DegronMD

Uniprot ID: Q9UBL0

Source protein: cAMP-regulated phosphoprotein 21

Source gene: ARPP21

Class: DEG_SCF_FBW7_1

Location: 429:436

E3 ligase: FBXW7

DEGRON score: 0.9964

ASA_SCORE: 86.5625

COIL: 0.9469

CONS_SCORE: 0.4882

DSS_SCORE: 0.5737

HELIX: 0.0191

FCONS_SCORE: 1.0493

RIG_SCORE: 0.6632

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S426R	TCGA-A5-A2K5	UCEC	TCGA	LQSTPLVS	DEG_SCF_FBW7_1	0.25
p.S426R	DO41379	UCEC	ICGC	LQSTPLVS	DEG_SCF_FBW7_1	0.25
p.I431T	TCGA-B5-A3FC	UCEC	TCGA	LQSTPLVS	DEG_SCF_FBW7_1	0.7078
p.I431T	DO41871	UCEC	ICGC	LQSTPLVS	DEG_SCF_FBW7_1	0.7078
p.P442Q	TCGA-BQ-7048	KIRP	TCGA	LQSTPLVS	DEG_SCF_FBW7_1	0.1667
p.P442Q	TCGA-D3-A1Q6	SKCM	TCGA	LQSTPLVS	DEG_SCF_FBW7_1	0.1667
p.P442Q	DO48254	ESCA	ICGC	LQSTPLVS	DEG_SCF_FBW7_1	0.1667
p.P442Q	DO20936	KIRP	ICGC	LQSTPLVS	DEG_SCF_FBW7_1	0.1667
p.P442Q	DO37450	SKCM	ICGC	LQSTPLVS	DEG_SCF_FBW7_1	0.1667
p.S427I	TCGA-CA-6717	COAD	TCGA	LQSTPLVS	DEG_SCF_FBW7_1	0.2778
p.S427I	DO8264	COAD	ICGC	LQSTPLVS	DEG_SCF_FBW7_1	0.2778
p.S427I	DO234276	ESAD	ICGC	LQSTPLVS	DEG_SCF_FBW7_1	0.2778
p.V423A	TCGA-D3-A3ML	SKCM	TCGA	LQSTPLVS	DEG_SCF_FBW7_1	0.1667
p.V423A	DO47413	SKCM	ICGC	LQSTPLVS	DEG_SCF_FBW7_1	0.1667
p.P434S	TCGA-DU-6392	LGG	TCGA	LQSTPLVS	DEG_SCF_FBW7_1	0.6752
p.P434S	TCGA-EE-A29S	SKCM	TCGA	LQSTPLVS	DEG_SCF_FBW7_1	0.6752
p.L433F	TCGA-ER-A19M	SKCM	TCGA	LQSTPLVS	DEG_SCF_FBW7_1	0.6981
p.L433F	DO37798	SKCM	ICGC	LQSTPLVS	DEG_SCF_FBW7_1	0.6981
p.V423G	DO233791	GACA	ICGC	LQSTPLVS	DEG_SCF_FBW7_1	0.1667
p.T428S	SIDM01119	Other Solid Cancers	GDSC	LQSTPLVS	DEG_SCF_FBW7_1	0.3056
p.T428S	NCI-H727	lung	COSMIC	LQSTPLVS	DEG_SCF_FBW7_1	0.3056
p.I419L	SIDM00795	Melanoma	GDSC	LQSTPLVS	DEG_SCF_FBW7_1	0.0556
p.I419L	A375	skin	COSMIC	LQSTPLVS	DEG_SCF_FBW7_1	0.0556
p.P442S	SIDM00221	Melanoma	GDSC	LQSTPLVS	DEG_SCF_FBW7_1	0.1667
p.A444V	NCI-H2135	lung	COSMIC	LQSTPLVS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UBL0	cAMP-regulated phosphoprotein 21	DEG_SCF_FBW7_1	429:436	LQSTPLVS	FBXW7	0.9964	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons