DegronMD

Uniprot ID: Q92954

Source protein: Proteoglycan 4

Source gene: PRG4

Class: DEG_SCF_FBW7_1

Location: 233:239

E3 ligase: FBXW7

DEGRON score: 0.9467

ASA_SCORE: 92.4714

COIL: 0.9336

CONS_SCORE: 0.4353

DSS_SCORE: 0.6515

HELIX: 0.013

FCONS_SCORE: 0.8546

RIG_SCORE: 0.6834

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G223E	TCGA-19-5956	GBM	TCGA	VTTPDTS	DEG_SCF_FBW7_1	0.0556
p.G223E	DO13863	GBM	ICGC	VTTPDTS	DEG_SCF_FBW7_1	0.0556
p.G223A	TCGA-CV-7437	HNSC	TCGA	VTTPDTS	DEG_SCF_FBW7_1	0.0556
p.G223A	DO14902	HNSC	ICGC	VTTPDTS	DEG_SCF_FBW7_1	0.0556
p.S249F	TCGA-Q1-A73O	CESC	TCGA	VTTPDTS	DEG_SCF_FBW7_1	0.0556
p.S249F	DO51612	CESC	ICGC	VTTPDTS	DEG_SCF_FBW7_1	0.0556
p.L226F	DO229025	LICA	ICGC	VTTPDTS	DEG_SCF_FBW7_1	0.1389
p.D237Y	DO229009	LICA	ICGC	VTTPDTS	DEG_SCF_FBW7_1	0.6214
p.T234I	DO51953	PRAD	ICGC	VTTPDTS	DEG_SCF_FBW7_1	0.5966
p.P236R	SIDM00761	Small Cell Lung Carcinoma	GDSC	VTTPDTS	DEG_SCF_FBW7_1	0.7512
p.P236R	ACH-000752	Lung Cancer	CCLE	VTTPDTS	DEG_SCF_FBW7_1	0.7512
p.P236R	NCI-H196	lung	COSMIC	VTTPDTS	DEG_SCF_FBW7_1	0.7512
p.P236H	SIDM00980	Gastric Carcinoma	GDSC	VTTPDTS	DEG_SCF_FBW7_1	0.7694
p.P236H	ACH-000948	Gastric Cancer	CCLE	VTTPDTS	DEG_SCF_FBW7_1	0.7694
p.P236H	23132-87	stomach	COSMIC	VTTPDTS	DEG_SCF_FBW7_1	0.7694
p.T241P	ACH-001669	Leukemia	CCLE	VTTPDTS	DEG_SCF_FBW7_1	0.2778
p.T241P	ACH-002238	Leukemia	CCLE	VTTPDTS	DEG_SCF_FBW7_1	0.2778
p.T241P	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	VTTPDTS	DEG_SCF_FBW7_1	0.2778
p.T246N	BT-474	breast	COSMIC	VTTPDTS	DEG_SCF_FBW7_1	0.1389
p.N238S	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	VTTPDTS	DEG_SCF_FBW7_1	0.7069
p.N236S	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	VTTPDTS	DEG_SCF_FBW7_1	0.7069

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92954	Proteoglycan 4	DEG_SCF_FBW7_1	233:239	VTTPDTS	FBXW7	0.9467	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons