DegronMD

Uniprot ID: Q8N307

Source protein: Mucin-20

Source gene: MUC20

Class: DEG_SCF_FBW7_1

Location: 496:502

E3 ligase: FBXW7

DEGRON score: 0.9194

ASA_SCORE: 84.5429

COIL: 0.9489

CONS_SCORE: 0.4014

DSS_SCORE: 0.6705

HELIX: 0.0164

FCONS_SCORE: 0.7326

RIG_SCORE: 0.6796

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P501S	TCGA-19-4065	GBM	TCGA	VGTPLPT	DEG_SCF_FBW7_1	0.5641
p.P501S	DO11591	GBM	ICGC	VGTPLPT	DEG_SCF_FBW7_1	0.5641
p.P501S	SIDM00040	Gastric Carcinoma	GDSC	VGTPLPT	DEG_SCF_FBW7_1	0.5641
p.P501S	ACH-002202	Gastric Cancer	CCLE	VGTPLPT	DEG_SCF_FBW7_1	0.5641
p.P501S	TMK-1	stomach	COSMIC	VGTPLPT	DEG_SCF_FBW7_1	0.5641
p.G497E	TCGA-56-8629	LUSC	TCGA	VGTPLPT	DEG_SCF_FBW7_1	0.6087
p.G497E	DO45451	LUSC	ICGC	VGTPLPT	DEG_SCF_FBW7_1	0.6087
p.P501H	TCGA-AA-3492	COAD	TCGA	VGTPLPT	DEG_SCF_FBW7_1	0.6583
p.P501H	DO8224	COAD	ICGC	VGTPLPT	DEG_SCF_FBW7_1	0.6583
p.T495S	TCGA-DD-A3A3	LIHC	TCGA	VGTPLPT	DEG_SCF_FBW7_1	0.3056
p.T495S	DO44878	LIHC	ICGC	VGTPLPT	DEG_SCF_FBW7_1	0.3056
p.V496F	TCGA-EO-A22X	UCEC	TCGA	VGTPLPT	DEG_SCF_FBW7_1	0.7068
p.V496F	DO43907	UCEC	ICGC	VGTPLPT	DEG_SCF_FBW7_1	0.7068
p.R508I	TCGA-HE-7128	KIRP	TCGA	VGTPLPT	DEG_SCF_FBW7_1	0.1667
p.R508I	DO20796	KIRP	ICGC	VGTPLPT	DEG_SCF_FBW7_1	0.1667
p.P499S	TCGA-HU-A4H8	STAD	TCGA	VGTPLPT	DEG_SCF_FBW7_1	0.6752
p.P499S	DO47869	STAD	ICGC	VGTPLPT	DEG_SCF_FBW7_1	0.6752
p.V510L	TCGA-L5-A4OS	ESCA	TCGA	VGTPLPT	DEG_SCF_FBW7_1	0.1111
p.A512T	TCGA-NC-A5HT	LUSC	TCGA	VGTPLPT	DEG_SCF_FBW7_1	0.0556
p.A512T	DO219205	LUSC	ICGC	VGTPLPT	DEG_SCF_FBW7_1	0.0556
p.T506I	DO48393	BLCA	ICGC	VGTPLPT	DEG_SCF_FBW7_1	0.2222
p.T506I	DO222884	COCA	ICGC	VGTPLPT	DEG_SCF_FBW7_1	0.2222
p.T506I	DO229013	COCA	ICGC	VGTPLPT	DEG_SCF_FBW7_1	0.2222
p.T506I	DO229016	COCA	ICGC	VGTPLPT	DEG_SCF_FBW7_1	0.2222
p.T506I	DO229003	COCA	ICGC	VGTPLPT	DEG_SCF_FBW7_1	0.2222
p.T506I	DO229005	COCA	ICGC	VGTPLPT	DEG_SCF_FBW7_1	0.2222
p.T506I	DO52365	LUSC	ICGC	VGTPLPT	DEG_SCF_FBW7_1	0.2222
p.A505T	DO48379	BLCA	ICGC	VGTPLPT	DEG_SCF_FBW7_1	0.25
p.A505T	DO229013	COCA	ICGC	VGTPLPT	DEG_SCF_FBW7_1	0.25
p.A505T	DO229016	COCA	ICGC	VGTPLPT	DEG_SCF_FBW7_1	0.25
p.A505T	DO229003	COCA	ICGC	VGTPLPT	DEG_SCF_FBW7_1	0.25
p.A505T	DO229005	COCA	ICGC	VGTPLPT	DEG_SCF_FBW7_1	0.25
p.A505T	DO51032	LAML	ICGC	VGTPLPT	DEG_SCF_FBW7_1	0.25
p.A505T	DO23549	LIRI	ICGC	VGTPLPT	DEG_SCF_FBW7_1	0.25
p.A505T	DO52365	LUSC	ICGC	VGTPLPT	DEG_SCF_FBW7_1	0.25
p.D493H	DO229010	COCA	ICGC	VGTPLPT	DEG_SCF_FBW7_1	0.25
p.D493H	DO229013	COCA	ICGC	VGTPLPT	DEG_SCF_FBW7_1	0.25
p.D493H	DO229016	COCA	ICGC	VGTPLPT	DEG_SCF_FBW7_1	0.25
p.D493H	DO229003	COCA	ICGC	VGTPLPT	DEG_SCF_FBW7_1	0.25
p.D493H	DO229005	COCA	ICGC	VGTPLPT	DEG_SCF_FBW7_1	0.25
p.T486I	DO222875	MELA	ICGC	VGTPLPT	DEG_SCF_FBW7_1	0.0556
p.V510M	SIDM00315	Glioblastoma	GDSC	VGTPLPT	DEG_SCF_FBW7_1	0.1111
p.V510M	ACH-000570	Brain Cancer	CCLE	VGTPLPT	DEG_SCF_FBW7_1	0.1111
p.A490V	SIDM00500	Colorectal Carcinoma	GDSC	VGTPLPT	DEG_SCF_FBW7_1	0.1667
p.A490V	ACH-000959	Colon/Colorectal Cancer	CCLE	VGTPLPT	DEG_SCF_FBW7_1	0.1667
p.R495P	AMO-1	haematopoietic_and_lymphoid_tissue	COSMIC	VGTPLPT	DEG_SCF_FBW7_1	0.3056
p.R495P	KYSE-270	oesophagus	COSMIC	VGTPLPT	DEG_SCF_FBW7_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VGTPLPT

Degron related mutations and impact score

Drug responses associated with MUC20 mutations

All proteins holding degron of VGTPLPT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N307	Mucin-20	DEG_SCF_FBW7_1	496:502	VGTPLPT	FBXW7	0.9194	More...