DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
VTTTT
Uniprot ID:
Q02505
Source protein:
Mucin-3A
Source gene:
MUC3A
Class:
DEG_SPOP_SBC_1
Location:
1893:1897
E3 ligase:
SPOP
DEGRON score:
0.6112
ASA_SCORE:
93.98
COIL:
0.8872
CONS_SCORE:
0.6764
DSS_SCORE:
0.4515
HELIX:
0.0142
FCONS_SCORE:
0.9907
RIG_SCORE:
0.8267
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T1895M
SIDM00193
Colorectal Carcinoma
GDSC
VTTTT
DEG_SPOP_SBC_1
0.7423
p.P1888L
SIDM01004
Chronic Myelogenous Leukemia
GDSC
VTTTT
DEG_SPOP_SBC_1
0.1944
p.H1902R
SIDM01591
Breast Carcinoma
GDSC
VTTTT
DEG_SPOP_SBC_1
0.1944
Showing 1 to 3 of 3 entries
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Drug responses associated with MUC3A mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
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All proteins holding degron of VTTTT
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q12955
Ankyrin-3
DEG_SPOP_SBC_1
3959:3963
VTTTT
SPOP
0.9114
More...
Q8TCZ2
CD99 antigen-like protein 2
DEG_SPOP_SBC_1
98:102
VTTTT
SPOP
0.9976
More...
Q9P265
Disco-interacting protein 2 homolog B
DEG_SPOP_SBC_1
222:226
VTTTT
SPOP
0.9648
More...
O14490
Disks large-associated protein 1
DEG_SPOP_SBC_1
625:629
VTTTT
SPOP
0.9294
More...
Q7Z5P9
Mucin-19
DEG_SPOP_SBC_1
6984:6988
VTTTT
SPOP
0.9363
More...
Q7Z5P9
Mucin-19
DEG_SPOP_SBC_1
7102:7106
VTTTT
SPOP
0.7934
More...
Q02505
Mucin-3A
DEG_SPOP_SBC_1
388:392
VTTTT
SPOP
0.8483
More...
Q02505
Mucin-3A
DEG_SPOP_SBC_1
763:767
VTTTT
SPOP
0.7448
More...
Q02505
Mucin-3A
DEG_SPOP_SBC_1
1516:1520
VTTTT
SPOP
0.7066
More...
Q02505
Mucin-3A
DEG_SPOP_SBC_1
1893:1897
VTTTT
SPOP
0.6112
More...
Q12830
Nucleosome-remodeling factor subunit BPTF
DEG_SPOP_SBC_1
1751:1755
VTTTT
SPOP
0.9422
More...
Showing 1 to 11 of 11 entries
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