DegronMD

Uniprot ID: Q8TF05

Source protein: Serine/threonine-protein phosphatase 4 regulatory subunit 1

Source gene: PPP4R1

Class: DEG_APCC_DBOX_1

Location: 503:511

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5356

ASA_SCORE: 76.1667

COIL: 0.093

CONS_SCORE: 0.3723

DSS_SCORE: 0.6121

HELIX: 0.9078

FCONS_SCORE: 0.986

RIG_SCORE: 0.7602

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N513T	TCGA-49-AARN	LUAD	TCGA	TRKELEEMI	DEG_APCC_DBOX_1	0.2778
p.P494S	TCGA-78-7539	LUAD	TCGA	TRKELEEMI	DEG_APCC_DBOX_1	0.0833
p.S521R	DO229019	LICA	ICGC	TRKELEEMI	DEG_APCC_DBOX_1	0.0556
p.N496T	DO218923	LUAD	ICGC	TRKELEEMI	DEG_APCC_DBOX_1	0.5833
p.E498D	DO229224	THCA	ICGC	TRKELEEMI	DEG_APCC_DBOX_1	0.1944
p.K507E	DO40900	UCEC	ICGC	TRKELEEMI	DEG_APCC_DBOX_1	0.7022

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TF05	Serine/threonine-protein phosphatase 4 regulatory subunit 1	DEG_APCC_DBOX_1	503:511	TRKELEEMI	APC,CDC20,FZR1	0.5356	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons