DegronMD

Uniprot ID: P01106

Source protein: Myc proto-oncogene protein

Source gene: MYC

Class: DEG_APCC_DBOX_1

Location: 323:331

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7543

ASA_SCORE: 111.9333

COIL: 0.6474

CONS_SCORE: 0.4375

DSS_SCORE: 0.5142

HELIX: 0.3254

FCONS_SCORE: 0.8914

RIG_SCORE: 0.8027

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q321E	TCGA-66-2785	LUSC	TCGA	KRVKLDSVR	DEG_APCC_DBOX_1	0.2778
p.Q321E	DO26520	LUSC	ICGC	KRVKLDSVR	DEG_APCC_DBOX_1	0.2778
p.V340D	TCGA-D1-A103	UCEC	TCGA	KRVKLDSVR	DEG_APCC_DBOX_1	0.0833
p.V340D	DO42312	UCEC	ICGC	KRVKLDSVR	DEG_APCC_DBOX_1	0.0833
p.K341R	TCGA-EY-A1GK	UCEC	TCGA	KRVKLDSVR	DEG_APCC_DBOX_1	0.1667
p.K341R	DO42985	UCEC	ICGC	KRVKLDSVR	DEG_APCC_DBOX_1	0.1667
p.Q321H	TCGA-FF-8046	DLBC	TCGA	KRVKLDSVR	DEG_APCC_DBOX_1	0.2778
p.Q321H	DO222303	DLBC	ICGC	KRVKLDSVR	DEG_APCC_DBOX_1	0.2778
p.Q321H	SIDM00907	Burkitt's Lymphoma	GDSC	KRVKLDSVR	DEG_APCC_DBOX_1	0.2778
p.Q321H	ACH-000440	Lymphoma	CCLE	KRVKLDSVR	DEG_APCC_DBOX_1	0.2778
p.Q321H	CA46	haematopoietic_and_lymphoid_tissue	COSMIC	KRVKLDSVR	DEG_APCC_DBOX_1	0.2778
p.S329F	TCGA-JW-A5VL	CESC	TCGA	KRVKLDSVR	DEG_APCC_DBOX_1	0.7982
p.S329F	DO49976	CESC	ICGC	KRVKLDSVR	DEG_APCC_DBOX_1	0.7982
p.A326G	TCGA-KK-A8IK	PRAD	TCGA	KRVKLDSVR	DEG_APCC_DBOX_1	0.754
p.A326G	DO219339	PRAD	ICGC	KRVKLDSVR	DEG_APCC_DBOX_1	0.754
p.T330A	DO234300	ESAD	ICGC	KRVKLDSVR	DEG_APCC_DBOX_1	0.7139
p.P327L	DO233937	GACA	ICGC	KRVKLDSVR	DEG_APCC_DBOX_1	0.7582
p.V317F	DO229032	LICA	ICGC	KRVKLDSVR	DEG_APCC_DBOX_1	0.2778
p.C315S	DO52683	MALY	ICGC	KRVKLDSVR	DEG_APCC_DBOX_1	0.1111
p.S318A	DO52683	MALY	ICGC	KRVKLDSVR	DEG_APCC_DBOX_1	0.1944
p.A336V	SIDM01090	Colorectal Carcinoma	GDSC	KRVKLDSVR	DEG_APCC_DBOX_1	0.1944
p.A336V	ACH-000943	Colon/Colorectal Cancer	CCLE	KRVKLDSVR	DEG_APCC_DBOX_1	0.1944
p.A336V	RKO	large_intestine	COSMIC	KRVKLDSVR	DEG_APCC_DBOX_1	0.1944
p.N323S	SIDM00498	Colorectal Carcinoma	GDSC	KRVKLDSVR	DEG_APCC_DBOX_1	0.7069
p.N323S	ACH-000970	Colon/Colorectal Cancer	CCLE	KRVKLDSVR	DEG_APCC_DBOX_1	0.7069
p.N323S	SNU-C5	large_intestine	COSMIC	KRVKLDSVR	DEG_APCC_DBOX_1	0.7069
p.C315Y	SIDM00451	T-Lymphoblastic Leukemia	GDSC	KRVKLDSVR	DEG_APCC_DBOX_1	0.1111
p.C315Y	ACH-000937	Leukemia	CCLE	KRVKLDSVR	DEG_APCC_DBOX_1	0.1111
p.C315Y	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	KRVKLDSVR	DEG_APCC_DBOX_1	0.1111
p.C314Y	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	KRVKLDSVR	DEG_APCC_DBOX_1	0.0833
p.Q335R	NCCIT	testis	COSMIC	KRVKLDSVR	DEG_APCC_DBOX_1	0.2222
p.A321V	RKO	large_intestine	COSMIC	KRVKLDSVR	DEG_APCC_DBOX_1	0.2778
p.N322S	SNU-C5	large_intestine	COSMIC	KRVKLDSVR	DEG_APCC_DBOX_1	0.3056
p.Q320H	CA46	haematopoietic_and_lymphoid_tissue	COSMIC	KRVKLDSVR	DEG_APCC_DBOX_1	0.25
p.A335V	RKO	large_intestine	COSMIC	KRVKLDSVR	DEG_APCC_DBOX_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KRVKLDSVR

Degron related mutations and impact score

Drug responses associated with MYC mutations

All proteins holding degron of KRVKLDSVR

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P01106	Myc proto-oncogene protein	DEG_APCC_DBOX_1	323:331	KRVKLDSVR	APC,CDC20,FZR1	0.7543	More...