DegronMD

Uniprot ID: O14490

Source protein: Disks large-associated protein 1

Source gene: DLGAP1

Class: DEG_SCF_TRCP1_1

Location: 355:361

E3 ligase: BTRC

DEGRON score: 0.6533

ASA_SCORE: 83.5

COIL: 0.918

CONS_SCORE: 0.3932

DSS_SCORE: 0.7161

HELIX: 0.0504

FCONS_SCORE: 0.8149

RIG_SCORE: 0.5428

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T361M	TCGA-AX-A1C9	UCEC	TCGA	DSGDSDT	DEG_SCF_TRCP1_1	0.7423
p.A350V	TCGA-AX-A2HD	UCEC	TCGA	DSGDSDT	DEG_SCF_TRCP1_1	0.1944
p.E354D	TCGA-CM-6168	COAD	TCGA	DSGDSDT	DEG_SCF_TRCP1_1	0.3056
p.S366F	TCGA-EO-A22U	UCEC	TCGA	DSGDSDT	DEG_SCF_TRCP1_1	0.1944
p.S366F	COLO-792	skin	COSMIC	DSGDSDT	DEG_SCF_TRCP1_1	0.1944
p.I348M	TCGA-MT-A67F	HNSC	TCGA	DSGDSDT	DEG_SCF_TRCP1_1	0.1389
p.D371Y	DO5863	BRCA	ICGC	DSGDSDT	DEG_SCF_TRCP1_1	0.0556
p.E369D	DO25947	LUAD	ICGC	DSGDSDT	DEG_SCF_TRCP1_1	0.1111
p.R347S	DO50097	LUSC	ICGC	DSGDSDT	DEG_SCF_TRCP1_1	0.1111
p.I360F	DO219211	LUSC	ICGC	DSGDSDT	DEG_SCF_TRCP1_1	0.7415
p.R356Q	DO222908	MELA	ICGC	DSGDSDT	DEG_SCF_TRCP1_1	0.7329
p.R347M	DO46657	PAAD	ICGC	DSGDSDT	DEG_SCF_TRCP1_1	0.1111
p.M351I	SIDM00533	Pancreatic Carcinoma	GDSC	DSGDSDT	DEG_SCF_TRCP1_1	0.2222
p.M351I	ACH-000118	Pancreatic Cancer	CCLE	DSGDSDT	DEG_SCF_TRCP1_1	0.2222
p.M351I	HuP-T3	pancreas	COSMIC	DSGDSDT	DEG_SCF_TRCP1_1	0.2222
p.A371V	SIDM01051	Ovarian Carcinoma	GDSC	DSGDSDT	DEG_SCF_TRCP1_1	0.0556
p.A371V	ACH-000936	Ovarian Cancer	CCLE	DSGDSDT	DEG_SCF_TRCP1_1	0.0556
p.A371V	EFO-27	ovary	COSMIC	DSGDSDT	DEG_SCF_TRCP1_1	0.0556
p.S362N	SIDM01387	Small Cell Lung Carcinoma	GDSC	DSGDSDT	DEG_SCF_TRCP1_1	0.3056
p.S362N	ACH-000921	Lung Cancer	CCLE	DSGDSDT	DEG_SCF_TRCP1_1	0.3056
p.K347R	KOSC-2	upper_aerodigestive_tract	COSMIC	DSGDSDT	DEG_SCF_TRCP1_1	0.1111
p.K349R	KOSC-2	upper_aerodigestive_tract	COSMIC	DSGDSDT	DEG_SCF_TRCP1_1	0.2778
p.A357S	A427	lung	COSMIC	DSGDSDT	DEG_SCF_TRCP1_1	0.7588
p.A367S	A427	lung	COSMIC	DSGDSDT	DEG_SCF_TRCP1_1	0.1667
p.A349S	A427	lung	COSMIC	DSGDSDT	DEG_SCF_TRCP1_1	0.2778
p.A365S	A427	lung	COSMIC	DSGDSDT	DEG_SCF_TRCP1_1	0.2222
p.K357R	KOSC-2	upper_aerodigestive_tract	COSMIC	DSGDSDT	DEG_SCF_TRCP1_1	0.7237
p.K363R	KOSC-2	upper_aerodigestive_tract	COSMIC	DSGDSDT	DEG_SCF_TRCP1_1	0.2778
p.S360F	COLO-792	skin	COSMIC	DSGDSDT	DEG_SCF_TRCP1_1	0.7982

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGDSDT

Degron related mutations and impact score

Drug responses associated with DLGAP1 mutations

All proteins holding degron of DSGDSDT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14490	Disks large-associated protein 1	DEG_SCF_TRCP1_1	355:361	DSGDSDT	BTRC	0.6533	More...