DegronMD

Uniprot ID: Q8TF05

Source protein: Serine/threonine-protein phosphatase 4 regulatory subunit 1

Source gene: PPP4R1

Class: DEG_APCC_DBOX_1

Location: 459:467

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9988

ASA_SCORE: 74.9889

COIL: 0.7477

CONS_SCORE: 0.4099

DSS_SCORE: 0.3838

HELIX: 0.1248

FCONS_SCORE: 1.1273

RIG_SCORE: 0.8084

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I453V	DO234205	ESAD	ICGC	WRTPLPEID	DEG_APCC_DBOX_1	0.6111
p.I453V	DO234285	ESAD	ICGC	WRTPLPEID	DEG_APCC_DBOX_1	0.6111
p.S464R	DO229045	LICA	ICGC	WRTPLPEID	DEG_APCC_DBOX_1	0.7427
p.P477S	DO26210	LUAD	ICGC	WRTPLPEID	DEG_APCC_DBOX_1	0.0556
p.H457Y	SIDM00336	Melanoma	GDSC	WRTPLPEID	DEG_APCC_DBOX_1	0.2778
p.H457Y	ACH-000881	Skin Cancer	CCLE	WRTPLPEID	DEG_APCC_DBOX_1	0.2778
p.E451G	SIDM00948	Burkitt's Lymphoma	GDSC	WRTPLPEID	DEG_APCC_DBOX_1	0.1111
p.E451G	ACH-002232	Lymphoma	CCLE	WRTPLPEID	DEG_APCC_DBOX_1	0.1111
p.E451G	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	WRTPLPEID	DEG_APCC_DBOX_1	0.1111
p.L463R	SIDM00893	Breast Carcinoma	GDSC	WRTPLPEID	DEG_APCC_DBOX_1	0.8428
p.L463R	ACH-000536	Breast Cancer	CCLE	WRTPLPEID	DEG_APCC_DBOX_1	0.8428
p.L463R	BT-20	breast	COSMIC	WRTPLPEID	DEG_APCC_DBOX_1	0.8428
p.L468V	SIDM01322	Oral Cavity Carcinoma	GDSC	WRTPLPEID	DEG_APCC_DBOX_1	0.3056
p.L468V	ACH-000735	Head and Neck Cancer	CCLE	WRTPLPEID	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TF05	Serine/threonine-protein phosphatase 4 regulatory subunit 1	DEG_APCC_DBOX_1	459:467	WRTPLPEID	APC,CDC20,FZR1	0.9988	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons