DegronMD

Uniprot ID: Q02505

Source protein: Mucin-3A

Source gene: MUC3A

Class: DEG_SPOP_SBC_1

Location: 388:392

E3 ligase: SPOP

DEGRON score: 0.8483

ASA_SCORE: 93.26

COIL: 0.8952

CONS_SCORE: 0.4534

DSS_SCORE: 0.5703

HELIX: 0.0138

FCONS_SCORE: 1

RIG_SCORE: 0.8014

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T379I	TCGA-22-5472	LUSC	TCGA	VTTTT	DEG_SPOP_SBC_1	0.0833
p.T379I	DO27421	LUSC	ICGC	VTTTT	DEG_SPOP_SBC_1	0.0833
p.S385Y	TCGA-B5-A1MR	UCEC	TCGA	VTTTT	DEG_SPOP_SBC_1	0.25
p.S385Y	DO41758	UCEC	ICGC	VTTTT	DEG_SPOP_SBC_1	0.25
p.M387I	TCGA-BF-AAP0	SKCM	TCGA	VTTTT	DEG_SPOP_SBC_1	0.3056
p.M387I	DO219462	SKCM	ICGC	VTTTT	DEG_SPOP_SBC_1	0.3056
p.Y381F	TCGA-EO-A22X	UCEC	TCGA	VTTTT	DEG_SPOP_SBC_1	0.1389
p.Y381F	DO43907	UCEC	ICGC	VTTTT	DEG_SPOP_SBC_1	0.1389
p.M382I	TCGA-W3-AA1V	SKCM	TCGA	VTTTT	DEG_SPOP_SBC_1	0.1667
p.M382I	DO51276	SKCM	ICGC	VTTTT	DEG_SPOP_SBC_1	0.1667
p.S396T	DO224674	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.2222
p.S396T	DO224639	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.2222
p.S396T	DO222748	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.2222
p.S396T	DO229010	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.2222
p.S396T	DO229013	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.2222
p.S396T	DO229016	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.2222
p.S396T	DO229003	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.2222
p.S396T	DO229005	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.2222
p.S396T	DO229006	LICA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.2222
p.S396T	DO229148	THCA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.2222
p.S396T	DO229272	THCA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.2222
p.S396T	DO229084	THCA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.2222
p.S396L	DO224674	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.2222
p.S396L	DO222748	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.2222
p.S396L	DO229010	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.2222
p.S396L	DO229013	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.2222
p.S396L	DO229016	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.2222
p.S396L	DO229003	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.2222
p.S396L	DO229005	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.2222
p.S396L	DO229006	LICA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.2222
p.S396L	DO229148	THCA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.2222
p.S396L	DO229272	THCA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.2222
p.S396L	DO229085	THCA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.2222
p.S396L	DO229084	THCA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.2222
p.M388T	DO224674	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.7423
p.M388T	DO229010	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.7423
p.M388T	DO229013	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.7423
p.M388T	DO229016	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.7423
p.M388T	DO229003	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.7423
p.M388T	DO229005	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.7423
p.M388T	DO50991	LAML	ICGC	VTTTT	DEG_SPOP_SBC_1	0.7423
p.M388T	DO51000	LAML	ICGC	VTTTT	DEG_SPOP_SBC_1	0.7423
p.M388T	DO229024	LICA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.7423
p.Y381H	DO229010	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.1389
p.Y381H	DO229013	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.1389
p.Y381H	DO229016	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.1389
p.Y381H	DO229003	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.1389
p.Y381H	DO229005	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.1389
p.Y381H	DO50991	LAML	ICGC	VTTTT	DEG_SPOP_SBC_1	0.1389
p.Y381H	DO51025	LAML	ICGC	VTTTT	DEG_SPOP_SBC_1	0.1389
p.Y381H	DO51011	LAML	ICGC	VTTTT	DEG_SPOP_SBC_1	0.1389
p.Y381H	DO229024	LICA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.1389
p.T379A	DO229010	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.0833
p.T379A	DO229013	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.0833
p.T379A	DO229016	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.0833
p.T379A	DO229003	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.0833
p.T379A	DO229005	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.0833
p.T379A	DO50991	LAML	ICGC	VTTTT	DEG_SPOP_SBC_1	0.0833
p.T379A	DO51025	LAML	ICGC	VTTTT	DEG_SPOP_SBC_1	0.0833
p.T379A	DO51011	LAML	ICGC	VTTTT	DEG_SPOP_SBC_1	0.0833
p.T379A	DO51012	LAML	ICGC	VTTTT	DEG_SPOP_SBC_1	0.0833
p.T379A	DO229024	LICA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.0833
p.M382V	DO51965	PRAD	ICGC	VTTTT	DEG_SPOP_SBC_1	0.1667
p.T381K	SIDM00555	Glioblastoma	GDSC	VTTTT	DEG_SPOP_SBC_1	0.1389
p.T381K	SIDM00530	Esophageal Carcinoma	GDSC	VTTTT	DEG_SPOP_SBC_1	0.1389
p.T381K	SIDM00301	Pancreatic Carcinoma	GDSC	VTTTT	DEG_SPOP_SBC_1	0.1389
p.T381K	SIDM01695	Acute Myeloid Leukemia	GDSC	VTTTT	DEG_SPOP_SBC_1	0.1389
p.S395F	SIDM00971	Breast Carcinoma	GDSC	VTTTT	DEG_SPOP_SBC_1	0.25
p.S395F	ZR-75-30	breast	COSMIC	VTTTT	DEG_SPOP_SBC_1	0.25
p.P400S	SIDM00892	Breast Carcinoma	GDSC	VTTTT	DEG_SPOP_SBC_1	0.1111
p.P400S	BT-483	breast	COSMIC	VTTTT	DEG_SPOP_SBC_1	0.1111
p.L387S	SIDM00217	Colorectal Carcinoma	GDSC	VTTTT	DEG_SPOP_SBC_1	0.3056
p.L387S	SNU-1040	large_intestine	COSMIC	VTTTT	DEG_SPOP_SBC_1	0.3056
p.S402F	ACH-000884	Skin Cancer	CCLE	VTTTT	DEG_SPOP_SBC_1	0.0556
p.S402F	ACH-002159	Skin Cancer	CCLE	VTTTT	DEG_SPOP_SBC_1	0.0556
p.M388I	ACH-000979	Prostate Cancer	CCLE	VTTTT	DEG_SPOP_SBC_1	0.7618
p.P397L	ACH-001654	Esophageal Cancer	CCLE	VTTTT	DEG_SPOP_SBC_1	0.1944
p.M387V	ACH-002135	Lung Cancer	CCLE	VTTTT	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14490	Disks large-associated protein 1	DEG_SPOP_SBC_1	625:629	VTTTT	SPOP	0.9294	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	388:392	VTTTT	SPOP	0.8483	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	763:767	VTTTT	SPOP	0.7448	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1516:1520	VTTTT	SPOP	0.7066	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1893:1897	VTTTT	SPOP	0.6112	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	1751:1755	VTTTT	SPOP	0.9422	More...
Q12955	Ankyrin-3	DEG_SPOP_SBC_1	3959:3963	VTTTT	SPOP	0.9114	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	6984:6988	VTTTT	SPOP	0.9363	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7102:7106	VTTTT	SPOP	0.7934	More...
Q8TCZ2	CD99 antigen-like protein 2	DEG_SPOP_SBC_1	98:102	VTTTT	SPOP	0.9976	More...
Q9P265	Disco-interacting protein 2 homolog B	DEG_SPOP_SBC_1	222:226	VTTTT	SPOP	0.9648	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VTTTT

Degron related mutations and impact score

Drug responses associated with MUC3A mutations

All proteins holding degron of VTTTT