DegronMD

Uniprot ID: Q8N3X1

Source protein: Formin-binding protein 4

Source gene: FNBP4

Class: DEG_SCF_SKP2-CKS1_1

Location: 755:762

E3 ligase: SKP2,CSK1

DEGRON score: 0.624

ASA_SCORE: 87.8625

COIL: 0.866

CONS_SCORE: 0.4704

DSS_SCORE: 0.8566

HELIX: 0.0561

FCONS_SCORE: 1.105

RIG_SCORE: 0.6289

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E745K	TCGA-78-7539	LUAD	TCGA	TEEDTPLK	DEG_SCF_SKP2-CKS1_1	0.0556
p.E745K	DO26210	LUAD	ICGC	TEEDTPLK	DEG_SCF_SKP2-CKS1_1	0.0556
p.G754E	TCGA-KQ-A41Q	BLCA	TCGA	TEEDTPLK	DEG_SCF_SKP2-CKS1_1	0.3056
p.G754E	DO223591	BLCA	ICGC	TEEDTPLK	DEG_SCF_SKP2-CKS1_1	0.3056
p.S772N	SIDM01764	Non-Small Cell Lung Carcinoma	GDSC	TEEDTPLK	DEG_SCF_SKP2-CKS1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N3X1	Formin-binding protein 4	DEG_SCF_SKP2-CKS1_1	755:762	TEEDTPLK	SKP2,CSK1	0.624	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons