_1	459:467	Mutation altering degron motif	0.8428
p.L463R	BT-20	breast	COSMIC	WRTPLPEID	DEG_APCC_DBOX_1	459:467	Mutation altering degron motif	0.8428
p.L468V	SIDM01322	Oral Cavity Carcinoma	GDSC	WRTPLPEID	DEG_APCC_DBOX_1	459:467	Mutation rewiring degron network	0.3056
p.L468V	ACH-000735	Head and Neck Cancer	CCLE	WRTPLPEID	DEG_APCC_DBOX_1	459:467	Mutation rewiring degron network	0.3056
p.L446R	BT-20	breast	COSMIC	VGTTS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PPP4R1

UniProt ID: Q8TF05

Entrez ID: 9989

Protein name: Serine/threonine-protein phosphatase 4 regulatory subunit 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PPP4R1 in