DegronMD

Uniprot ID: Q92954

Source protein: Proteoglycan 4

Source gene: PRG4

Class: DEG_SCF_FBW7_1

Location: 751:757

E3 ligase: FBXW7

DEGRON score: 0.9983

ASA_SCORE: 99.8286

COIL: 0.9697

CONS_SCORE: 0.3701

DSS_SCORE: 0.8052

HELIX: 0.0101

FCONS_SCORE: 1.1765

RIG_SCORE: 0.5231

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P765T	TCGA-60-2714	LUSC	TCGA	PTTPKGT	DEG_SCF_FBW7_1	0.1111
p.P765T	TCGA-A2-A0CR	BRCA	TCGA	PTTPKGT	DEG_SCF_FBW7_1	0.1111
p.P765T	DO44163	BRCA	ICGC	PTTPKGT	DEG_SCF_FBW7_1	0.1111
p.P765T	DO231003	LUSC	ICGC	PTTPKGT	DEG_SCF_FBW7_1	0.1111
p.P765T	DO26530	LUSC	ICGC	PTTPKGT	DEG_SCF_FBW7_1	0.1111
p.P765T	SIDM00107	Melanoma	GDSC	PTTPKGT	DEG_SCF_FBW7_1	0.1111
p.P765T	SIDM00392	Melanoma	GDSC	PTTPKGT	DEG_SCF_FBW7_1	0.1111
p.P765T	SIDM01015	Chronic Myelogenous Leukemia	GDSC	PTTPKGT	DEG_SCF_FBW7_1	0.1111
p.P765T	SIDM01318	Hepatocellular Carcinoma	GDSC	PTTPKGT	DEG_SCF_FBW7_1	0.1111
p.P765T	ACH-000810	Skin Cancer	CCLE	PTTPKGT	DEG_SCF_FBW7_1	0.1111
p.P765T	ACH-001318	Liver Cancer	CCLE	PTTPKGT	DEG_SCF_FBW7_1	0.1111
p.P765T	UACC-62	skin	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	0.1111
p.P765T	SK-MEL-30	skin	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	0.1111
p.P765T	JURL-MK1	haematopoietic_and_lymphoid_tissue	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	0.1111
p.E764G	TCGA-A2-A0CR	BRCA	TCGA	PTTPKGT	DEG_SCF_FBW7_1	0.1389
p.E764G	TCGA-AB-2849	LAML	TCGA	PTTPKGT	DEG_SCF_FBW7_1	0.1389
p.E764G	DO44163	BRCA	ICGC	PTTPKGT	DEG_SCF_FBW7_1	0.1389
p.E764G	DO21403	LAML	ICGC	PTTPKGT	DEG_SCF_FBW7_1	0.1389
p.E764G	DO231003	LUSC	ICGC	PTTPKGT	DEG_SCF_FBW7_1	0.1389
p.E764G	ACH-000810	Skin Cancer	CCLE	PTTPKGT	DEG_SCF_FBW7_1	0.1389
p.E764G	ACH-001318	Liver Cancer	CCLE	PTTPKGT	DEG_SCF_FBW7_1	0.1389
p.E764G	JURL-MK1	haematopoietic_and_lymphoid_tissue	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	0.1389
p.E764G	SK-MEL-30	skin	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	0.1389
p.E764G	UACC-62	skin	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	0.1389
p.T752I	TCGA-CG-5733	STAD	TCGA	PTTPKGT	DEG_SCF_FBW7_1	0.7078
p.T752I	DO38551	STAD	ICGC	PTTPKGT	DEG_SCF_FBW7_1	0.7078
p.P754R	TCGA-CR-7386	HNSC	TCGA	PTTPKGT	DEG_SCF_FBW7_1	0.7512
p.P754R	DO14348	HNSC	ICGC	PTTPKGT	DEG_SCF_FBW7_1	0.7512
p.G756R	TCGA-YD-A9TA	SKCM	TCGA	PTTPKGT	DEG_SCF_FBW7_1	0.6457
p.G756R	DO229462	SKCA	ICGC	PTTPKGT	DEG_SCF_FBW7_1	0.6457
p.G756R	DO219503	SKCM	ICGC	PTTPKGT	DEG_SCF_FBW7_1	0.6457
p.C746S	DO229010	COCA	ICGC	PTTPKGT	DEG_SCF_FBW7_1	0.1944
p.C746S	DO229013	COCA	ICGC	PTTPKGT	DEG_SCF_FBW7_1	0.1944
p.C746S	DO229016	COCA	ICGC	PTTPKGT	DEG_SCF_FBW7_1	0.1944
p.C746S	DO229003	COCA	ICGC	PTTPKGT	DEG_SCF_FBW7_1	0.1944
p.C746S	DO229005	COCA	ICGC	PTTPKGT	DEG_SCF_FBW7_1	0.1944
p.T757P	DO228915	LICA	ICGC	PTTPKGT	DEG_SCF_FBW7_1	0.8142
p.G756E	DO228915	LICA	ICGC	PTTPKGT	DEG_SCF_FBW7_1	0.6087
p.G756E	DO229051	LICA	ICGC	PTTPKGT	DEG_SCF_FBW7_1	0.6087
p.P767T	SIDM00119	Non-Small Cell Lung Carcinoma	GDSC	PTTPKGT	DEG_SCF_FBW7_1	0.0556
p.P767T	SIDM00133	Non-Small Cell Lung Carcinoma	GDSC	PTTPKGT	DEG_SCF_FBW7_1	0.0556
p.P767T	ACH-000706	Lung Cancer	CCLE	PTTPKGT	DEG_SCF_FBW7_1	0.0556
p.P767T	EKVX	lung	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	0.0556
p.A750T	SIDM00392	Melanoma	GDSC	PTTPKGT	DEG_SCF_FBW7_1	0.3056
p.A750T	SIDM00025	Head and Neck Carcinoma	GDSC	PTTPKGT	DEG_SCF_FBW7_1	0.3056
p.A750T	SIDM00789	Colorectal Carcinoma	GDSC	PTTPKGT	DEG_SCF_FBW7_1	0.3056
p.A750T	SIDM01168	Colorectal Carcinoma	GDSC	PTTPKGT	DEG_SCF_FBW7_1	0.3056
p.A750T	SIDM00966	Ovarian Carcinoma	GDSC	PTTPKGT	DEG_SCF_FBW7_1	0.3056
p.A750T	SIDM00112	Kidney Carcinoma	GDSC	PTTPKGT	DEG_SCF_FBW7_1	0.3056
p.A750T	SIDM00918	Ovarian Carcinoma	GDSC	PTTPKGT	DEG_SCF_FBW7_1	0.3056
p.E764K	SIDM00007	Other Solid Cancers	GDSC	PTTPKGT	DEG_SCF_FBW7_1	0.1389
p.E764K	ACH-001550	Skin Cancer	CCLE	PTTPKGT	DEG_SCF_FBW7_1	0.1389
p.E764K	MCC13	skin	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	0.1389
p.E747K	Sarc9371	bone	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTTPKGT

Degron related mutations and impact score

Drug responses associated with PRG4 mutations

All proteins holding degron of PTTPKGT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92954	Proteoglycan 4	DEG_SCF_FBW7_1	706:712	PTTPKGT	FBXW7	0.945	More...
Q92954	Proteoglycan 4	DEG_SCF_FBW7_1	751:757	PTTPKGT	FBXW7	0.9983	More...
Q92954	Proteoglycan 4	DEG_SCF_FBW7_1	775:781	PTTPKGT	FBXW7	0.9556	More...