DegronMD

Uniprot ID: Q92954

Source protein: Proteoglycan 4

Source gene: PRG4

Class: DEG_SCF_SKP2-CKS1_1

Location: 965:972

E3 ligase: SKP2,CSK1

DEGRON score: 0.9902

ASA_SCORE: 110.275

COIL: 0.9566

CONS_SCORE: 0.3044

DSS_SCORE: 0.3849

HELIX: 0.0188

FCONS_SCORE: 1.1708

RIG_SCORE: 0.8156

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L981H	TCGA-BH-A0WA	BRCA	TCGA	TQDTTPFK	DEG_SCF_SKP2-CKS1_1	0.0833
p.L981H	DO2897	BRCA	ICGC	TQDTTPFK	DEG_SCF_SKP2-CKS1_1	0.0833
p.K972E	TCGA-EO-A3B0	UCEC	TCGA	TQDTTPFK	DEG_SCF_SKP2-CKS1_1	0.7022
p.K972E	DO219773	UCEC	ICGC	TQDTTPFK	DEG_SCF_SKP2-CKS1_1	0.7022
p.T978I	TCGA-TQ-A7RF	LGG	TCGA	TQDTTPFK	DEG_SCF_SKP2-CKS1_1	0.6111
p.T978I	DO223685	LGG	ICGC	TQDTTPFK	DEG_SCF_SKP2-CKS1_1	0.6111
p.T975A	DO8264	COAD	ICGC	TQDTTPFK	DEG_SCF_SKP2-CKS1_1	0.25
p.Q959E	DO231984	LICA	ICGC	TQDTTPFK	DEG_SCF_SKP2-CKS1_1	0.1667
p.T957S	SIDM00503	Gastric Carcinoma	GDSC	TQDTTPFK	DEG_SCF_SKP2-CKS1_1	0.1111
p.T957S	FU97	stomach	COSMIC	TQDTTPFK	DEG_SCF_SKP2-CKS1_1	0.1111
p.A975T	LS-411N	large_intestine	COSMIC	TQDTTPFK	DEG_SCF_SKP2-CKS1_1	0.25
p.A973T	LS-411N	large_intestine	COSMIC	TQDTTPFK	DEG_SCF_SKP2-CKS1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92954	Proteoglycan 4	DEG_SCF_SKP2-CKS1_1	965:972	TQDTTPFK	SKP2,CSK1	0.9902	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons