DegronMD

Uniprot ID: Q92954

Source protein: Proteoglycan 4

Source gene: PRG4

Class: DEG_SCF_FBW7_1

Location: 857:863

E3 ligase: FBXW7

DEGRON score: 0.9383

ASA_SCORE: 93.0429

COIL: 0.9697

CONS_SCORE: 0.2407

DSS_SCORE: 0.7986

HELIX: 0.0103

FCONS_SCORE: 0.9108

RIG_SCORE: 0.5893

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P873H	TCGA-44-7670	LUAD	TCGA	VSTPTTT	DEG_SCF_FBW7_1	0.0556
p.P873H	DO23555	LUAD	ICGC	VSTPTTT	DEG_SCF_FBW7_1	0.0556
p.T861N	TCGA-49-AAR9	LUAD	TCGA	VSTPTTT	DEG_SCF_FBW7_1	0.5944
p.T861N	DO218921	LUAD	ICGC	VSTPTTT	DEG_SCF_FBW7_1	0.5944
p.E856D	TCGA-EY-A215	UCEC	TCGA	VSTPTTT	DEG_SCF_FBW7_1	0.3056
p.E856D	DO233729	GACA	ICGC	VSTPTTT	DEG_SCF_FBW7_1	0.3056
p.E856D	DO42665	UCEC	ICGC	VSTPTTT	DEG_SCF_FBW7_1	0.3056
p.S869C	HT-3	cervix	COSMIC	VSTPTTT	DEG_SCF_FBW7_1	0.1667
p.T858A	EN	endometrium	COSMIC	VSTPTTT	DEG_SCF_FBW7_1	0.7139
p.T860A	EN	endometrium	COSMIC	VSTPTTT	DEG_SCF_FBW7_1	0.7139
p.E865D	D-283MED	central_nervous_system	COSMIC	VSTPTTT	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92954	Proteoglycan 4	DEG_SCF_FBW7_1	857:863	VSTPTTT	FBXW7	0.9383	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons