DegronMD

Uniprot ID: Q92954

Source protein: Proteoglycan 4

Source gene: PRG4

Class: DEG_SCF_FBW7_1

Location: 706:712

E3 ligase: FBXW7

DEGRON score: 0.945

ASA_SCORE: 99.7143

COIL: 0.9696

CONS_SCORE: 0.2122

DSS_SCORE: 0.8194

HELIX: 0.011

FCONS_SCORE: 0.8767

RIG_SCORE: 0.5591

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A697V	TCGA-06-5416	GBM	TCGA	PTTPKGT	DEG_SCF_FBW7_1	0.0833
p.A697V	DO10880	GBM	ICGC	PTTPKGT	DEG_SCF_FBW7_1	0.0833
p.L717P	TCGA-24-1470	OV	TCGA	PTTPKGT	DEG_SCF_FBW7_1	0.1944
p.L717P	DO28010	OV	ICGC	PTTPKGT	DEG_SCF_FBW7_1	0.1944
p.T715A	TCGA-4R-AA8I	LIHC	TCGA	PTTPKGT	DEG_SCF_FBW7_1	0.25
p.T715A	DO49657	LIHC	ICGC	PTTPKGT	DEG_SCF_FBW7_1	0.25
p.P722H	TCGA-99-AA5R	LUAD	TCGA	PTTPKGT	DEG_SCF_FBW7_1	0.0556
p.P722H	DO51203	LUAD	ICGC	PTTPKGT	DEG_SCF_FBW7_1	0.0556
p.P720S	TCGA-AP-A1DV	UCEC	TCGA	PTTPKGT	DEG_SCF_FBW7_1	0.1111
p.P720S	DO43186	UCEC	ICGC	PTTPKGT	DEG_SCF_FBW7_1	0.1111
p.G711E	TCGA-QC-A7B5	SARC	TCGA	PTTPKGT	DEG_SCF_FBW7_1	0.6087
p.G711E	DO220239	SARC	ICGC	PTTPKGT	DEG_SCF_FBW7_1	0.6087
p.G711E	SIDM01056	Breast Carcinoma	GDSC	PTTPKGT	DEG_SCF_FBW7_1	0.6087
p.G711E	ACH-000330	Breast Cancer	CCLE	PTTPKGT	DEG_SCF_FBW7_1	0.6087
p.G711E	EFM-19	breast	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	0.6087
p.T712S	TCGA-ZB-A966	THYM	TCGA	PTTPKGT	DEG_SCF_FBW7_1	0.6005
p.A705T	DO232761	PBCA	ICGC	PTTPKGT	DEG_SCF_FBW7_1	0.3056
p.G711R	ACH-001521	Skin Cancer	CCLE	PTTPKGT	DEG_SCF_FBW7_1	0.6457
p.E719K	ACH-002287	Colon/Colorectal Cancer	CCLE	PTTPKGT	DEG_SCF_FBW7_1	0.1389
p.E719K	NCI-H630	large_intestine	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	0.1389
p.E721G	UACC-62	skin	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	0.0833
p.E721G	JURL-MK1	haematopoietic_and_lymphoid_tissue	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	0.0833
p.E721G	SK-MEL-30	skin	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	0.0833
p.P696T	HCC-15	lung	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	0.0556
p.P696T	SK-NEP-1	kidney	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	0.0556
p.P696T	COLO-824	breast	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	0.0556
p.P696T	U031	kidney	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	0.0556
p.P696T	MFE-319	endometrium	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	0.0556
p.P696T	451Lu	skin	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	0.0556
p.P722T	UACC-62	skin	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	0.0556
p.P722T	SK-MEL-30	skin	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	0.0556
p.P722T	JURL-MK1	haematopoietic_and_lymphoid_tissue	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	0.0556
p.T721S	AsPC-1	pancreas	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	0.0833
p.E721K	MCC13	skin	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	0.0833
p.T718I	NCI-H1693	lung	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTTPKGT

Degron related mutations and impact score

Drug responses associated with PRG4 mutations

All proteins holding degron of PTTPKGT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92954	Proteoglycan 4	DEG_SCF_FBW7_1	706:712	PTTPKGT	FBXW7	0.945	More...
Q92954	Proteoglycan 4	DEG_SCF_FBW7_1	751:757	PTTPKGT	FBXW7	0.9983	More...
Q92954	Proteoglycan 4	DEG_SCF_FBW7_1	775:781	PTTPKGT	FBXW7	0.9556	More...