DegronMD

Uniprot ID: P01106

Source protein: Myc proto-oncogene protein

Source gene: MYC

Class: DEG_SPOP_SBC_1

Location: 170:174

E3 ligase: SPOP

DEGRON score: 0.7889

ASA_SCORE: 64.66

COIL: 0.7248

CONS_SCORE: 0.3994

DSS_SCORE: 0.3676

HELIX: 0.178

FCONS_SCORE: 0.9699

RIG_SCORE: 0.7354

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S161L	TCGA-69-8253	LUAD	TCGA	VCSTS	DEG_SPOP_SBC_1	0.5278
p.S161L	TCGA-A6-5659	COAD	TCGA	VCSTS	DEG_SPOP_SBC_1	0.5278
p.S161L	TCGA-CV-A45V	HNSC	TCGA	VCSTS	DEG_SPOP_SBC_1	0.5278
p.S161L	TCGA-D6-6825	HNSC	TCGA	VCSTS	DEG_SPOP_SBC_1	0.5278
p.S161L	TCGA-DS-A1OB	CESC	TCGA	VCSTS	DEG_SPOP_SBC_1	0.5278
p.S161L	TCGA-EE-A182	SKCM	TCGA	VCSTS	DEG_SPOP_SBC_1	0.5278
p.S161L	TCGA-H7-8501	HNSC	TCGA	VCSTS	DEG_SPOP_SBC_1	0.5278
p.S161L	TCGA-SS-A7HO	COAD	TCGA	VCSTS	DEG_SPOP_SBC_1	0.5278
p.S161L	DO233964	BPLL	ICGC	VCSTS	DEG_SPOP_SBC_1	0.5278
p.S161L	DO6323	CESC	ICGC	VCSTS	DEG_SPOP_SBC_1	0.5278
p.S161L	DO223485	CLLE	ICGC	VCSTS	DEG_SPOP_SBC_1	0.5278
p.S161L	DO223705	COAD	ICGC	VCSTS	DEG_SPOP_SBC_1	0.5278
p.S161L	DO9860	COAD	ICGC	VCSTS	DEG_SPOP_SBC_1	0.5278
p.S161L	DO14630	HNSC	ICGC	VCSTS	DEG_SPOP_SBC_1	0.5278
p.S161L	DO14202	HNSC	ICGC	VCSTS	DEG_SPOP_SBC_1	0.5278
p.S161L	DO52059	HNSC	ICGC	VCSTS	DEG_SPOP_SBC_1	0.5278
p.S161L	DO23637	LUAD	ICGC	VCSTS	DEG_SPOP_SBC_1	0.5278
p.S161L	DO233554	PRAD	ICGC	VCSTS	DEG_SPOP_SBC_1	0.5278
p.S161L	DO37814	SKCM	ICGC	VCSTS	DEG_SPOP_SBC_1	0.5278
p.L164V	TCGA-77-7139	LUSC	TCGA	VCSTS	DEG_SPOP_SBC_1	0.1667
p.L164V	DO27636	LUSC	ICGC	VCSTS	DEG_SPOP_SBC_1	0.1667
p.L164V	DO27819	MALY	ICGC	VCSTS	DEG_SPOP_SBC_1	0.1667
p.L164V	DO27793	MALY	ICGC	VCSTS	DEG_SPOP_SBC_1	0.1667
p.L164V	DO228338	MALY	ICGC	VCSTS	DEG_SPOP_SBC_1	0.1667
p.L164V	DO228368	MALY	ICGC	VCSTS	DEG_SPOP_SBC_1	0.1667
p.L164V	DO52692	MALY	ICGC	VCSTS	DEG_SPOP_SBC_1	0.1667
p.L164V	DO228478	MALY	ICGC	VCSTS	DEG_SPOP_SBC_1	0.1667
p.L164V	DO228406	MALY	ICGC	VCSTS	DEG_SPOP_SBC_1	0.1667
p.L164V	DO228829	MALY	ICGC	VCSTS	DEG_SPOP_SBC_1	0.1667
p.L164V	SIDM00985	Burkitt's Lymphoma	GDSC	VCSTS	DEG_SPOP_SBC_1	0.1667
p.L164V	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	VCSTS	DEG_SPOP_SBC_1	0.1667
p.L164V	SIDM00981	B-Cell Non-Hodgkin's Lymphoma	GDSC	VCSTS	DEG_SPOP_SBC_1	0.1667
p.L164V	SIDM00948	Burkitt's Lymphoma	GDSC	VCSTS	DEG_SPOP_SBC_1	0.1667
p.L164V	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	VCSTS	DEG_SPOP_SBC_1	0.1667
p.L164V	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	VCSTS	DEG_SPOP_SBC_1	0.1667
p.L164V	BL-41	haematopoietic_and_lymphoid_tissue	COSMIC	VCSTS	DEG_SPOP_SBC_1	0.1667
p.L164V	DOHH-2	haematopoietic_and_lymphoid_tissue	COSMIC	VCSTS	DEG_SPOP_SBC_1	0.1667
p.A180T	TCGA-BC-A10Z	LIHC	TCGA	VCSTS	DEG_SPOP_SBC_1	0.1667
p.A180T	DO23043	LIHC	ICGC	VCSTS	DEG_SPOP_SBC_1	0.1667
p.S184C	TCGA-GS-A9TV	DLBC	TCGA	VCSTS	DEG_SPOP_SBC_1	0.0556
p.S184C	DO219914	DLBC	ICGC	VCSTS	DEG_SPOP_SBC_1	0.0556
p.R181H	DO48448	BLCA	ICGC	VCSTS	DEG_SPOP_SBC_1	0.1389
p.V160L	DO234452	BPLL	ICGC	VCSTS	DEG_SPOP_SBC_1	0.0556
p.N178K	DO230316	COCA	ICGC	VCSTS	DEG_SPOP_SBC_1	0.2222
p.Y167N	DO221117	MALY	ICGC	VCSTS	DEG_SPOP_SBC_1	0.25
p.P177R	DO48577	PRAD	ICGC	VCSTS	DEG_SPOP_SBC_1	0.25
p.G175D	DO38404	STAD	ICGC	VCSTS	DEG_SPOP_SBC_1	0.3056
p.Q168R	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VCSTS	DEG_SPOP_SBC_1	0.2778
p.Q168R	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	VCSTS	DEG_SPOP_SBC_1	0.2778
p.S182T	ACH-000287	Lymphoma	CCLE	VCSTS	DEG_SPOP_SBC_1	0.1111
p.S182T	NU-DUL-1	haematopoietic_and_lymphoid_tissue	COSMIC	VCSTS	DEG_SPOP_SBC_1	0.1111
p.L178V	ACH-000440	Lymphoma	CCLE	VCSTS	DEG_SPOP_SBC_1	0.2222
p.L178V	CA46	haematopoietic_and_lymphoid_tissue	COSMIC	VCSTS	DEG_SPOP_SBC_1	0.2222
p.A183V	ACH-000567	Lymphoma	CCLE	VCSTS	DEG_SPOP_SBC_1	0.0833
p.A183V	ST486	haematopoietic_and_lymphoid_tissue	COSMIC	VCSTS	DEG_SPOP_SBC_1	0.0833
p.S175T	ACH-000687	Lymphoma	CCLE	VCSTS	DEG_SPOP_SBC_1	0.3056
p.S174T	ACH-000706	Lung Cancer	CCLE	VCSTS	DEG_SPOP_SBC_1	0.6005
p.S174T	EKVX	lung	COSMIC	VCSTS	DEG_SPOP_SBC_1	0.6005
p.C171W	ACH-001450	Lymphoma	CCLE	VCSTS	DEG_SPOP_SBC_1	0.5889
p.Y177H	ACH-001680	Lymphoma	CCLE	VCSTS	DEG_SPOP_SBC_1	0.25
p.Y177H	U-698-M	haematopoietic_and_lymphoid_tissue	COSMIC	VCSTS	DEG_SPOP_SBC_1	0.25
p.Q179H	ACH-001680	Lymphoma	CCLE	VCSTS	DEG_SPOP_SBC_1	0.1944
p.Q179H	U-698-M	haematopoietic_and_lymphoid_tissue	COSMIC	VCSTS	DEG_SPOP_SBC_1	0.1944
p.R182S	Ramos-2G6-4C10	haematopoietic_and_lymphoid_tissue	COSMIC	VCSTS	DEG_SPOP_SBC_1	0.1111
p.L163V	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	VCSTS	DEG_SPOP_SBC_1	0.1389
p.L163V	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	VCSTS	DEG_SPOP_SBC_1	0.1389
p.L163V	DOHH-2	haematopoietic_and_lymphoid_tissue	COSMIC	VCSTS	DEG_SPOP_SBC_1	0.1389
p.L163V	BL-41	haematopoietic_and_lymphoid_tissue	COSMIC	VCSTS	DEG_SPOP_SBC_1	0.1389
p.L180M	VAL	haematopoietic_and_lymphoid_tissue	COSMIC	VCSTS	DEG_SPOP_SBC_1	0.1667
p.Q167R	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	VCSTS	DEG_SPOP_SBC_1	0.25
p.L180V	NAMALWA	haematopoietic_and_lymphoid_tissue	COSMIC	VCSTS	DEG_SPOP_SBC_1	0.1667
p.R171H	EB2	haematopoietic_and_lymphoid_tissue	COSMIC	VCSTS	DEG_SPOP_SBC_1	0.8244

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VCSTS

Degron related mutations and impact score

Drug responses associated with MYC mutations

All proteins holding degron of VCSTS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P01106	Myc proto-oncogene protein	DEG_SPOP_SBC_1	170:174	VCSTS	SPOP	0.7889	More...