DegronMD

Uniprot ID: Q9UBL0

Source protein: cAMP-regulated phosphoprotein 21

Source gene: ARPP21

Class: LIG_APCC_ABBA_1

Location: 269:274

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.709

ASA_SCORE: 105.6333

COIL: 0.8072

CONS_SCORE: 0.4529

DSS_SCORE: 0.6753

HELIX: 0.1718

FCONS_SCORE: 0.7944

RIG_SCORE: 0.681

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E262Q	TCGA-17-Z031	LUAD	TCGA	MHPFRD	LIG_APCC_ABBA_1	0.1389
p.S266L	TCGA-55-8508	LUAD	TCGA	MHPFRD	LIG_APCC_ABBA_1	0.25
p.S266L	DO45341	LUAD	ICGC	MHPFRD	LIG_APCC_ABBA_1	0.25
p.S278R	TCGA-85-6560	LUSC	TCGA	MHPFRD	LIG_APCC_ABBA_1	0.6667
p.S278R	DO26752	LUSC	ICGC	MHPFRD	LIG_APCC_ABBA_1	0.6667
p.D260Y	TCGA-AC-A23H	BRCA	TCGA	MHPFRD	LIG_APCC_ABBA_1	0.0833
p.D260Y	DO2401	BRCA	ICGC	MHPFRD	LIG_APCC_ABBA_1	0.0833
p.E271G	TCGA-AX-A05S	UCEC	TCGA	MHPFRD	LIG_APCC_ABBA_1	0.7199
p.E271G	DO43218	UCEC	ICGC	MHPFRD	LIG_APCC_ABBA_1	0.7199
p.V267A	TCGA-BS-A0UV	UCEC	TCGA	MHPFRD	LIG_APCC_ABBA_1	0.2778
p.V267A	DO42793	UCEC	ICGC	MHPFRD	LIG_APCC_ABBA_1	0.2778
p.Q270R	TCGA-CG-5721	STAD	TCGA	MHPFRD	LIG_APCC_ABBA_1	0.7329
p.Q270R	DO38192	STAD	ICGC	MHPFRD	LIG_APCC_ABBA_1	0.7329
p.D260N	TCGA-EE-A3J4	SKCM	TCGA	MHPFRD	LIG_APCC_ABBA_1	0.0833
p.D260N	DO48604	SKCM	ICGC	MHPFRD	LIG_APCC_ABBA_1	0.0833
p.E282G	TCGA-EO-A3B0	UCEC	TCGA	MHPFRD	LIG_APCC_ABBA_1	0.1111
p.E282G	DO219773	UCEC	ICGC	MHPFRD	LIG_APCC_ABBA_1	0.1111
p.N277H	TCGA-F5-6814	READ	TCGA	MHPFRD	LIG_APCC_ABBA_1	0.25
p.N277H	DO36556	READ	ICGC	MHPFRD	LIG_APCC_ABBA_1	0.25
p.E276K	TCGA-RP-A695	SKCM	TCGA	MHPFRD	LIG_APCC_ABBA_1	0.2778
p.E276K	DO51270	SKCM	ICGC	MHPFRD	LIG_APCC_ABBA_1	0.2778
p.R284T	DO219098	BLCA	ICGC	MHPFRD	LIG_APCC_ABBA_1	0.0556
p.E283Q	DO49964	CESC	ICGC	MHPFRD	LIG_APCC_ABBA_1	0.0833
p.V275L	DO229006	LICA	ICGC	MHPFRD	LIG_APCC_ABBA_1	0.3056
p.R276G	DO25481	LUAD	ICGC	MHPFRD	LIG_APCC_ABBA_1	0.2778
p.Q265H	DO230524	LUSC	ICGC	MHPFRD	LIG_APCC_ABBA_1	0.2222
p.P271L	DO222595	MELA	ICGC	MHPFRD	LIG_APCC_ABBA_1	0.6471
p.R277Q	DO222653	MELA	ICGC	MHPFRD	LIG_APCC_ABBA_1	0.25
p.R277Q	DO41572	UCEC	ICGC	MHPFRD	LIG_APCC_ABBA_1	0.25
p.R277Q	SIDM01588	Endometrial Carcinoma	GDSC	MHPFRD	LIG_APCC_ABBA_1	0.25
p.R277Q	ACH-000993	Endometrial/Uterine Cancer	CCLE	MHPFRD	LIG_APCC_ABBA_1	0.25
p.D275N	DO229456	SKCA	ICGC	MHPFRD	LIG_APCC_ABBA_1	0.3056
p.D275N	DO37432	SKCM	ICGC	MHPFRD	LIG_APCC_ABBA_1	0.3056
p.H270Y	DO38039	SKCM	ICGC	MHPFRD	LIG_APCC_ABBA_1	0.6118
p.R268I	DO43041	UCEC	ICGC	MHPFRD	LIG_APCC_ABBA_1	0.3056
p.D274Y	DO52426	UCEC	ICGC	MHPFRD	LIG_APCC_ABBA_1	0.7325
p.D274Y	DO41211	UCEC	ICGC	MHPFRD	LIG_APCC_ABBA_1	0.7325
p.K279Q	DO41133	UCEC	ICGC	MHPFRD	LIG_APCC_ABBA_1	0.3056
p.S278N	DO42673	UCEC	ICGC	MHPFRD	LIG_APCC_ABBA_1	0.6667
p.L273I	SIDM01943	Colorectal Carcinoma	GDSC	MHPFRD	LIG_APCC_ABBA_1	0.7174
p.P271Q	SIDM00193	Colorectal Carcinoma	GDSC	MHPFRD	LIG_APCC_ABBA_1	0.7035
p.P271Q	ACH-000991	Colon/Colorectal Cancer	CCLE	MHPFRD	LIG_APCC_ABBA_1	0.7035
p.P271Q	SNU-81	large_intestine	COSMIC	MHPFRD	LIG_APCC_ABBA_1	0.7035
p.R273K	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	MHPFRD	LIG_APCC_ABBA_1	0.6126
p.R273K	ACH-000488	Esophageal Cancer	CCLE	MHPFRD	LIG_APCC_ABBA_1	0.6126
p.R273K	TE-11	oesophagus	COSMIC	MHPFRD	LIG_APCC_ABBA_1	0.6126
p.S280T	SIDM00217	Colorectal Carcinoma	GDSC	MHPFRD	LIG_APCC_ABBA_1	0.6111
p.S280T	ACH-000999	Colon/Colorectal Cancer	CCLE	MHPFRD	LIG_APCC_ABBA_1	0.6111
p.S280T	SNU-1040	large_intestine	COSMIC	MHPFRD	LIG_APCC_ABBA_1	0.6111
p.S278G	SIDM00363	Acute Myeloid Leukemia	GDSC	MHPFRD	LIG_APCC_ABBA_1	0.6667
p.S278G	P31-FUJ	haematopoietic_and_lymphoid_tissue	COSMIC	MHPFRD	LIG_APCC_ABBA_1	0.6667
p.N264S	ACH-001610	Brain Cancer	CCLE	MHPFRD	LIG_APCC_ABBA_1	0.1944
p.R278G	P31-FUJ	haematopoietic_and_lymphoid_tissue	COSMIC	MHPFRD	LIG_APCC_ABBA_1	0.6667
p.N280T	NCI-H2030	lung	COSMIC	MHPFRD	LIG_APCC_ABBA_1	0.6111
p.G283V	CP66-MEL	skin	COSMIC	MHPFRD	LIG_APCC_ABBA_1	0.0833
p.S284P	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	MHPFRD	LIG_APCC_ABBA_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: MHPFRD

Degron related mutations and impact score

Drug responses associated with ARPP21 mutations

All proteins holding degron of MHPFRD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UBL0	cAMP-regulated phosphoprotein 21	LIG_APCC_ABBA_1	269:274	MHPFRD	APC,CDC20,FZR1	0.709	More...