DegronMD

Uniprot ID: Q8TF05

Source protein: Serine/threonine-protein phosphatase 4 regulatory subunit 1

Source gene: PPP4R1

Class: LIG_APCC_ABBA_1

Location: 514:519

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8747

ASA_SCORE: 83.3667

COIL: 0.7892

CONS_SCORE: 0.4156

DSS_SCORE: 0.5492

HELIX: 0.1853

FCONS_SCORE: 1.099

RIG_SCORE: 0.7379

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N513T	TCGA-49-AARN	LUAD	TCGA	LEPHID	LIG_APCC_ABBA_1	0.3056
p.K524E	TCGA-D1-A174	UCEC	TCGA	LEPHID	LIG_APCC_ABBA_1	0.3056
p.A515V	DO233864	GACA	ICGC	LEPHID	LIG_APCC_ABBA_1	0.6936
p.A516T	DO21571	LAML	ICGC	LEPHID	LIG_APCC_ABBA_1	0.7139
p.S521R	DO229019	LICA	ICGC	LEPHID	LIG_APCC_ABBA_1	0.2778
p.R518H	DO38427	STAD	ICGC	LEPHID	LIG_APCC_ABBA_1	0.8244
p.R518H	DO43891	UCEC	ICGC	LEPHID	LIG_APCC_ABBA_1	0.8244
p.V523I	SIDM00985	Burkitt's Lymphoma	GDSC	LEPHID	LIG_APCC_ABBA_1	0.2222
p.V523I	SIDM00799	Glioblastoma	GDSC	LEPHID	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TF05	Serine/threonine-protein phosphatase 4 regulatory subunit 1	LIG_APCC_ABBA_1	514:519	LEPHID	APC,CDC20,FZR1	0.8747	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons