DegronMD

Uniprot ID: Q8N3X1

Source protein: Formin-binding protein 4

Source gene: FNBP4

Class: DEG_SCF_FBW7_2

Location: 514:521

E3 ligase: FBXW7

DEGRON score: 0.7783

ASA_SCORE: 93.8875

COIL: 0.7659

CONS_SCORE: 0.4545

DSS_SCORE: 0.5252

HELIX: 0.1964

FCONS_SCORE: 0.9087

RIG_SCORE: 0.7392

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E507Q	TCGA-CM-6168	COAD	TCGA	VQTTPKVE	DEG_SCF_FBW7_2	0.1389
p.E507Q	DO9602	COAD	ICGC	VQTTPKVE	DEG_SCF_FBW7_2	0.1389
p.P518S	TCGA-D3-A5GU	SKCM	TCGA	VQTTPKVE	DEG_SCF_FBW7_2	0.6752
p.P518S	DO47584	SKCM	ICGC	VQTTPKVE	DEG_SCF_FBW7_2	0.6752
p.T517I	DO27875	ORCA	ICGC	VQTTPKVE	DEG_SCF_FBW7_2	0.8189

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N3X1	Formin-binding protein 4	DEG_SCF_FBW7_2	514:521	VQTTPKVE	FBXW7	0.7783	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons