DegronMD

Uniprot ID: Q8IZL2

Source protein: Mastermind-like protein 2

Source gene: MAML2

Class: DEG_SCF_FBW7_1

Location: 841:847

E3 ligase: FBXW7

DEGRON score: 0.8713

ASA_SCORE: 105.9571

COIL: 0.9593

CONS_SCORE: 0.5981

DSS_SCORE: 0.4654

HELIX: 0.0316

FCONS_SCORE: 0.964

RIG_SCORE: 0.7232

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L849M	TCGA-AP-A1DK	UCEC	TCGA	ILTPNSS	DEG_SCF_FBW7_1	0.2778
p.L849M	DO222842	COCA	ICGC	ILTPNSS	DEG_SCF_FBW7_1	0.2778
p.L849M	DO42033	UCEC	ICGC	ILTPNSS	DEG_SCF_FBW7_1	0.2778
p.S837L	TCGA-D1-A16J	UCEC	TCGA	ILTPNSS	DEG_SCF_FBW7_1	0.2222
p.S837L	DO43033	UCEC	ICGC	ILTPNSS	DEG_SCF_FBW7_1	0.2222
p.L848I	TCGA-IB-7651	PAAD	TCGA	ILTPNSS	DEG_SCF_FBW7_1	0.3056
p.L848I	DO46657	PAAD	ICGC	ILTPNSS	DEG_SCF_FBW7_1	0.3056
p.L848P	TCGA-VQ-A8PX	STAD	TCGA	ILTPNSS	DEG_SCF_FBW7_1	0.3056
p.L848P	DO51778	STAD	ICGC	ILTPNSS	DEG_SCF_FBW7_1	0.3056
p.P844A	DO50419	PRAD	ICGC	ILTPNSS	DEG_SCF_FBW7_1	0.7503
p.M857V	SIDM01986	Non-Small Cell Lung Carcinoma	GDSC	ILTPNSS	DEG_SCF_FBW7_1	0.0556
p.M857V	SIDM01107	Melanoma	GDSC	ILTPNSS	DEG_SCF_FBW7_1	0.0556
p.M857V	SIDM00900	Non-Cancerous	GDSC	ILTPNSS	DEG_SCF_FBW7_1	0.0556
p.M857V	SIDM00261	Ewing's Sarcoma	GDSC	ILTPNSS	DEG_SCF_FBW7_1	0.0556
p.S840P	EFM-19	breast	COSMIC	ILTPNSS	DEG_SCF_FBW7_1	0.3056
p.Q849R	D-263MG	central_nervous_system	COSMIC	ILTPNSS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZL2	Mastermind-like protein 2	DEG_SCF_FBW7_1	841:847	ILTPNSS	FBXW7	0.8713	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons