DegronMD

Uniprot ID: Q02505

Source protein: Mucin-3A

Source gene: MUC3A

Class: DEG_SCF_FBW7_1

Location: 293:300

E3 ligase: FBXW7

DEGRON score: 0.6605

ASA_SCORE: 93.425

COIL: 0.9344

CONS_SCORE: 0.4534

DSS_SCORE: 0.4781

HELIX: 0.0136

FCONS_SCORE: 1

RIG_SCORE: 0.7475

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L305I	TCGA-13-0890	OV	TCGA	LSSTPVLS	DEG_SCF_FBW7_1	0.1944
p.L305I	DO28273	OV	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.1944
p.L286V	TCGA-63-5131	LUSC	TCGA	LSSTPVLS	DEG_SCF_FBW7_1	0.1389
p.L286V	DO26898	LUSC	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.1389
p.T294N	TCGA-DF-A2KU	UCEC	TCGA	LSSTPVLS	DEG_SCF_FBW7_1	0.7055
p.T294N	DO223286	UCEC	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.7055
p.P310L	TCGA-EE-A2MD	SKCM	TCGA	LSSTPVLS	DEG_SCF_FBW7_1	0.0556
p.P310L	DO222434	MELA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.0556
p.P310L	DO37851	SKCM	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.0556
p.P284L	TCGA-EE-A2MP	SKCM	TCGA	LSSTPVLS	DEG_SCF_FBW7_1	0.0833
p.P284L	DO37818	SKCM	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.0833
p.A304T	TCGA-FI-A2D5	UCEC	TCGA	LSSTPVLS	DEG_SCF_FBW7_1	0.2222
p.A304T	DO41331	UCEC	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.2222
p.T297S	TCGA-RP-A695	SKCM	TCGA	LSSTPVLS	DEG_SCF_FBW7_1	0.7116
p.T297S	DO51270	SKCM	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.7116
p.S295C	DO224768	BRCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.643
p.S300P	DO227709	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.6752
p.T303A	DO224616	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.25
p.T303A	DO224739	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.25
p.T303A	DO229010	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.25
p.T303A	DO229013	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.25
p.T303A	DO229016	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.25
p.T303A	DO229003	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.25
p.A304G	DO224801	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.2222
p.G307R	DO222485	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.1389
p.G307R	DO229010	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.1389
p.G307R	DO229013	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.1389
p.G307R	DO229016	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.1389
p.G307R	DO229003	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.1389
p.G307R	DO229005	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.1389
p.G307D	DO222485	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.1389
p.G307D	DO229010	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.1389
p.G307D	DO229013	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.1389
p.G307D	DO229016	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.1389
p.G307D	DO229003	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.1389
p.G307D	DO229005	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.1389
p.R290S	DO222553	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.25
p.R290S	DO222840	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.25
p.R290S	DO229013	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.25
p.R290S	DO229016	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.25
p.R290S	DO229003	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.25
p.R290S	DO229005	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.25
p.P288L	DO222553	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.1944
p.P288L	DO229013	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.1944
p.P288L	DO229016	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.1944
p.P288L	DO229003	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.1944
p.P288L	DO229005	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.1944
p.T289I	DO222840	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.2222
p.T289I	DO229005	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.2222
p.T291N	DO222840	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.2778
p.T291N	DO229005	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.2778
p.L299P	DO229010	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.6471
p.L299P	DO229013	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.6471
p.L299P	DO229016	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.6471
p.L299P	DO229003	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.6471
p.L299P	DO229005	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.6471
p.L299P	DO46897	RECA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.6471
p.A290S	DO229010	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.25
p.A290S	DO229013	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.25
p.A290S	DO229016	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.25
p.A290S	DO229003	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.25
p.A290S	DO229005	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.25
p.A290S	DO229024	LICA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.25
p.I304T	DO229010	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.2222
p.I304T	DO229013	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.2222
p.I304T	DO229016	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.2222
p.I304T	DO229005	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.2222
p.N310T	DO229010	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.0556
p.N310T	DO229013	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.0556
p.N310T	DO229003	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.0556
p.V298A	DO229010	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.5825
p.V298A	DO229003	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.5825
p.S296P	DO229010	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.6752
p.S296P	DO229013	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.6752
p.S296P	DO229016	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.6752
p.S296P	DO229003	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.6752
p.S296P	DO229005	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.6752
p.S296P	DO229024	LICA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.6752
p.S300N	DO229010	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.7069
p.S300N	DO229003	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.7069
p.I308T	DO229010	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.1111
p.I308T	DO229013	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.1111
p.I308T	DO229016	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.1111
p.I308T	DO229003	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.1111
p.I308T	DO229005	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.1111
p.T303I	DO229010	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.25
p.T303I	DO229013	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.25
p.T303I	DO229016	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.25
p.T303I	DO229003	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.25
p.T303I	DO229005	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.25
p.T291S	DO229003	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.2778
p.N310D	DO229005	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.0556
p.S285C	DO234202	ESAD	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.1111
p.R290M	DO229036	LICA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.25
p.P284S	DO222868	MELA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	0.0833
p.S294C	SIDM00287	B-Lymphoblastic Leukemia	GDSC	LSSTPVLS	DEG_SCF_FBW7_1	0.643
p.S294C	BALL-1	haematopoietic_and_lymphoid_tissue	COSMIC	LSSTPVLS	DEG_SCF_FBW7_1	0.643
p.L305F	ACH-001543	Head and Neck Cancer	CCLE	LSSTPVLS	DEG_SCF_FBW7_1	0.1944
p.T301P	Saos-2	bone	COSMIC	LSSTPVLS	DEG_SCF_FBW7_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LSSTPVLS

Degron related mutations and impact score

Drug responses associated with MUC3A mutations

All proteins holding degron of LSSTPVLS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02505	Mucin-3A	DEG_SCF_FBW7_1	293:300	LSSTPVLS	FBXW7	0.6605	More...