DegronMD

Uniprot ID: Q92954

Source protein: Proteoglycan 4

Source gene: PRG4

Class: DEG_SCF_FBW7_1

Location: 775:781

E3 ligase: FBXW7

DEGRON score: 0.9556

ASA_SCORE: 97.2143

COIL: 0.9631

CONS_SCORE: 0.3486

DSS_SCORE: 0.8255

HELIX: 0.0133

FCONS_SCORE: 1.0515

RIG_SCORE: 0.5449

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P778L	TCGA-05-4427	LUAD	TCGA	PTTPKGT	DEG_SCF_FBW7_1	0.7582
p.P778L	DO23666	LUAD	ICGC	PTTPKGT	DEG_SCF_FBW7_1	0.7582
p.T781I	TCGA-34-8455	LUSC	TCGA	PTTPKGT	DEG_SCF_FBW7_1	0.7078
p.T781I	DO50095	LUSC	ICGC	PTTPKGT	DEG_SCF_FBW7_1	0.7078
p.P765T	TCGA-60-2714	LUSC	TCGA	PTTPKGT	DEG_SCF_FBW7_1	0.0556
p.P765T	TCGA-A2-A0CR	BRCA	TCGA	PTTPKGT	DEG_SCF_FBW7_1	0.0556
p.P765T	DO44163	BRCA	ICGC	PTTPKGT	DEG_SCF_FBW7_1	0.0556
p.P765T	DO231003	LUSC	ICGC	PTTPKGT	DEG_SCF_FBW7_1	0.0556
p.P765T	DO26530	LUSC	ICGC	PTTPKGT	DEG_SCF_FBW7_1	0.0556
p.P765T	SIDM00107	Melanoma	GDSC	PTTPKGT	DEG_SCF_FBW7_1	0.0556
p.P765T	SIDM00392	Melanoma	GDSC	PTTPKGT	DEG_SCF_FBW7_1	0.0556
p.P765T	SIDM01015	Chronic Myelogenous Leukemia	GDSC	PTTPKGT	DEG_SCF_FBW7_1	0.0556
p.P765T	SIDM01318	Hepatocellular Carcinoma	GDSC	PTTPKGT	DEG_SCF_FBW7_1	0.0556
p.P765T	ACH-000810	Skin Cancer	CCLE	PTTPKGT	DEG_SCF_FBW7_1	0.0556
p.P765T	ACH-001318	Liver Cancer	CCLE	PTTPKGT	DEG_SCF_FBW7_1	0.0556
p.P765T	UACC-62	skin	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	0.0556
p.P765T	SK-MEL-30	skin	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	0.0556
p.P765T	JURL-MK1	haematopoietic_and_lymphoid_tissue	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	0.0556
p.K771T	TCGA-EO-A3AY	UCEC	TCGA	PTTPKGT	DEG_SCF_FBW7_1	0.3333
p.K771T	DO43202	UCEC	ICGC	PTTPKGT	DEG_SCF_FBW7_1	0.3333
p.P789H	TCGA-HU-A4H8	STAD	TCGA	PTTPKGT	DEG_SCF_FBW7_1	0.1111
p.P789H	DO47869	STAD	ICGC	PTTPKGT	DEG_SCF_FBW7_1	0.1111
p.T781P	TCGA-IB-7651	PAAD	TCGA	PTTPKGT	DEG_SCF_FBW7_1	0.7031
p.T781P	DO46657	PAAD	ICGC	PTTPKGT	DEG_SCF_FBW7_1	0.7031
p.P791L	DO23198	LINC	ICGC	PTTPKGT	DEG_SCF_FBW7_1	0.0556
p.KG779KW	DO222595	MELA	ICGC	PTTPKGT	DEG_SCF_FBW7_1	0.8064
p.G780R	DO218863	SKCA	ICGC	PTTPKGT	DEG_SCF_FBW7_1	0.6457
p.E772G	SIDM01015	Chronic Myelogenous Leukemia	GDSC	PTTPKGT	DEG_SCF_FBW7_1	0.25
p.E772G	SIDM01318	Hepatocellular Carcinoma	GDSC	PTTPKGT	DEG_SCF_FBW7_1	0.25
p.E772G	SIDM01451	Pancreatic Carcinoma	GDSC	PTTPKGT	DEG_SCF_FBW7_1	0.25
p.E772G	ACH-001318	Liver Cancer	CCLE	PTTPKGT	DEG_SCF_FBW7_1	0.25
p.E772G	UACC-62	skin	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	0.25
p.E772G	JURL-MK1	haematopoietic_and_lymphoid_tissue	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	0.25
p.E772G	SK-MEL-30	skin	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	0.25
p.P767T	SIDM00119	Non-Small Cell Lung Carcinoma	GDSC	PTTPKGT	DEG_SCF_FBW7_1	0.1111
p.P767T	SIDM00133	Non-Small Cell Lung Carcinoma	GDSC	PTTPKGT	DEG_SCF_FBW7_1	0.1111
p.P767T	ACH-000706	Lung Cancer	CCLE	PTTPKGT	DEG_SCF_FBW7_1	0.1111
p.P767T	EKVX	lung	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	0.1111
p.E772K	ACH-000916	Lung Cancer	CCLE	PTTPKGT	DEG_SCF_FBW7_1	0.25
p.E772K	NCI-H1573	lung	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	0.25
p.P789R	ACH-001232	Brain Cancer	CCLE	PTTPKGT	DEG_SCF_FBW7_1	0.1111
p.E788K	ACH-002396	Bone Cancer	CCLE	PTTPKGT	DEG_SCF_FBW7_1	0.1389
p.E788K	Sarc9371	bone	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	0.1389
p.T768I	NCI-H1693	lung	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	0.1389
p.P773T	SK-MEL-30	skin	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	0.2778
p.P773T	UACC-62	skin	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	0.2778
p.P773T	JURL-MK1	haematopoietic_and_lymphoid_tissue	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	0.2778
p.T773S	AsPC-1	pancreas	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	0.2778
p.T770I	NCI-H1693	lung	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	0.1944
p.T771S	AsPC-1	pancreas	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	0.3333
p.E772D	D-283MED	central_nervous_system	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTTPKGT

Degron related mutations and impact score

Drug responses associated with PRG4 mutations

All proteins holding degron of PTTPKGT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92954	Proteoglycan 4	DEG_SCF_FBW7_1	706:712	PTTPKGT	FBXW7	0.945	More...
Q92954	Proteoglycan 4	DEG_SCF_FBW7_1	751:757	PTTPKGT	FBXW7	0.9983	More...
Q92954	Proteoglycan 4	DEG_SCF_FBW7_1	775:781	PTTPKGT	FBXW7	0.9556	More...