DegronMD

Uniprot ID: Q92954

Source protein: Proteoglycan 4

Source gene: PRG4

Class: DEG_SCF_FBW7_2

Location: 331:336

E3 ligase: FBXW7

DEGRON score: 0.9981

ASA_SCORE: 110.2

COIL: 0.9697

CONS_SCORE: 0.4702

DSS_SCORE: 0.6767

HELIX: 0.0142

FCONS_SCORE: 1.4196

RIG_SCORE: 0.6267

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G341S	TCGA-AX-A06F	UCEC	TCGA	PTPKAE	DEG_SCF_FBW7_2	0.1944
p.G341S	DO41752	UCEC	ICGC	PTPKAE	DEG_SCF_FBW7_2	0.1944
p.L344V	TCGA-Z6-AAPN	ESCA	TCGA	PTPKAE	DEG_SCF_FBW7_2	0.1111
p.A343V	DO228123	EOPC	ICGC	PTPKAE	DEG_SCF_FBW7_2	0.1389
p.A329T	DO228496	MALY	ICGC	PTPKAE	DEG_SCF_FBW7_2	0.2778
p.E336K	SIDM00215	Colorectal Carcinoma	GDSC	PTPKAE	DEG_SCF_FBW7_2	0.7022
p.E336K	SIDM00586	Hepatocellular Carcinoma	GDSC	PTPKAE	DEG_SCF_FBW7_2	0.7022
p.E336K	SIDM00473	Oral Cavity Carcinoma	GDSC	PTPKAE	DEG_SCF_FBW7_2	0.7022
p.E336K	SIDM00463	T-Lymphoblastic Leukemia	GDSC	PTPKAE	DEG_SCF_FBW7_2	0.7022
p.E336K	SIDM00908	Non-Cancerous	GDSC	PTPKAE	DEG_SCF_FBW7_2	0.7022
p.E336K	SIDM00619	Thyroid Gland Carcinoma	GDSC	PTPKAE	DEG_SCF_FBW7_2	0.7022
p.E336K	SIDM00522	Small Cell Lung Carcinoma	GDSC	PTPKAE	DEG_SCF_FBW7_2	0.7022
p.E336K	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	PTPKAE	DEG_SCF_FBW7_2	0.7022
p.E336K	SIDM01217	Other Blood Cancers	GDSC	PTPKAE	DEG_SCF_FBW7_2	0.7022
p.E336K	SIDM01617	Endometrial Carcinoma	GDSC	PTPKAE	DEG_SCF_FBW7_2	0.7022
p.E336K	SIDM01577	Plasma Cell Myeloma	GDSC	PTPKAE	DEG_SCF_FBW7_2	0.7022
p.E336K	SIDM01574	Plasma Cell Myeloma	GDSC	PTPKAE	DEG_SCF_FBW7_2	0.7022
p.E336K	SIDM01756	Chronic Myelogenous Leukemia	GDSC	PTPKAE	DEG_SCF_FBW7_2	0.7022
p.A343T	SIDM01106	Melanoma	GDSC	PTPKAE	DEG_SCF_FBW7_2	0.1389
p.A343T	ACH-000822	Skin Cancer	CCLE	PTPKAE	DEG_SCF_FBW7_2	0.1389
p.A343T	SK-MEL-24	skin	COSMIC	PTPKAE	DEG_SCF_FBW7_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92954	Proteoglycan 4	DEG_SCF_FBW7_2	331:336	PTPKAE	FBXW7	0.9981	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons