DegronMD

Uniprot ID: P04198

Source protein: N-myc proto-oncogene protein

Source gene: MYCN

Class: DEG_SCF_FBW7_2

Location: 40:47

E3 ligase: FBXW7

DEGRON score: 0.9459

ASA_SCORE: 68.625

COIL: 0.8911

CONS_SCORE: 0.6499

DSS_SCORE: 0.5407

HELIX: 0.0658

FCONS_SCORE: 0.9729

RIG_SCORE: 0.6394

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P44H	TCGA-13-0888	OV	TCGA	PDSTPPGE	DEG_SCF_FBW7_2	0.7694
p.P44H	DO30420	OV	ICGC	PDSTPPGE	DEG_SCF_FBW7_2	0.7694
p.P44L	TCGA-19-1387	GBM	TCGA	PDSTPPGE	DEG_SCF_FBW7_2	0.7582
p.P44L	TCGA-A5-A0GQ	UCEC	TCGA	PDSTPPGE	DEG_SCF_FBW7_2	0.7582
p.P44L	TCGA-AX-A064	UCEC	TCGA	PDSTPPGE	DEG_SCF_FBW7_2	0.7582
p.P44L	TCGA-B5-A1MV	UCEC	TCGA	PDSTPPGE	DEG_SCF_FBW7_2	0.7582
p.P44L	TCGA-BG-A0MQ	UCEC	TCGA	PDSTPPGE	DEG_SCF_FBW7_2	0.7582
p.P44L	TCGA-D1-A15W	UCEC	TCGA	PDSTPPGE	DEG_SCF_FBW7_2	0.7582
p.P44L	TCGA-D3-A8GB	SKCM	TCGA	PDSTPPGE	DEG_SCF_FBW7_2	0.7582
p.P44L	TCGA-DI-A1BY	UCEC	TCGA	PDSTPPGE	DEG_SCF_FBW7_2	0.7582
p.P44L	TCGA-SJ-A6ZJ	UCEC	TCGA	PDSTPPGE	DEG_SCF_FBW7_2	0.7582
p.P44L	DO11573	GBM	ICGC	PDSTPPGE	DEG_SCF_FBW7_2	0.7582
p.P44L	DO48344	NBL	ICGC	PDSTPPGE	DEG_SCF_FBW7_2	0.7582
p.P44L	DO231437	NBL	ICGC	PDSTPPGE	DEG_SCF_FBW7_2	0.7582
p.P44L	DO231540	NBL	ICGC	PDSTPPGE	DEG_SCF_FBW7_2	0.7582
p.P44L	DO48841	NBL	ICGC	PDSTPPGE	DEG_SCF_FBW7_2	0.7582
p.P44L	DO227650	PBCA	ICGC	PDSTPPGE	DEG_SCF_FBW7_2	0.7582
p.P44L	DO227915	PBCA	ICGC	PDSTPPGE	DEG_SCF_FBW7_2	0.7582
p.P44L	DO35690	PBCA	ICGC	PDSTPPGE	DEG_SCF_FBW7_2	0.7582
p.P44L	DO50280	SKCM	ICGC	PDSTPPGE	DEG_SCF_FBW7_2	0.7582
p.P44L	DO219785	UCEC	ICGC	PDSTPPGE	DEG_SCF_FBW7_2	0.7582
p.P44L	DO43402	UCEC	ICGC	PDSTPPGE	DEG_SCF_FBW7_2	0.7582
p.P44L	DO43354	UCEC	ICGC	PDSTPPGE	DEG_SCF_FBW7_2	0.7582
p.P44L	DO43073	UCEC	ICGC	PDSTPPGE	DEG_SCF_FBW7_2	0.7582
p.P44L	DO41127	UCEC	ICGC	PDSTPPGE	DEG_SCF_FBW7_2	0.7582
p.P44L	DO42857	UCEC	ICGC	PDSTPPGE	DEG_SCF_FBW7_2	0.7582
p.P44L	DO41404	UCEC	ICGC	PDSTPPGE	DEG_SCF_FBW7_2	0.7582
p.P44L	DO220979	WT	ICGC	PDSTPPGE	DEG_SCF_FBW7_2	0.7582
p.P44L	DO221104	WT	ICGC	PDSTPPGE	DEG_SCF_FBW7_2	0.7582
p.P44L	SIDM00342	T-Lymphoblastic Leukemia	GDSC	PDSTPPGE	DEG_SCF_FBW7_2	0.7582
p.P44L	ACH-000104	Leukemia	CCLE	PDSTPPGE	DEG_SCF_FBW7_2	0.7582
p.P44L	LOUCY	haematopoietic_and_lymphoid_tissue	COSMIC	PDSTPPGE	DEG_SCF_FBW7_2	0.7582
p.D34E	TCGA-AP-A1DV	UCEC	TCGA	PDSTPPGE	DEG_SCF_FBW7_2	0.1667
p.D34E	DO43186	UCEC	ICGC	PDSTPPGE	DEG_SCF_FBW7_2	0.1667
p.S42L	TCGA-D3-A51R	SKCM	TCGA	PDSTPPGE	DEG_SCF_FBW7_2	0.6556
p.S42L	DO47480	SKCM	ICGC	PDSTPPGE	DEG_SCF_FBW7_2	0.6556
p.D31N	TCGA-EE-A20C	SKCM	TCGA	PDSTPPGE	DEG_SCF_FBW7_2	0.0833
p.D31N	DO222775	MELA	ICGC	PDSTPPGE	DEG_SCF_FBW7_2	0.0833
p.D31N	DO47665	SKCM	ICGC	PDSTPPGE	DEG_SCF_FBW7_2	0.0833
p.P40T	TCGA-EE-A2MK	SKCM	TCGA	PDSTPPGE	DEG_SCF_FBW7_2	0.7031
p.P40T	DO38177	SKCM	ICGC	PDSTPPGE	DEG_SCF_FBW7_2	0.7031
p.G46R	TCGA-EE-A3JD	SKCM	TCGA	PDSTPPGE	DEG_SCF_FBW7_2	0.6457
p.G46R	DO50299	SKCM	ICGC	PDSTPPGE	DEG_SCF_FBW7_2	0.6457
p.P45L	TCGA-F1-6874	STAD	TCGA	PDSTPPGE	DEG_SCF_FBW7_2	0.6471
p.P45L	DO38201	STAD	ICGC	PDSTPPGE	DEG_SCF_FBW7_2	0.6471
p.I49M	TCGA-GC-A6I3	BLCA	TCGA	PDSTPPGE	DEG_SCF_FBW7_2	0.2778
p.I49M	DO219025	BLCA	ICGC	PDSTPPGE	DEG_SCF_FBW7_2	0.2778
p.F37L	SIDM00013	Melanoma	GDSC	PDSTPPGE	DEG_SCF_FBW7_2	0.25
p.F37L	SIDM00265	Ewing's Sarcoma	GDSC	PDSTPPGE	DEG_SCF_FBW7_2	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PDSTPPGE

Degron related mutations and impact score

Drug responses associated with MYCN mutations

All proteins holding degron of PDSTPPGE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P04198	N-myc proto-oncogene protein	DEG_SCF_FBW7_2	40:47	PDSTPPGE	FBXW7	0.9459	More...