DegronMD

Uniprot ID: Q92954

Source protein: Proteoglycan 4

Source gene: PRG4

Class: DEG_SCF_FBW7_1

Location: 924:931

E3 ligase: FBXW7

DEGRON score: 0.9946

ASA_SCORE: 104.8

COIL: 0.9516

CONS_SCORE: 0.1583

DSS_SCORE: 0.7456

HELIX: 0.0154

FCONS_SCORE: 1

RIG_SCORE: 0.7034

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D917H	TCGA-83-5908	LUAD	TCGA	LRTTPETT	DEG_SCF_FBW7_1	0.1389
p.D917H	DO23572	LUAD	ICGC	LRTTPETT	DEG_SCF_FBW7_1	0.1389
p.D923E	TCGA-AX-A05Z	UCEC	TCGA	LRTTPETT	DEG_SCF_FBW7_1	0.3056
p.D923E	DO40884	UCEC	ICGC	LRTTPETT	DEG_SCF_FBW7_1	0.3056
p.R925H	TCGA-B5-A3FA	UCEC	TCGA	LRTTPETT	DEG_SCF_FBW7_1	0.7133
p.R925H	DO52402	UCEC	ICGC	LRTTPETT	DEG_SCF_FBW7_1	0.7133
p.D923Y	TCGA-BS-A0UV	UCEC	TCGA	LRTTPETT	DEG_SCF_FBW7_1	0.3056
p.D923Y	DO42793	UCEC	ICGC	LRTTPETT	DEG_SCF_FBW7_1	0.3056
p.A933V	TCGA-DF-A2KU	UCEC	TCGA	LRTTPETT	DEG_SCF_FBW7_1	0.2778
p.A933V	DO223286	UCEC	ICGC	LRTTPETT	DEG_SCF_FBW7_1	0.2778
p.E940Q	TCGA-DK-A6B6	BLCA	TCGA	LRTTPETT	DEG_SCF_FBW7_1	0.0833
p.E940Q	DO48576	BLCA	ICGC	LRTTPETT	DEG_SCF_FBW7_1	0.0833
p.K918N	TCGA-EO-A3B0	UCEC	TCGA	LRTTPETT	DEG_SCF_FBW7_1	0.2778
p.K918N	DO219773	UCEC	ICGC	LRTTPETT	DEG_SCF_FBW7_1	0.2778
p.D923N	TCGA-IB-7651	PAAD	TCGA	LRTTPETT	DEG_SCF_FBW7_1	0.3056
p.D923N	DO46657	PAAD	ICGC	LRTTPETT	DEG_SCF_FBW7_1	0.3056
p.A934V	TCGA-VQ-A8PB	STAD	TCGA	LRTTPETT	DEG_SCF_FBW7_1	0.25
p.A934V	DO51766	STAD	ICGC	LRTTPETT	DEG_SCF_FBW7_1	0.25
p.K918R	DO233267	GACA	ICGC	LRTTPETT	DEG_SCF_FBW7_1	0.2778
p.A934T	DO233882	GACA	ICGC	LRTTPETT	DEG_SCF_FBW7_1	0.25
p.A934T	NCI-H1417	lung	COSMIC	LRTTPETT	DEG_SCF_FBW7_1	0.25
p.T930A	SIDM00487	Colorectal Carcinoma	GDSC	LRTTPETT	DEG_SCF_FBW7_1	0.6028
p.T930A	ACH-000963	Colon/Colorectal Cancer	CCLE	LRTTPETT	DEG_SCF_FBW7_1	0.6028
p.T930A	CCK-81	large_intestine	COSMIC	LRTTPETT	DEG_SCF_FBW7_1	0.6028
p.K936M	SIDM00220	Ovarian Carcinoma	GDSC	LRTTPETT	DEG_SCF_FBW7_1	0.3056
p.K936M	OC-314	ovary	COSMIC	LRTTPETT	DEG_SCF_FBW7_1	0.3056
p.K936T	SIDM01588	Endometrial Carcinoma	GDSC	LRTTPETT	DEG_SCF_FBW7_1	0.3056
p.K936T	ACH-000993	Endometrial/Uterine Cancer	CCLE	LRTTPETT	DEG_SCF_FBW7_1	0.3056
p.T914S	FU97	stomach	COSMIC	LRTTPETT	DEG_SCF_FBW7_1	0.0556
p.S921C	HT-3	cervix	COSMIC	LRTTPETT	DEG_SCF_FBW7_1	0.25
p.T916S	FU97	stomach	COSMIC	LRTTPETT	DEG_SCF_FBW7_1	0.2222
p.S919C	HT-3	cervix	COSMIC	LRTTPETT	DEG_SCF_FBW7_1	0.1944
p.A923T	LS-411N	large_intestine	COSMIC	LRTTPETT	DEG_SCF_FBW7_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LRTTPETT

Degron related mutations and impact score

Drug responses associated with PRG4 mutations

All proteins holding degron of LRTTPETT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92954	Proteoglycan 4	DEG_SCF_FBW7_1	924:931	LRTTPETT	FBXW7	0.9946	More...